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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetic study of indicine N-oxide in pediatric cancer patients (1982)
    Springer
    Cancer chemotherapy and pharmacology 10 (1982), S. 43-46 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pharmacokinetics of the experimental antitumor agent indicine N-oxide were investigated in a group of 23 pediatric cancer patients. Plasma elimination of indicine N-oxide was best described by a two-compartment open model. The mean plasma distribution phase half-life, plasma elimination phase half-life, and plasma clearance were 8 min, 84 min, and 62 ml/min/m2 (2.1 ml/min/kg), respectively. One patient with renal impairment had an abnormally long plasma elimination phase half-life (275 min) and reduced plasma clearance (17 ml/min/m2). Plasma elimination phase half-life values increased and plasma clearance values decreased with increasing age of the pediatric patients. Plasma elimination of indicine N-oxide was more rapid in this group of children than in adults who had previously received the drug.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00257237
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Phase II trial of indicine N-oxide in relapsed pediatric solid tumors (1991)
    Springer
    Investigational new drugs 9 (1991), S. 339-342 
    Details
    ISSN: 1573-0646
    Keywords: indicine N-oxide ; pediatric solid tumors ; osteosarcoma ; neuroblastoma ; pediatric brain tumors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract We used indicine N-oxide to treat 46 children with malignant solid tumors: 17 with osteosarcoma, 12 with neuroblastoma, 13 with a brain tumor, and 4 with other miscellaneous tumors. The efficacy and toxicity of the drug was assessed at the dose of 2000 mg/m2/day for five consecutive days. None of the 39 patients evaluable for response achieved a complete or partial response. Hepatotoxicity was experienced by 13 patients: 11 patients developed asymptomatic elevations of transaminases, 1 patient developed hyperbilirubinemia, and 1 developed ascites. Indicine N-oxide appears to be ineffective in the treatment of osteosarcoma, neuroblastoma, and pediatric brain tumors at this dose and schedule. Because higher doses are associated with an unacceptably high incidence of severe, irreversible hepatotoxicity, we do not recommend further study of this agent in pediatric solid tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00183576
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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