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  • 1
    Electronic Resource
    Electronic Resource
    GENETICS IN ACUTE LYMPHATIC LEUKEMIA IN CHILDHOOD (1968)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 155 (1968), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1968.tb55064.x
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  • 2
    Electronic Resource
    Electronic Resource
    GENETICS IN ACUTE LYMPHATIC LEUKEMIA IN CHILDHOOD (1969)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 155 (1969), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1969.tb50300.x
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  • 3
    Electronic Resource
    Electronic Resource
    Inheritance of a recombinant HL-A haplotype and genetics of the HL -1 region in man (1974)
    [s.l.] : Nature Publishing Group
    Nature 248 (1974), S. 517-519 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] HL-A types and mixed lymphocyte culture reactions of a Caucasian family (designated Hea) reported here provide further information on the relationship between genes in the HL-1 region. The transmission of a recombinant HL-A type from the propositus to her progeny confirms the existence of crossing ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/248517a0
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  • 4
    Electronic Resource
    Electronic Resource
    The overwhelming postsplenectomy sepsis problem (1980)
    Springer
    World journal of surgery 4 (1980), S. 423-427 
    Details
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé La vulnérabilité à l’infection après splénectomie ne dépend ni de l’âge, ni de la maladie originelle. Toute infection survenant après splénectomie est une urgence qui peut tuer en quelques heures: elle exige donc un traitement immédiat et adéquat. La pathogénie est encore mal précisée. Des données expérimentales suggèrent que la perte du mécanisme de filtration splénique est plus importante que le déficit immunologique, ces deux facteurs pouvant cependant coexister. Il est apparemment impossible d’assurer une protection parfaite contre les infections graves après splénectomie. Mais certaines études expérimentales indiquent qu’on peut en réduire la fréquence par les nouvelles techniques chirurgicales qui évitent la splénectomie totale, par la vaccination antipneumococcique et par l’administration préventive de pénicilline. Lorsque les fonctions de la rate seront mieux connues, il sera possible de préciser le rôle prophylactique de l’autotransplantation splénique.
    Notes: Abstract Postsplenectomy vulnerability to infection is not limited to age or disease process. Postsplenectomy infection is an emergency problem that requires immediate and accurate treatment because death is potential within a few hours of onset. Although the pathogenesis of overwhelming postsplenectomy sepsis is not completely understood, experimental evidence suggests that loss of mechanical filtration is more important than immunologic deficiences resulting from splenectomy. Certainly, a combination of both may be present. While no single measure seems to completely protect against overwhelming postsplenectomy sepsis, experimental evidence suggests that by reducing or minimizing the amount of spleen removed by newer surgical techniques, and by the addition of pneumococcal vaccine and prophylactic penicillin, the incidence of overwhelming sepsis can be reduced. Further evaluation of splenic function is necessary to assess the role of autotransplantation in the prevention of postsplenectomy sepsis (Fig. 1).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02393164
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  • 5
    Electronic Resource
    Electronic Resource
    Syringomyelia in mucopolysaccharidosis type VI (Maroteaux-Lamy syndrome): imaging findings following bone marrow transplantation (1997)
    Springer
    Pediatric radiology 27 (1997), S. 736-738 
    Details
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We present the imaging findings in a patient with mucopolysaccharidosis (MPS) type VI (Maroteaux-Lamy syndrome) who developed holocord syringomyelia. This represents the only reported case of syrinx formation in a child with MPS VI. Clinical, neurologic and spinal magnetic resonance imaging findings are presented. The patient has maintained a stable clinical and neurologic course over the period following allogeneic bone marrow transplant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002470050213
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  • 6
    Electronic Resource
    Electronic Resource
    Anthracycline cardiomyopathy (1982)
    Springer
    Pediatric cardiology 3 (1982), S. 265-272 
    Details
    ISSN: 1432-1971
    Keywords: Anthracycline ; Cardiomyopathy ; Free radical ; Anthracycline analogs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Life-threatening irreversible cardiomyopathy is a major complication of anthracycline therapy, particularly in the pediatric population. The pediatric cardiologist, in concert with the primary oncologist, should therefore play a major role in the care of patients receiving these agents and in clinical trials involving their use. Many risk factors and their relationships to drug pharmacokinetics, mechanisms of action, and toxicity have been identified. These data provide a rational basis for present-day recommendations regarding anthracycline administration and dosage scheduling. They furthermore provide potential avenues for clinical investigation aimed at improving the therapeutic index of these agents: α-tocopherol, cytochrome Q10, and other free radical scavengers may decrease the deleterious effects of free radical generation on the myocardium without apparent interference with tumoricidal effect. The cardiac glycosides may decrease cardiac toxicity by specific myocardial exclusion. Anthracycline analogs have been designed to specifically inhibit myocardial binding and/or free radical generation. Clinical trials involving these agents are difficult to interpret because of variability in front end risk factors and dosage schedules in the study population. Furthermore, the relatively low (5 to 10%) incidence of affected patients implies the need for large numbers to demonstrate a statistically significant benefit. Pediatric protocols addressing these issues are urgently needed. Guidelines for present-day management and future studies are outlined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02240463
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  • 7
    Electronic Resource
    Electronic Resource
    Phase II trial of indicine N-oxide in relapsed pediatric solid tumors (1991)
    Springer
    Investigational new drugs 9 (1991), S. 339-342 
    Details
    ISSN: 1573-0646
    Keywords: indicine N-oxide ; pediatric solid tumors ; osteosarcoma ; neuroblastoma ; pediatric brain tumors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract We used indicine N-oxide to treat 46 children with malignant solid tumors: 17 with osteosarcoma, 12 with neuroblastoma, 13 with a brain tumor, and 4 with other miscellaneous tumors. The efficacy and toxicity of the drug was assessed at the dose of 2000 mg/m2/day for five consecutive days. None of the 39 patients evaluable for response achieved a complete or partial response. Hepatotoxicity was experienced by 13 patients: 11 patients developed asymptomatic elevations of transaminases, 1 patient developed hyperbilirubinemia, and 1 developed ascites. Indicine N-oxide appears to be ineffective in the treatment of osteosarcoma, neuroblastoma, and pediatric brain tumors at this dose and schedule. Because higher doses are associated with an unacceptably high incidence of severe, irreversible hepatotoxicity, we do not recommend further study of this agent in pediatric solid tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00183576
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  • 8
    Electronic Resource
    Electronic Resource
    A phase II study of cisplatin therapy in recurrent childhood brain tumors (1989)
    Springer
    Journal of neuro-oncology 7 (1989), S. 5-11 
    Details
    ISSN: 1573-7373
    Keywords: cisplatin therapy ; childhood brain tumor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Thirty-six children with brain tumors were treated with surgery, radiation and/or adjuvant chemotherapy. After tumor recurrence, cisplatin (60 mg/m2/day IV×2) was given every three to four weeks. CT scans were used to measure drug response prior to the first, third and fifth courses. Complete and partial responses were demonstrated in nine of 31 evaluable patients. Dose limiting toxicities were renal and auditory. Seven patients developed the syndrome of inappropriate antidiuretic horm one secretion. This study confirms that cisplatin is active in a spectrum of brain tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00149372
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  • 9
    Electronic Resource
    Electronic Resource
    A phase II study of diaziquone in children with recurrent or progressive primary brain tumors: A report from the Childrens Cancer Study Group (1990)
    Springer
    Journal of neuro-oncology 9 (1990), S. 69-76 
    Details
    ISSN: 1573-7373
    Keywords: AZQ ; brain tumors ; chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Seventy-five children with recurrent, progressive or metastatic primary brain tumors were treated with aziridinylbenzoquinone (AZQ; Diaziquone) at 9 mg/m2/day by 30-minute intravenous infusion for five days every three weeks. Sixty-six patients were evaluable for response by imaging studies. There were five partial responses and one complete response for a combined response rate of 9%. A complete response lasting for 35 + months occurred in one of twelve patients with metastatic or locally recurrent ependymoma. Objective responses were also seen in patients with primitive neuroectodermal tumors (PNET) (1/8), low-grade glioma (1/6), and primary central nervous system lymphoma (1/1). Stable disease of greater than six months duration was seen in patients with ependymoma, PNET and medulloblastoma. Profound and prolonged myelosuppression was the significant toxicity observed. As administered in this study, AZQ has marginal activity and severe toxicity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00167071
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