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  • 1
    Electronic Resource
    Electronic Resource
    Alanine at position 73 of HLA-C is associated with psoriasis vulgaris in Finland (1994)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 131 (1994), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A close association was found between a specific sequence of HLA-C and psoriasis vulgaris in Finnish patients (χ2=18.4, P=1.78×10−5). This sequence codes for alanine at position 73 of the HLA-C molecule in the antigen binding cleft, and alanine may play a role in susceptibility to the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1994.tb08501.x
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  • 2
    Electronic Resource
    Electronic Resource
    Characterization of Nickel-Specific T Cell Clones (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 33 (1991), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Nickel is the major cause of metal-induced allergic dermatitis. Twelve nickel-specific T cell clones were used to investigate the cellular immune reactions occurring in nickel sensitivity. The selection between the alternative T cell receptors α and βγδ and two alternative Vβ genes (Vβ5 and Vβ8) were studied to see if nickel induces a selective pressure for clones bearing particular genes. Cell surface markers were studied by monoclonal antibodies and flow cytometry. Soluble mediators were measured by an ELISA method.The clones used T cell receptor αβ genes but did not use Vβ5 or Vβ8. They were T helper clones with a primed memory marker (CD3+CD4+CD8−CD45RO+) and carried HLA-DR. None of the clones secreted IL-1α, all of them secreted IL-2 receptor. Four clones secreted IL-lβ, six IL-4 and seven IL-6, the peaks in IL-2Rand IL-6 secretion preceding 1L-4 secretion. The clones helped immunoglobulin synthesis.The clones from late effector phase of the nickel allergic reaction favours the use of T cell receptors αβ genes. Nickel-specific clones were phenotypically indistinguishable but differed in soluble mediators produced.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1991.tb01791.x
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  • 3
    Electronic Resource
    Electronic Resource
    HLA FIVE-LOCUS HAPLOTYPES IN FINNS (1996)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 23 (1996), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The extreme polymorphism of HLA genes makes them a powerful tool for distinguishing between different genetic populations. Five-locus HLA haplotypes of Finns (from Oulu, Northern Finland) are described here in order to characterize further the migration pathways of the population to Finland after the Ice Age.From random families, 364 haplotypes were obtained. The most frequent Finnish haplotype A3,Cw4,B35,DR1,DQ1 (7.7%) is a Caucasoid ancestral haplotype and is shared with Italians of Celtic and non-Celtic origin. The haplotype A1,Cw7,B8,DR3,DQ2, which occurs in 4.7% of Finns, is the most frequent haplotype in Caucasoids. The haplotypes A3,Cw7,B7,DR2,DQ1 (3.6%) and A2,Cw7,B7,DR2,DQ1 (2.5%) are shared with several Caucasoid populations and the latter also with Jamaican blacks. A2,Cw5,B44,DR5,DQ3 (0.8%) is shared with Italians of Celtic and non-Celtic origin, A2,Cw6,B13,DR7,DQ2 (1.1%) with Caucasoids in the USA and A9,Cw4,B35,DR1,DQ1 (0.8%) with Mongoloids. The haplotypes A2,CW3,B62,DR4,DQ3 (3.0%), A2,Cw2,B27,DR8,DQ4 (1.7%), A2,Cw3,B62,DR6,DQ1 (1.4%) and A2,Cw1,B27,DR4,DQ3 (1.4%) were also found to be among the most frequent in the Finnish population.The most frequent HLA haplotypes are consistent with the postulated ancient migration of populations from southern Scandinavia and Germany to Finland, the most frequent haplotype suggesting a common Celtic origin and one less frequent haplotype suggesting an influence from the east.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1996.tb00128.x
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  • 4
    Electronic Resource
    Electronic Resource
    The frequency of QAP2.1 is increased in psoriasis vulgaris patients but no unusual linkage between QAP/DQA1 or QBP/DQB1 (1997)
    Springer
    Archives of dermatological research 289 (1997), S. 373-377 
    Details
    ISSN: 1432-069X
    Keywords: Key words Psoriasis vulgaris ; Promoter regions of DQ ; TAP genes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Psoriasis vulgaris is a chronic skin disease with a genetic and immunological background. We have previously defined the two most frequent risk haplotypes in Finns: A2,B13,Cw6,DR7,DQA1*0201 and A1,B17,Cw6,DR7,DQA1*0201. The aim of this study was to further examine whether the flanking regions, URRs of DQ (QAP and QBP) and TAP1 and TAP2 genes are involved in susceptibility to psoriasis. The frequency of QAP2.1 was increased in psoriatics as compared with controls ( P c = 3.6 × 10 –2 , RR = 5.0), and the frequency of QAP4.1 was decreased in psoriasis patients ( P c = 4.2 × 10 –2 ). The frequency of the phenotype combination Val/Ile at position 379 of TAP2 was decreased in patients ( P c = 1 × 10 –2 ). The allele and phenotype frequencies of TAP1 and TAP2 genes were not different between these groups. Haplotypes A2, B13,Cw6,DR7,DQA1*0201,QAP2.1 and A1,B17,Cw6, DR7,DQA1*0201,QAP2.1 are the two most frequent HLA marker haplotypes for psoriasis vulgaris in Finns, Cw6, DR7, DQA1*0201 and QAP2.1 being the most important single alleles for the risk of this disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050207
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  • 5
    Electronic Resource
    Electronic Resource
    HLA risk haplotype Cw6,DR7,DQA1*0201 and HLA-Cw6 with reference to the clinical picture of psoriasis vulgaris (1996)
    Springer
    Archives of dermatological research 288 (1996), S. 363-365 
    Details
    ISSN: 1432-069X
    Keywords: Key words Psoriasis vulgaris ; HLA risk haplotypes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Psoriasis vulgaris has HLA associations. We have previously defined HLA-Cw6,DR7,DQA1*0201 as the central element of the risk haplotypes for psoriasis. On the other hand, Cw6 as a single gene has the strongest association with psoriasis. The aim of this study was to determine whether the risk haplotype and Cw6 correlate with the clinical parameters of the disease. The series consisted of 64 patients and the clinical parameters were age at onset, family history of psoriasis, arthritis and the frequency of inpatient treatment. The HLA risk haplotype Cw6,DR7,DQA1*0201 had previously been found in 30% and Cw6 alone in 54% of the patients. The presence of Cw6 correlated with early age at onset (P c = 0.01). The presence of the risk haplotype correlated with a positive family history of psoriasis among the first-degree relatives (P c = 0.02) and an overall positive family history (P c = 0.04), but Cw6 had a stronger correlation with an overall positive family history (P c = 0.01). There were no positive correlations with arthritis or the number of inpatient treatment periods. Only type I psoriasis was associated with Cw6 (P c = 0.0006). In conclusion, Cw6 and the haplotype Cw6,DR7,DQA1*0201 are important in the heredity of psoriasis vulgaris, but the presence of Cw6 alone is sufficient to indicate a clinically significant risk for psoriasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050064
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  • 6
    Electronic Resource
    Electronic Resource
    Immunogenetic profile of psoriasis vulgaris: association with haplotypes A2,B13,Cw6,DR7,DQA1*0201 and A1,B17,Cw6,DR7,DQA1*0201 (1996)
    Springer
    Archives of dermatological research 288 (1996), S. 63-67 
    Details
    ISSN: 1432-069X
    Keywords: Key words Psoriasis vulgaris ; Immunogenetic profile ; Race
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Psoriasis vulgaris is a skin disease with an immunological and genetic background present in 1–3% of the population. We studied the genetic susceptibility to psoriasis vulgaris in Finns with serological HLA typing and genomic HLA class II typing of the DQ and DP loci to evaluate the risk of developing psoriasis. The haplotypes most frequently distinguishing between psoriatics and controls were those that carried Cw6 ( P 〈 10 –8 ), DQA1*0201 ( P = 9.3 × 10 –6 ) and DR7 ( P = 3.9 × 10 –5 ). The two most frequent marker haplotypes were A2,B13,Cw6,DR7,DQA1*0201 and A1,B17,Cw6,DR7,DQA1*0201, which were not found among the control subjects. A deficit of haplotype B8,DR3,DQ2 (2 out of 124 in the patients versus 15 out of 106 in the controls, P = 1.5 × 10 –4 ) was found, and this was in accordance with a slightly decreased frequency of DQA1*0501 ( P = 3.1 × 10 –2 ), which was usually linked with this haplotype. These results stimulate the search for a genetic resistance factor in psoriasis. Thus, this report sheds further light on the immunogenetic background of psoriasis in Finland. We conclude that the inheritance of psoriasis has a polygenic mode, in which the Cw6,DR7,DQA1*0201 combination seems to be important ( P = 7.5 × 10 –7 , relative risk 24.4, aetiological factor 0.29).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050024
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