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  • 1
    Electronic Resource
    Electronic Resource
    Binding of nickel to the mononuclear cells and in the serum of nickel-sensitive and healthy subjects (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 12 (1987), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Nickel antigen (63Ni) binding by serum components and uptake by mononuclear cells were studied in 16 healthy and nickel-sensitive subjects, respectively. Ftaorography of serum proteins revealed five main 63Ni-bindmg tractions with molecular weights of 60–70 kd, 50 kd, 41–42 kd, 38–39 kd, and 24 kd. Only quantitative differences were seen between individuals.Autoradiography studies of cells incubated 5 h with nickel revealed 63Ni uptake by adherent monocytes. T-cells did no bind 63Ni in this early phase. 63Ni uptake In mononuclear cells was followed during a 7-day nickel-induced blast transformation. The uptake peak was reached within 1 h and there was another peak of 63Ni hinding on Day 7 of the culture, when the nickel blast transformation was in an exponential growth phase. Cells collected at this stage were analysed in SDS-page electrophoresis followed by fluorography. This revealed two 63Ni-binding protein fractions with molecular weights of 27 kd and 11 kd, respectively, in both nickel-sensitive and healthy subjects. Nickel-binding proteins obtained in serum and cells did not reveal differences between healthy and nickel-sensitive subjects in the handling of nickel antigen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1987.tb01916.x
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  • 2
    Electronic Resource
    Electronic Resource
    Lymphocyte Transformation in Nickel Allergy: Amplification of T-lymphocyte Responses to Nickel Sulphate by Macrophages in Vitro (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 12 (1980), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The cell-mediated immunity of thirty-four nickel contact dermatitis patients was evaluated by performing lymphocyte stimulations with NiSO4 (1.25 and 6.25 μg/ml) and tuberculin (PPD), phytohaemagglutinin-P, pokeweed mitogen, and concanavalin A. Twenty-six of the patients were nonatopic and eight atopic. Forty-nine healthy subjects served us controls. Nickel sulphate stimulation was significantly increased (P〈0.005) In the allergic subjects, whereas stimulation was decreased (P=0.01). The responses to the other mitogens did not differ significantly between the control subjects and the patients. The lymphocyte transformation reaction to nickel sulphate was shown to occur in T cells and to be enhanced by the helper function of macrophages.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1980.tb00041.x
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  • 3
    Electronic Resource
    Electronic Resource
    The Specificity of a Nickel Sulphate Reaction in Vitro: a Family Study and a Study of Chromium-allergic Subjects (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 13 (1981), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In vitro PPD and nickel sulphate lymphocyte blast transformation reactions were performed in ten families with one or more allergic nickel contact dermatitis patients. The healthy family members did not have an inherited ability to react to nickel in vitro. Their nickel stimulation response was significantly lower (P 〈 0.005) than that among the allergic subjects. In the families studied, atopic members did not have higher nickel reactions than nonatopic subjects. Thus, the in vitro nickel reaction is not connected to atopy. This is further confirmed by the fact that the percentage of atopic subjects (19%) in these families is not higher than the percentage in the general population. In addition, six unrelated chromium-allergic patients were tested, and their lymphocytes did not cross-react with nickel sulphate in vitro. These results indicate that the in vitro nickel blast transformation reaction is specific to clinical nickel allergy in about 90% of nickel dermatitis patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1981.tb00130.x
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  • 4
    Electronic Resource
    Electronic Resource
    Characterization of Nickel-Specific T Cell Clones (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 33 (1991), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Nickel is the major cause of metal-induced allergic dermatitis. Twelve nickel-specific T cell clones were used to investigate the cellular immune reactions occurring in nickel sensitivity. The selection between the alternative T cell receptors α and βγδ and two alternative Vβ genes (Vβ5 and Vβ8) were studied to see if nickel induces a selective pressure for clones bearing particular genes. Cell surface markers were studied by monoclonal antibodies and flow cytometry. Soluble mediators were measured by an ELISA method.The clones used T cell receptor αβ genes but did not use Vβ5 or Vβ8. They were T helper clones with a primed memory marker (CD3+CD4+CD8−CD45RO+) and carried HLA-DR. None of the clones secreted IL-1α, all of them secreted IL-2 receptor. Four clones secreted IL-lβ, six IL-4 and seven IL-6, the peaks in IL-2Rand IL-6 secretion preceding 1L-4 secretion. The clones helped immunoglobulin synthesis.The clones from late effector phase of the nickel allergic reaction favours the use of T cell receptors αβ genes. Nickel-specific clones were phenotypically indistinguishable but differed in soluble mediators produced.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1991.tb01791.x
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  • 5
    Electronic Resource
    Electronic Resource
    HLA-G POLYMORPHISM AND ALLELIC ASSOCIATION WITH HLA-A IN A FINNISH POPULATION (1996)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 23 (1996), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The polymorphism of the HLA-G gene can be identified by PCR-RFLP analysis. This short communication describes the PCR-RFLP analysis of HLA-G polymorphisms in exons 2 and 3 and the association of different HLA-G and HLA-A alleles in 26 healthy Finnish families.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1996.tb00276.x
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  • 6
    Electronic Resource
    Electronic Resource
    Alanine at position 73 of HLA-C is associated with psoriasis vulgaris in Finland (1994)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 131 (1994), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A close association was found between a specific sequence of HLA-C and psoriasis vulgaris in Finnish patients (χ2=18.4, P=1.78×10−5). This sequence codes for alanine at position 73 of the HLA-C molecule in the antigen binding cleft, and alanine may play a role in susceptibility to the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1994.tb08501.x
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  • 7
    Electronic Resource
    Electronic Resource
    HLA FIVE-LOCUS HAPLOTYPES IN FINNS (1996)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 23 (1996), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The extreme polymorphism of HLA genes makes them a powerful tool for distinguishing between different genetic populations. Five-locus HLA haplotypes of Finns (from Oulu, Northern Finland) are described here in order to characterize further the migration pathways of the population to Finland after the Ice Age.From random families, 364 haplotypes were obtained. The most frequent Finnish haplotype A3,Cw4,B35,DR1,DQ1 (7.7%) is a Caucasoid ancestral haplotype and is shared with Italians of Celtic and non-Celtic origin. The haplotype A1,Cw7,B8,DR3,DQ2, which occurs in 4.7% of Finns, is the most frequent haplotype in Caucasoids. The haplotypes A3,Cw7,B7,DR2,DQ1 (3.6%) and A2,Cw7,B7,DR2,DQ1 (2.5%) are shared with several Caucasoid populations and the latter also with Jamaican blacks. A2,Cw5,B44,DR5,DQ3 (0.8%) is shared with Italians of Celtic and non-Celtic origin, A2,Cw6,B13,DR7,DQ2 (1.1%) with Caucasoids in the USA and A9,Cw4,B35,DR1,DQ1 (0.8%) with Mongoloids. The haplotypes A2,CW3,B62,DR4,DQ3 (3.0%), A2,Cw2,B27,DR8,DQ4 (1.7%), A2,Cw3,B62,DR6,DQ1 (1.4%) and A2,Cw1,B27,DR4,DQ3 (1.4%) were also found to be among the most frequent in the Finnish population.The most frequent HLA haplotypes are consistent with the postulated ancient migration of populations from southern Scandinavia and Germany to Finland, the most frequent haplotype suggesting a common Celtic origin and one less frequent haplotype suggesting an influence from the east.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1996.tb00128.x
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  • 8
    Electronic Resource
    Electronic Resource
    Estradiol enhances nickel-induced blast transformation (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 11 (1984), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1984.tb01004.x
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  • 9
    Electronic Resource
    Electronic Resource
    Gold sensitivity blast transformation (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 11 (1984), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A 36-year-old female patient developed eczema from wearing gold jewellery. Epicutaneous skin tests were performed with gold leaf, potassium dicyanoaurate, gold sodium thiosulphate, gold chloride, sodium chloroaurate and potassium bromoaurate. The test was positive with gold sodium thiosulphate only. Blast transformation was induced with all the gold salts except sodium chloroaurate, and the positive responses seemed 10 be dose-dependent.In vitro gold salt-induced reactions are useful in the diagnosis of allergic contact dermatitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1984.tb00962.x
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  • 10
    Electronic Resource
    Electronic Resource
    HLA risk haplotype Cw6,DR7,DQA1*0201 and HLA-Cw6 with reference to the clinical picture of psoriasis vulgaris (1996)
    Springer
    Archives of dermatological research 288 (1996), S. 363-365 
    Details
    ISSN: 1432-069X
    Keywords: Key words Psoriasis vulgaris ; HLA risk haplotypes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Psoriasis vulgaris has HLA associations. We have previously defined HLA-Cw6,DR7,DQA1*0201 as the central element of the risk haplotypes for psoriasis. On the other hand, Cw6 as a single gene has the strongest association with psoriasis. The aim of this study was to determine whether the risk haplotype and Cw6 correlate with the clinical parameters of the disease. The series consisted of 64 patients and the clinical parameters were age at onset, family history of psoriasis, arthritis and the frequency of inpatient treatment. The HLA risk haplotype Cw6,DR7,DQA1*0201 had previously been found in 30% and Cw6 alone in 54% of the patients. The presence of Cw6 correlated with early age at onset (P c = 0.01). The presence of the risk haplotype correlated with a positive family history of psoriasis among the first-degree relatives (P c = 0.02) and an overall positive family history (P c = 0.04), but Cw6 had a stronger correlation with an overall positive family history (P c = 0.01). There were no positive correlations with arthritis or the number of inpatient treatment periods. Only type I psoriasis was associated with Cw6 (P c = 0.0006). In conclusion, Cw6 and the haplotype Cw6,DR7,DQA1*0201 are important in the heredity of psoriasis vulgaris, but the presence of Cw6 alone is sufficient to indicate a clinically significant risk for psoriasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050064
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