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  • 1
    Electronic Resource
    Electronic Resource
    Increased spontaneous activity following substance P infusion into A10 dopaminergic area (1978)
    [s.l.] : Nature Publishing Group
    Nature 276 (1978), S. 616-618 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1 Effect of acute bilateral infusion into the ventral tegmental area of isotonic saline (----) or substance P (- - - - ) on whole body locomotor activity measured in photocell cages. The ordinate indicates the mean photocell counts+ s.e.m., the abscissa indicates time by 10-min periods. Arrow, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/276616a0
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  • 2
    Electronic Resource
    Electronic Resource
    5-Hydroxytryptamine and punishment (1977)
    [s.l.] : Nature Publishing Group
    Nature 268 (1977), S. 741-743 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] If a response is followed by punishment, the probability of its occurrence decreases. 5-HT antagonists1"3 and synthesis inhibition4'6 have been shown to re-instate rates of punished responding. Furthermore, behavioural release following synthesis inhibition has been shown to correlate closely with ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/268741a0
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  • 3
    Electronic Resource
    Electronic Resource
    Learning in the absence of forebrain noradrenaline (1975)
    [s.l.] : Nature Publishing Group
    Nature 258 (1975), S. 422-424 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1 Acquisition of running in alleyway. Subjects were deprived to 90% of free feeding weight, a, NPT: 6, DBT. 6-OHDA was dissolved in 0.9% NaCl containing ascorbic acid (1.0 mg ml"1). Infusion rate was 1 ul min"1 in the DBT pre-paration. Appropriate sham-operated and injected controls were ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/258422a0
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  • 4
    Electronic Resource
    Electronic Resource
    A holistic approach to the classification of behaviour (1980)
    [s.l.] : Nature Publishing Group
    Nature 287 (1980), S. 663-664 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE editors of this volume have brought together a collection of review articles relating to the effects of 'chemicals' - including hormones, nutrients before and after birth, neurotransmitters and psychotropic drugs - on behaviour. The aim is to provide the student with an introductory discussion ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/287663a0
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  • 5
    Electronic Resource
    Electronic Resource
    Some behavioural signs of morphine withdrawal blocked by conditional stimuli (1975)
    [s.l.] : Nature Publishing Group
    Nature 255 (1975), S. 416-418 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] This theory is receiving support from experimental studies on animals. In rats2 and monkeys3, it has 'been shown that conditional stimuli previously associated with the withdrawal of a drug can elicit physiological disturbances characteristic of withdrawal. In contrast, they may also serve to ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/255416a0
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  • 6
    Electronic Resource
    Electronic Resource
    Cross-modal matching in the monkey after discrete temporal lobe lesions (1975)
    [s.l.] : Nature Publishing Group
    Nature 257 (1975), S. 672-674 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We have studied the effects of discrete temporal lobe lesions on cross-modal matching ability, using the Cowey and Weiskrantz method. Our subjects included three monkeys (two Macaca mulatta and one Papio papio) with foveal prestriate (FPS) lesions, two (one M. mulatta and one P. papio) with ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/257672a0
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  • 7
    Electronic Resource
    Electronic Resource
    The effects of chlordiazepoxide on a delayed pair comparison task in pigeons (1978)
    Springer
    Psychopharmacology 59 (1978), S. 57-64 
    Details
    ISSN: 1432-2072
    Keywords: Chlordiazepoxide ; Hippocampus ; Memory ; Delayed pair comparison ; Encoding ; Pigeons
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Five pigeons were successfully taught a variation of the Konorski delayed pair comparison task, using a red and a green stimulus. The bird was required to respond to the left or right hand key, depending on whether the 2 successively presented centre key stimuli were the same (left) or different (right). The delay intervals ranged from zero to 9 s, and stable performance decrements (with increasing delay) were obtained. Chlordiazepoxide which, it has been argued, produces behavioural changes similar to those observed after hippocampal lesions was found to disrupt performance at doses greater than 4 mg/kg (i.m.). All delays (including zero) were affected. Some interpretations of this result in terms of encoding and attention are discussed, and some reference made to the possible neuropharmacological basis of this drug action.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428031
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  • 8
    Electronic Resource
    Electronic Resource
    Amylobarbitone and forgetting (1980)
    Springer
    Psychopharmacology 71 (1980), S. 189-193 
    Details
    ISSN: 1432-2072
    Keywords: Sodium amylobarbitone ; Acquisition ; Rate of forgetting ; Storage ; Retrieval ; Pigeons
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In an earlier report (Hulme et al. 1979), we argued that sodium amylobarbitone (SAB) affects the acquisition of information. That conclusion was based on the finding that SAB produces rates of forgetting that are similar to control, thereby ruling out storage (and possibly retrieval) deficiencies which would predict dissimilar rates. However, it is possible that the rate of forgetting is itself influenced by the amount of information that actually entered store in the first place, and SAB reduces this by affecting acquisition. The possibility that both acquisition and storage could therefore have been affected was explored by equating control and drug zero delay performance, which was achieved by lowering the performance of control subjects. Nonetheless, subsequent rates of forgetting remained similar, thereby strengthening the acquistion hypothesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00434410
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  • 9
    Electronic Resource
    Electronic Resource
    Ethanol affects the acquisition of information (1980)
    Springer
    Psychopharmacology 71 (1980), S. 195-200 
    Details
    ISSN: 1432-2072
    Keywords: Ethanol ; Pair comparison ; Acquisition ; Storage ; Pigeons
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two experiments were carried out on pigeons to assess the effects of acute ethanol (ETOH) administration on a delayed pair comparison procedure. ETOH disrupted performance at the two higher doses (1.0 and 2.0 g/kg, given orally). When the initial (zero delay) performance levels of treated and untreated birds were equated by (indirectly) varying the to-be-remembered stimulus' exposure duration, it was found that the impairment could, to a point, be overcome. This finding is interpreted in terms of an hypothesis which suggests that ETOH affects the acquisition but not the subsequent storage of information.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00434411
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  • 10
    Electronic Resource
    Electronic Resource
    Dissociable effects of 6-OHDA-induced lesions of neostriatum on anorexia, locomotor activity and stereotypy: The role of behavioural competition (1984)
    Springer
    Psychopharmacology 83 (1984), S. 363-366 
    Details
    ISSN: 1432-2072
    Keywords: Amphetamine ; Locomotor activity ; Stereotypy ; Anorexia ; Behavioural competition ; Neostriatum ; Dopamine ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of 6-OHDA-induced lesions of neostriatum on locomotor activity, stereotypy and anorexia induced by amphetamine (0.5 mg/kg, 1.5 mg/kg and 5.0 mg/kg IP) was examined. Lesioned rats demonstrated attenuated stereotypy and anorexia but enhanced locomotor activity to amphetamine. Biochemical analysis of dopamine and noradrenaline in specific forebrain areas demonstrated significant dopamine depletion in neostriatum. Dopamine levels in mesolimbic, frontal cortex and hypothalamic areas, and noradrenaline in frontal cortex and hypothalamic areas, were not significantly reduced. The data were interpreted in terms of a response incompatibility hypothesis. It is proposed that stereotyped responses mediated by nigrostriatal dopamine neurones are incompatible with eating. In addition, it is suggested that a second form of competition, at the neuro-anatomical level, occurs between mesolimbic and nigrostriatal systems for motor output pathways and the ultimate expression of behaviour. The role of noradrenaline in amphetamine anorexia is also discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428546
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