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  • 1
    ISSN: 1573-7284
    Keywords: Blood pressure ; Coffee ; Cross-sectional studies ; Japanese men ; Multivariate analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The study aims to examine the relationship between habitual coffee consumption and blood pressure. The subjects were 3336 male self-defense officials aged 48–56 years, who received a preretirement health examination at the Self-Defense Forces Fukuoka Hospital between October 1986 and December 1992. Average coffee intake in the past year was ascertained by a self-administered questionnaire. A significant inverse relation between habitual coffee consumption and blood pressure was found with and without adjustment for alcohol use, cigarette smoking, body mass index, glucose tolerance, and green tea intake. Green tea, another major source of caffeine intake in Japanese, was unrelated to blood pressure. The adjusted mean differences per cup of coffee consumed per day were −0.6 mmHg (95% confident interval [CI]: −0.9 to −0.3, p=0.0001) in systolic blood pressure and −0.4 mmHg (95% CI: −0.5 to −0.2, p=0.0002) in diastolic blood pressure. Habitual coffee drinkers had lower blood pressure than non-drinkers at any levels of alcohol use, cigarette smoking, obesity, and glucose intolerance. Our findings consolidate the previous observation that habitual coffee consumption was associated with lower blood pressure.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-7225
    Keywords: Colorectal adenoma ; Japan ; males ; serum lipids ; size of adenoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: In the on-going study of men retiring from the Self-Defense Forces in Japan, we previously reported that serum total cholesterol was not related to colorectal adenomas but that men with low levels of serum highdensity lipoprotein (HDL) cholesterol had an elevated adenoma risk. We examined whether the previous observation was reproducible in a different set of data accrued subsequently in the study. Serum total cholesterol, HDL-cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides were compared between 138 cases of colorectal adenomas at the depth of 60 cm or less from the anus and 909 controls with normal sigmoidoscopy in the period from October 1988 to December 1990. There was virtually no relation between adenoma risk and any of the serum lipids studied with or without adjustment for smoking, alcohol use, and body mass index. In the analysis combining the earlier and present data, however, men with large adenomas (≥10 mm, n=25) tended to have lower levels of total cholesterol and LDL-cholesterol compared with controls (n=1,612); adjusted mean differences were −0.21 mmol/l (P=0.24) and −0.26 mmol/l (P=0.13), respectively. These findings are inconclusive, but hypocholesterolemia may be associated with the growth of colorectal adenoma.
    Type of Medium: Electronic Resource
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