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  • 1
    Electronic Resource
    Electronic Resource
    Experimental colonic cancer in a dog (1981)
    Springer
    Surgery today 11 (1981), S. 214-218 
    Details
    ISSN: 1436-2813
    Keywords: experimental colonic cancer ; dog ; ENNG ; suppository ; gastric cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Experimental colonic carcinoma in a dog was induced by anal insertion of an N-ethyl-N′-nitro-N-nitrosoguanidine (ENNG) suppository (each cone containing 50 mg of ENNG) for 17 months. The dog was autopsied 20 months after the initiation insertion of the suppository. Grossly, the colonic wall from the anus to the 10-cm oral side of the colon was thickened, and there was an infiltrating tumor with shallow depressions in the rough mucosa. The lymph nodes around this portion were enlarged, and white spots were found in the liver and redness in the lungs. Histological examination of the colon revealed a variety of pathologic features, e.g., undifferentiated carcinoma, squamous cell carcinoma and malignant melanoma in the region adjacent to the anus. Well and moderately differentiated adenocarcinomas involving the proper muscle layer were found in a region oral to these tumors and were accompanied by marked invasion of the blood vessels and lymphatic permeation. There were metastases to the liver, lungs and lymph nodes which corresponded to the gross findings, and also metastases to renal glomeruli. A well differentiated adenocarcinoma and signet ring cell carcinoma were evident in the gastric mucosa. This experimental model should be useful for studies related to colonic carcinoma in humans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02468841
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Habitual coffee consumption and blood pressure: A study of self-defense officials in Japan (1998)
    Springer
    European journal of epidemiology 14 (1998), S. 669-673 
    Details
    ISSN: 1573-7284
    Keywords: Blood pressure ; Coffee ; Cross-sectional studies ; Japanese men ; Multivariate analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The study aims to examine the relationship between habitual coffee consumption and blood pressure. The subjects were 3336 male self-defense officials aged 48–56 years, who received a preretirement health examination at the Self-Defense Forces Fukuoka Hospital between October 1986 and December 1992. Average coffee intake in the past year was ascertained by a self-administered questionnaire. A significant inverse relation between habitual coffee consumption and blood pressure was found with and without adjustment for alcohol use, cigarette smoking, body mass index, glucose tolerance, and green tea intake. Green tea, another major source of caffeine intake in Japanese, was unrelated to blood pressure. The adjusted mean differences per cup of coffee consumed per day were −0.6 mmHg (95% confident interval [CI]: −0.9 to −0.3, p=0.0001) in systolic blood pressure and −0.4 mmHg (95% CI: −0.5 to −0.2, p=0.0002) in diastolic blood pressure. Habitual coffee drinkers had lower blood pressure than non-drinkers at any levels of alcohol use, cigarette smoking, obesity, and glucose intolerance. Our findings consolidate the previous observation that habitual coffee consumption was associated with lower blood pressure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007478522638
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Impaired glucose tolerance, diabetes mellitus, and gallstone disease: An extended study of male self-defense officials in Japan (1999)
    Springer
    European journal of epidemiology 15 (1999), S. 245-251 
    Details
    ISSN: 1573-7284
    Keywords: Gallstone disease ; Impaired glucose tolerance ; Japanese men ; Non-insulin-dependent diabetes mellitus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Few studies have investigated the relation between glucose tolerance status and ultrasonographically determined gallstone disease. Using a 75-g oral glucose tolerance test, we examined the association of impaired glucose tolerance (IGT) and non-insulin-dependent diabetes mellitus (NIDDM) with gallstone disease in Japanese men. Subjects were men aged 48 to 59 of the Japan Self-Defense Forces who received a preretirement health examination between October 1986 to December 1994. After exclusion of 12 men under insulin treatment in the consecutive series of 7637 men, 174 were found to have gallstones; 103 were at the state of postcholecystectomy, and 6899 had normal gallbladder. IGT and NIDDM were associated with a modestly increased risk of gallstone disease; adjusted odds ratios were 1.3 (95% confidence interval [CI]: 0.9–1.8) for IGT and 1.3 (95% CI: 0.8–2.0) for NIDDM after adjustment for hospital, rank, smoking, alcohol use, and body mass index. Adjusted odds ratio for IGT and NIDDM combined was 1.3 (95% CI: 1.0–1.7, p=0.08). When prevalent gallstones and postcholecystectomy were considered separately, NIDDM showed a significant, positive association with postcholecystectomy, but not with prevalent gallstones. The findings add to evidence that glucose intolerance is associated with a modest increase in the risk of gallstone disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007506627119
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Relation of total and beverage-specific alcohol intake to body mass index and waist-to-hip ratio: A study of self-defense officials in Japan (1997)
    Springer
    European journal of epidemiology 13 (1997), S. 893-898 
    Details
    ISSN: 1573-7284
    Keywords: Alcohol intake ; Beverage ; Body mass index ; Waist-to-hip ratio
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated the independent associations of total and beverage-specific ethanol consumption with body mass index (BMI) and waist-to-hip ratio (WHR) in middle-aged Japanese males, because of the scarcity of epidemiologic data in Japan. The subjects were 2227 male self-defense officials who received a pre-retirement health examination at the Self-Defense Forces Fukuoka, Kumamoto, and Sapporo Hospitals. Data on alcohol intake, smoking, physical activity, and past medical history were obtained from a self-reported questionnaire. Height, weight, and waist and hip girth measurements were obtained at the examination. Multiple linear regression analysis was employed. Alcohol intake was positively and strongly associated with WHR (p = 0.0001), but not associated with BMI after adjustment for lifestyle variables, including either BMI or WHR. Subjects who consumed 15 ml per day or more of shochu ethanol showed a larger WHR than never drinkers, and a dose-response relationship was found. Dose-response relationships to other beverages were not found. Dose-response relationships to other beverages were not found. These findings suggest that alcohol intake is strongly and independently associated with WHR, but not with BMI. Abdominal obesity was positively associated with shochu ethanol, but not with other types of alcohol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007416322031
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    Paper (German National Licenses)
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