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  • 1
    Electronic Resource
    Electronic Resource
    Oxford UK : Blackwell Science Ltd
    Terra nova 13 (2001), S. 0 
    ISSN: 1365-3121
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: The Etna volcano is located in an apparently anomalous position on the hinge zone of the Apennines subduction and its Na-alkaline geochemistry does not favour a magma source from the deep slab as indicated for the Aeolian K-alkaline magmatism. The steeper dip of the regional foreland monocline at the front of the Apennines in the Ionian Sea than in Sicily, implies a larger rollback of the subduction hinge in the Ionian Sea. Moreover, the lengthening of the Apennines arc needs extension parallel to the arc. Therefore, the larger southeastward subduction rollback of the Ionian lithosphere with respect to the Hyblean plateau in Sicily, should kinematically produce right-lateral transtension and a sort of vertical ‘slab window’ which might explain (i) the Plio-Pleistocene alkaline magmatism of eastern Sicily (e.g. the Etna volcano) and (ii) the late Pliocene to present right lateral transtensional tectonics and seismicity of eastern Sicily. The area of transfer of different dip and rollback occurs along the inherited Mesozoic passive continental margin between Sicily and the oceanic Ionian Sea, i.e. the Malta escarpment.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Medicine 54 (2003), S. 437-452 
    ISSN: 0066-4219
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine
    Notes: Abstract Interindividual variability in the efficacy and toxicity of drug therapy is associated with polymorphisms in genes encoding drug-metabolizing enzymes, transporters, or drug targets. Pharmacogenetics aims to identify individuals predisposed to high risk of toxicity from conventional doses of cancer chemotherapeutic agents. We review the role of genetic polymorphisms in UGT1A1 and TPMT, as well as mutations in DPD, in influencing drug disposition and toxicity. Recent studies show that pharmacogenetic determinants may also influence treatment outcomes. We discuss the clinical significance of polymorphisms in TS, MTHFR, and FCGR3A, as well as the polymorphic DNA repair genes XPD and XRCC1, in influencing reponse to chemotherapy and survival outcomes. Finally, the potential implications of transporter pharmacogenetics in influencing drug bioavailability are addressed.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Earth and Planetary Science Letters 21 (1974), S. 269-276 
    ISSN: 0012-821X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Earth and Planetary Science Letters 14 (1972), S. 242-244 
    ISSN: 0012-821X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Earth and Planetary Science Letters 22 (1974), S. 123-132 
    ISSN: 0012-821X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-2048
    Keywords: Ascomycetes ; Blue light ; Carotenoid ; Light and carotenoid induction ; Light and protoperithecia induction ; Neurospora ; Nitrogen and photoinduction ; Protoperithecium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Nitrogen, as KNO3 or NH4NO3, can inhibit the photoinduction of protoperithecia in Neurospora crassa when present in the medium at a high concentration but does not inhibit the photoinduction of carotenoids. The point at which the presence of high nitrogen levels is no longer inhibitory is 5 h after illumination.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0819
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract A systematic petrographic and chemical study of chronologically ordered lava samples collected during the 1983 Etna eruption, has shown minor fluctuating variations in crystallinity and chemistry, apparently correlated with variations in the rate of effusion. Comparison with the compositional variations observed in the lavas emitted during the 1971–1983 period, has revealed a repeated evolutional tendency suggesting a small size shallow storage system periodically refilled, as in 1983, by more primitive magma.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0819
    Keywords: Calc-alkaline volcanism ; Geochemistry ; Isotopic study ; Petrology ; Magmatic evolution ; Aegean Arc ; Nisyros volcano
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Nisyros island is a calc-alkaline volcano, built up during the last 100 ka. The first cycle of its subaerial history includes the cone-building activity with three phases, each characterized by a similar sequence: (1) effusive and explosive activity fed by basaltic andesitic and andesitic magmas; and (2) effusive andextrusive activity fed by dacitic and rhyolitic magmas. The second eruptive cycle includes the caldera-forming explosive activity with two phases, each consisting of the sequence: (1) rhyolitic phreatomagmatic eruptions triggering a central caldera collapse; and (2) extrusion of dacitic-rhyolitic domes and lava flows. The rocks of this cycle are characteized by the presence of mafic enclaves with different petrographic and chemical features which testify to mixing-mingling processes between variously evolved magmas. Jumps in the degree of evolution are present in the stratigraphic series, accompanied by changes in the porphyritic index. This index ranges from 60% to about 5% and correlates with several teochemical parameters, including a negative correlation with Sr isotope ratios (0.703384–0.705120). The latter increase from basaltic andesites to intermediate rocks, but then slightly decrease in the most evolved volcanic rocks. The petrographic, geochemical and isotopic characteristics can be largely explained by processes occurring in a convecting, crystallizing and assimilating magma chamber, where crystal sorting, retention, resorption and accumulation take place. A group of crystal-rich basaltic andesites with high Sr and compatible element contents and low incompatible elements and Sr isotope ratios probably resulted from the accumulation of plagioclase and pyroxene in an andesitic liquid. Re-entrainment of plagioclase crystals in the crystallizing magma may have been responsible for the lower 87Sr/86Sr in the most evolved rocks. The gaps in the degree of evolution with time are interpreted as due to liquid segregation from a crystal mush once critical crystallinity was reached. At that stage convection halted, and a less dense, less porphyritic, more evolved magma separated from a denser crystal-rich magma portion. The differences in incompatible element enrichment of pre-and post-caldera dacites and the chemical variation in the post-caldera dome sequence are the result of hybridization of post-caldera dome magmas with more mafic magmas, as represented by the enclave compositions. The occurrence of the quenched, more mafic magmas in the two post-caldera units suggests that renewed intrusion of mafic magma took place after each collapse event.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-0819
    Keywords: Key words Calc-alkaline volcanism ; Geochemistry ; Isotopic study ; Petrology ; Magmatic evolution ; Aegean Arc ; Nisyros volcano
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract  Nisyros island is a calc-alkaline volcano, built up during the last 100 ka. The first cycle of its subaerial history includes the cone-building activity with three phases, each characterized by a similar sequence: (1) effusive and explosive activity fed by basaltic andesitic and andesitic magmas; and (2) effusive and extrusive activity fed by dacitic and rhyolitic magmas. The second eruptive cycle includes the caldera-forming explosive activity with two phases, each consisting of the sequence: (1) rhyolitic phreatomagmatic eruptions triggering a central caldera collapse; and (2) extrusion of dacitic–rhyolitic domes and lava flows. The rocks of this cycle are characterized by the presence of mafic enclaves with different petrographic and chemical features, which testify to mixing–mingling processes between variously evolved magmas. Jumps in the degree of evolution are present in the stratigraphic series, accompanied by changes in the porphyritic index. This index ranges from 60% to about 5% and correlates with several geochemical parameters, including a negative correlation with Sr isotope ratios (0.703384–0.705120). The latter increase from basaltic andesites to intermediate rocks, but then slightly decrease in the most evolved volcanic rocks. The petrographic, geochemical and isotopic characteristics can be largely explained by processes occurring in a convecting, crystallizing and assimilating magma chamber, where crystal sorting, retention, resorption and accumulation take place. A group of crystal-rich basaltic andesites with high Sr and compatible element contents and low incompatible elements and Sr isotope ratios probably resulted from the accumulation of plagioclase and pyroxene in an andesitic liquid. Re-entrainment of plagioclase crystals in the crystallizing magma may have been responsible for the lower 87Sr/86Sr in the most evolved rocks. The gaps in the degree of evolution with time are interpreted as due to liquid segregation from a crystal mush once critical crystallinity was reached. At that stage convection halted, and a less dense, less porphyritic, more evolved magma separated from a denser crystal-rich magma portion. The differences in incompatible element enrichment of pre- and post-caldera dacites and the chemical variation in the post-caldera dome sequence are the result of hybridization of post-caldera dome magmas with more mafic magmas, as represented by the enclave compositions. The occurrence of the quenched, more mafic magmas in the two post-caldera units suggests that renewed intrusion of mafic magma took place after each collapse event.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Contributions to mineralogy and petrology 23 (1969), S. 157-172 
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract The 87Sr/86Sr ratios have been determined on the volcanic rocks of Ustica, Linosa and Pantelleria Islands. The petrology of these islands is typical of volcanic products belonging to the alkalic suite. The volcanites of Ustica and Linosa Islands are mainly represented by basic terms (alkalibasalts and hawaiites), with minor mugearitic and trachytic differentiates. In addition to alkali-basalts and hawaiites, also some alkaline and peralkaline rocks of Pantelleria have been isotopically analysed. The 87Sr/86Sr ratios are consistent with a subcrustal origin for all the volcanic products of these islands. Some differences in the 87Sr/86Sr ratios have been found and tentatively related to an inhomogeneous Rb/Sr distribution in the mantle source material. The genetic relationships of these rocks with some products of the recent Tyrrhenian volcanism are also briefly discussed.
    Type of Medium: Electronic Resource
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