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  • 1
    Electronic Resource
    Electronic Resource
    The role of mast cells in redistribution of tele-methylhistamine in the body (1991)
    Springer
    Inflammation research 33 (1991), S. 33-36 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The basis of this study was the assumption that mast cells can take up tele-methylhistamine (MeHi), as is known for other biogenic amines. The influence of extracellular MeHi on its uptake (active or passive) in isolated rat mast cells and in different rat tissues was studiedin vitro. Rat peritoneal mast cells were incubated for 15 or 30 min at 37 or 1°C with different concentrations of MeHi. Submandibular gland, skeletal muscle, lung and heart of the rat (200–500 mg of each) were chopped and incubated for 20 min at 37 or 1°C in buffer containing MeHi. Histamine (Hi) and MeHi in the cells and in the tissues were then determined by HPLC assay. Mast cells were capable of taking up MeHi in a time- and dose-dependent manner. MeHi levels increased from 5–10 ng per ml of incubated cell suspension (control) to 60–100 ng/ml after 15 min incubation. It can be assumed that the accumulation of MeHi in mast cells is due to a simple diffusion process since no significant change was noticed at 1°C. The preincubation of the cells with serotonin reduced MeHi accumulation, thus indicating MeHi competes with the same binding sites in mast cells as Hi and serotonin. Tissues showed high capacity for MeHi accumulation and MeHi surmounted endogenous Hi levels. Uptake was reduced at 1°C, yet the accumulation of MeHi was still high. The results indicate that mast cells can take up a smaller portion of free MeHi and they can have a function in its micro-regulation whereas other tissue cells have a predominant role in the removal of free MeHi from the blood.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01993120
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  • 2
    Electronic Resource
    Electronic Resource
    Histamine tele-methylhistamine ratios in rat blood as a function of time after i.v. injection of compound 48/80 or histamine (1992)
    Springer
    Inflammation research 36 (1992), S. C394 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The pharmacokinetic characteristics of histamine (Hi) and tele-methylhistamine (MeHi) were studied by following their concentrations in rat blood by HPLC after i.v. injection of Hi or compound 48/80. Both injected substances caused a significant elevation of Hi as well as MeHi levels in the blood. The elimination curves for Hi showed two phases and significant differences depending on the injected substance. Following Hi injection, blood MeHi reached a maximum within 10–30 min and returned to baseline after about 50 min. (Hi reached a maximum after 15 min.) Following injection of compound 48/80, Hi reached a maximum at 10–15 min and MeHi at 40–45 min. It can be suggested that the significance of Hi or MeHi data in the circulating blood depends on the time which elapses from the maximal Hi concentration in the blood.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01997383
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Tricyclic antidepressants change plasma histamine kinetics after its secretion induced by compound 48/80 in the rat (1998)
    Springer
    Inflammation research 47 (1998), S. 26-27 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050251
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  • 4
    Electronic Resource
    Electronic Resource
    Histamine and tele-methylhistamine in cat plasma after intravenous injection of histamine (1994)
    Springer
    Inflammation research 41 (1994), S. C129 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of increased plasma histamine (Hi) on plasma tele-methylhistamine (MeHi) levels and the kinetics of Hi and MeHi elimination from plasma were studied in the cat. Hi (40 or 50 μg/kg) was injected intravenously and then Hi and MeHi were assayed by HPLC. Hi injection was followed by a significant increase in plasma MeHi levels, being maximal at 2–4 min. In most animals, maximal MeHi levels exceeded Hi itself. The half-lives (t 1/2) of injected Hi were 0.6 and 13.3 min (mean values) in the α- and β-phases, while the corresponding values for MeHi were 1.1 and 15.4 min. Thet 1/2 of exogenous MeHi (64 μg/kg, i.v.) was in the same range. Inhibitors of histamine-N-methyltransferase diminished the elimination rate of both amines studied. Plasma MeHi can thus serve as a marker for increased plasma Hi in the cat particularly because of its noticeable and delayed elevation after the rise in Hi itself.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02007797
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  • 5
    Electronic Resource
    Electronic Resource
    Effects of tele-methylhistamine and metoprine on plasma levels of histamine and on its elimination from cat plasma (1997)
    Springer
    Inflammation research 46 (1997), S. 89-90 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050105
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  • 6
    Electronic Resource
    Electronic Resource
    Histamine tele-methylhistamine ratios in rat blood as a function of time after i.v. injection of compund 48/80 of histamine (1993)
    Springer
    Inflammation research 38 (1993), S. 296-296 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01976225
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Increased plasma tele-methylhistamine levels in the rat: Effects on plasma and tissue histamine and its elimination (1995)
    Springer
    Inflammation research 44 (1995), S. S88 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01674410
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  • 8
    Electronic Resource
    Electronic Resource
    Kinetics of injected histamine in cat plasma after antihistamine prophylaxis (2000)
    Springer
    Inflammation research 49 (2000), S. 74-75 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00000192
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    The degradation of histamine in some animal species (1986)
    Springer
    Inflammation research 18 (1986), S. 30-33 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this work was 1. determine the major [3H]-metabolites of histaminein vivo by using the musculus gracilis of the dog, andin vitro in different tissues of the cat, 2. determine the endogenous levels of histamine and Nτ-methylhistamine in some tissues of the cat and the rat. 1. [3H] histamine injection into arterial supply of the muscle of the dog: after 60 minutes the content of [3H] histamine in the muscle was 1.9\+-0.6% and the content of [3H] N\gt-methylhistamine and [3H] \lsAcid metabolites\rs was 47\+-6.7% and 51.0\+-6.5%. The cat tissuesin vitro showed the following t1/2 for exogenous histamine: submandibular gland, 95.9 min, parotid gland, 36.1 min, stomach pylorus, 39.5 min, thyroid gland, 28.3 min, liver, 23.7 min. 2. Endogenous levels of histamine and N\gt-methylhistamine were determined in the cat and the rat. In general, the contents of endogenous histamine and N\gt-methylhistamine were similar to the data obtained with labelled [3H] histamine. In both species submandibular gland was among the richest tissues in N\gt-methylhistamine content. The provenience of Nτ-methylhistamine in mast cells is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01987974
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  • 10
    Electronic Resource
    Electronic Resource
    Kinetics of histamine and tele-methylhistamine elimination from rat plasma (1993)
    Springer
    Inflammation research 38 (1993), S. C304 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Plasma levels of histamine (Hi) and tele-methylhistamine (MeHi) were measured by HPLC after intravenous bolus injection of Hi (45 μg/kg) or MeHi (55 μg/kg) in the rat. Increases in plasma Hi (from baseline 2.8±0.4 to about 50 ng/ml at 2 min after the injection) were accompanied by a significant increase in MeHi levels (baseline 1.2±0.3 ng/ml rising up to 11 ng/ml, 6 min after Hi application). After rapid intravenous injection, Hi and MeHi elimination from plasma could be fitted by a double exponential function with half lives in the α and β phases of about 20 sec and 4 min (Hi) or 1 min and 43 min (MeHi). The results suggest that measurement of plasma MeHi, as an indirect marker of Hi release, has an advantage over measuring Hi itself.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01996494
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