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A Solid-Phase Radioimmunoassay for Anti-Histone Antibodies in Human Sera: Comparison with an Immunofluorescence Assay (1982)

RUBIN, R. L. ; JOSLIN, F. G. ; TAN, E. M.

Oxford, UK : Blackwell Publishing Ltd

Scandinavian journal of immunology 15 (1982), S. 0

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ISSN: 1365-3083

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: A solid-phase assay for anti-histone antibodies is described, in which antibodies bound to calf thymus total histones, specific histone classes, or chromatin were detected by radioactive anti-human IgG, IgA or IgM. The reactivity of human sera from various rheumatic diseases was analysed by this assay and compared with results obtained from an indirect immunofluorescence assay (FANA) previously described. Sera that were positive in the FANA assay were usually positive in the solid-phase assay when total histones were the solid-phase antigen. However, many sera had IgM antibodies to total histones in the solid-phase assay but gave no detectable reaction in the FANA assay. Results from the solid-phase assay, using individual histones and chromatin, showed that the anti-histone antibodies in these sera were predominantly reactive with histones H3-H4 and did not bind well to histones complexed to DNA in the form of chromatin.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1365-3083.1982.tb00622.x

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Genetic Marker of the γA2 Subgroup of γA Immunoglobulins (1969)

KUNKEL, H. G. ; SMITH, W. K. ; JOSLIN, F. G. ; [et al.]

[s.l.] : Nature Publishing Group

Nature 223 (1969), S. 1247-1248

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ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] A genetic marker for the γA2 immunoglobulin has been delineated by precipitating and haemagglutination inhibition techniques with a human antiserum. The marker varies widely in incidence in different population groups. Although associated with all the major Gm gene complexes, a close linkage ...