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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of medicinal chemistry 18 (1975), S. 1051-1056 
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of medicinal chemistry 19 (1976), S. 1425-1426 
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    International journal of colorectal disease 12 (1997), S. 326-328 
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé. Un mésothélium papillaire bien différencié diffus constitue une néoplasie rare de la cavité péritonéale et a généralement été considéré comme étant une tumeur avec des potentialités de malignité réduite. Les mésothéliums papillaires bien différenciés publiés dans la littérature récente sont considérés comme des lésions limites ayant une évolution bénigne à long terme. Il n'y a toutefois que peu de séries ayant étudié un petit nombre de cas de mésothéliums diffus bien différenciés. La survenue d'une telle lésion de manière synchrone à une deuxième tumeur maligne est donc particulièrement rare. Une telle situation clinique suggèrerait plutôt une dissémination tumorale diffuse au péritoine secondaire à un traitement palliatif inadéquat. A notre connaissance, ce cas constitue une première description de la survenue simultanée d'un carcinome rectal et d'un mésothélium papillaire diffus bien diffèrencié du péritoine.
    Notes: Abstract. Diffuse well differentiated papillary mesothelioma is a rare neoplasms of the peritoneal cavity which has generally been regarded as a tumor with low-grade malignant potential [1 – 4]. The well differentiated papillary mesotheliomas reported in recent literature are considered as border line lesions with a long term benign clinical course. There are however, only few studies with small numbers of diffuse well differentiated mesotheliomas [1, 2, 5, 6]. The synchronous appearance of such a lesion with a second malignancy therefore is a very rare event. Such a clinical scenario would suggest diffuse tumor spread to the peritoneum resulting in an inappropriate palliative procedure alone being undertaken. To our knowledge this is the first report of the simultaneous occurrence of a rectal carcinoma in combination with a diffuse well differentiated papillary mesothelioma of the peritoneum.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Annals of biomedical engineering 27 (1999), S. 721-730 
    ISSN: 1573-9686
    Keywords: Fibroblast ; Cornea ; Biomechanics ; Collagen matrix ; Finite-element modeling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Although it is known that cells promote structural reorganization of the collagen architecture, how individual cells exert mechanical tension on the matrix is not clearly understood. In the present study we have investigated the mechanical interaction of individual corneal fibroblasts with a collagen matrix using an improved version of our previously described in vitro force-measurement system (Roy, P. et al. Exp. Cell Res. 232:106–117, 1997). The elastic distortion of the collagen matrix exerted by cells was temporally recorded and analyzed using a two-dimensional finite-element model to quantify the forces exerted on the matrix. Time-lapse videomicroscopy of serum-cultured cells on the matrix for up to 6 h revealed that individual fibroblasts generated measurable tension on the matrix during pseudopodial extension and slow retraction. Fast retraction, an event observed during active cell migration, was associated with dramatic release of tension on the matrix. An apparent inverse correlation was observed between cell translocation and maintenance of matrix tension. Additional experiments with cells under serum-free conditions revealed that these cells fail to generate any detectable tension on the matrix despite undergoing filopodial extension and retraction. Since serum-free cells do not form focal adhesions or stress fibers, these experimental data suggest that contractility of nonmotile cells, coupled with strong cell–matrix adhesion, is the most favorable mechanism of generating and maintaining tension on the extracellular matrix. © 1999 Biomedical Engineering Society. PAC99: 8718Ed, 8715La, 8714Ee, 4266Ct, 0270Dh
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1433-0563
    Keywords: Schlüsselwörter Stumpfes Bauchtrauma ; Kindliches Polytrauma ; Kindliche Nierenverletzungen ; CT ; Keywords Blunt abdominal trauma ; Pediatric polytraumatism ; Pediatric renal trauma ; CT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Renal lesions are frequently encountered in blunt pediatric abdominal trauma. In this retrospective study, we analyzed the incidence of renal trauma in these trauma patients to determine which diagnostic and therapeutic approaches were most predictive. From 1976 to 1996, 308 children sustaining blunt abdominal trauma were admitted to our department. Patients were evaluated using abdominal paracentesis, ultrasonography, and urinary analysis. In specific cases, IV urography, CT scan, and/or angiography were applied. We used the Organ Injury Scale (OIS) for classification of renal trauma into five grades. We encountered 69 serious abdominal traumas. Thirty-six patients sustained renal lesions grade 2 (G2) or higher; 20 children were polytraumatized. There were 67 renal lesions with 28 G1, 22 G2, 8 G3, 5 G4, 1G5, and 3 lesions of the urinary tract. Ultrasonography and urinary analysis were found to be optimal diagnostic means for screening and observing the course of renal lesions. For lesions G2 or higher, CT scan was the most reliable in classifying and diagnosing renal lesions. This superceded IV urography. If no contrast medium was excreted in the CT scan, angiography was indicated. Only ten patients proceeded to operative therapy. During the period reviewed, a shift from operative to conservative treatment was notable with a tendency toward minimally invasive therapy. If lesions were G4 or G5, operative treatment was always indicated.
    Notes: Zusammenfassung Die Nierenverletzungen gehören zu den häufigsten Folgen des stumpfen Bauchtraumas. In einer retrospektiven Studie untersuchten wir, wie häufig Nierenverletzungen im Rahmen des stumpfen Bauchtraumas vorkamen, und welche diagnostischen und therapeutischen Schritte indiziert waren. Zwischen 1976–1996 wurden 308 Patienten stationär wegen eines stumpfen Bauchtraumas behandelt. Diagnostisch kamen die Peritoneallavage (bis 1983), die Sonographie und der Combur-Test, ferner gezielt i.v.-Urograpie, CT und Angiographie zur Anwendung. Die Nierenverletzungen wurden entsprechend dem “organ injury scaling” (OIS) nach 5 Schweregraden klassifiziert. Es fanden sich 69 relevante intraabdominelle Verletzungen, darunter 36 Nierenverletzungen ab Grad 2; 20 Kinder waren polytraumatisiert. Nach dem OIS teilten wir alle 67 Nierenverletzungen auf in 28 Grad-1-(Kontusion), 22 Grad-2-(Hämatom bzw. Lazeration 〈 1 cm), 8 Grad-3-(Lazeration ohne Urinaustritt), 5 Grad-4-(Lazerationmit Kelchbeteiligung bzw. vaskuläre Läsion), 1 Grad-5-Verletzung (Nierenzertrümmerung bzw. Devaskularisation) und 3 Läsionen der ableitenden Harnwege. Im Screening und in der Verlaufskontrolle erwiesen sich Sonographie und Harnanalyse als die optimalen diagnostischen Mittel. Ab Grad 2 war das CT in der Diagnostik am zuverlässigsten, so dass die i.v.-Urographie in den Hintergrund trat. Bei fehlender Kontrastmittelausscheidung im CT ist auf jeden Fall eine Angiographie indiziert. Nur in 10 Fällen war die operative Therapie notwendig. Im Verlauf der Jahre entwickelte sich ein Konzept zugunsten eines abwartenden Verhaltens mit sekundären, z. T. minimal-invasiven Eingriffen zum elektiven Zeitpunkt. Ab Grad 4 ist die operative Versorgung der Verletzungen, sei es als minimal-invasive Maßnahme, zwingend.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1619-7089
    Keywords: Key words: Thyroid carcinoma – Thyroid nodules – Fine-needle aspiration biopsy – Ultrasonographic guidance – Preoperative management
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The aim of this study was to determine the value, advantages and limitations of ultrasound-guided fine-needle aspiration biopsy (US-FNAB) in an endemic goitre area. US-FNAB was performed on all outpatients who presented with hypoechoic and/or hypofunctional and/or growing nodules. A total of 4518 US-FNABs were performed and 718 patients from this series underwent surgery. Cytological results of the primarily performed US-FNAB of these patients were compared retrospectively with the histological results. US-FNAB results were grouped as (1) non-malignant (n=303), (2) non-malignant follicular proliferation (n=177), (3) malignancy cannot be ruled out (n=133), (4) malignant (n=61), (5) inadequate (n=34), and (6) sampling error; biopsy of a non-malignant nodule (n=10). Nodules as small as 5 mm in diameter could be biopsied, gaining representative material. US-FNAB found a malignant or suspicious cytology in 65 out of 87 cases with malignant histology (74.71%). Diagnosis of early tumour stages was often possible: 12 of 18 thyroid carcinomas biopsied and smaller than 10 mm in diameter had malignant or suspicious cytology (groups 3 and 4). US-FNAB was performed incorrectly within non-malignant nodules in ten patients (1.39%) with multinodular goitre (ten papillary carcinomas, nine smaller than 10 mm). Regarding the cytology of groups 1 and 2 as benign and those of groups 3 and 4 as malignant, US-FNAB performance was as follows: sensitivity 87.84%, specificity 78.50%, negative predictive values 98.13%, positive predictive values 33.51% and accuracy 79.53%. Biopsies with inadequate material were obtained in 4.73% of all biopsies. No major adverse effects occurred. Re-biopsies in 61 cases did not alter the cytological outcome in those cases where adequate material was obtained. US-FNAB is a valuable method in the pre-operative assessment of thyroid nodules in order to select patients for surgery, as malignancy can often be detected even in early tumour stages. However, even with ultrasonographic guidance, the minimal tumour size detectable by US-FNAB is around 5 mm. The cytological interpretation in cases with regression and microfollicular proliferation also sets limits on the method. However, patients with non-malignant cytologies can be followed up safely by sonography due to the high NPV of US-FNAB as long as thyroid nodules do not become larger. Re-biopsies seem to be of limited value as long as adequate material was obtained by US-FNAB.
    Type of Medium: Electronic Resource
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