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  • 1
    ISSN: 1573-093X
    Keywords: Solar EUV Emission Lines ; Coronal Heating ; Solar Wind Acceleration ; EUV Spectrometer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The instrument SUMER - Solar Ultraviolet Measurements of Emitted Radiation is designed to investigate structures and associated dynamical processes occurring in the solar atmosphere, from the chromosphere through the transition region to the inner corona, over a temperature range from 104 to 2 × 106 K and above. These observations will permit detailed spectroscopic diagnostics of plasma densities and temperatures in many solar features, and will support penetrating studies of underlying physical processes, including plasma flows, turbulence and wave motions, diffusion transport processes, events associated with solar magnetic activity, atmospheric heating, and solar wind acceleration in the inner corona. Specifically, SUMER will measure profiles and intensities of EUV lines; determine Doppler shifts and line broadenings with high accuracy; provide stigmatic images of the Sun in the EUV with high spatial, spectral, and temporal resolution; and obtain monochromatic maps of the full Sun and the inner corona or selected areas thereof. SUMER will be flown on the Solar and Heliospheric Observatory (SOHO), scheduled for launch in November, 1995. This paper has been written to familiarize solar physicists with SUMER and to demonstrate some command procedures for achieving certain scientific observations.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-093X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract SUMER – the Solar Ultraviolet Measurements of the Emitted Radiation instrument on the Solar and Heliospheric Observatory (SOHO) – observed its first light on January 24, 1996, and subsequently obtained a detailed spectrum with detector B in the wavelength range from 660 to 1490 Å (in first order) inside and above the limb in the north polar coronal hole. Using detector A of the instrument, this range was later extended to 1610 Å. The second-order spectra of detectors A and B cover 330 to 805 Å and are superimposed on the first-order spectra. Many more features and areas of the Sun and their spectra have been observed since, including coronal holes, polar plumes and active regions. The atoms and ions emitting this radiation exist at temperatures below 2 × 106 K and are thus ideally suited to investigate the solar transition region where the temperature increases from chromospheric to coronal values. SUMER can also be operated in a manner such that it makes images or spectroheliograms of different sizes in selected spectral lines. A detailed line profile with spectral resolution elements between 22 and 45 mÅ is produced for each line at each spatial location along the slit. From the line width, intensity and wavelength position we are able to deduce temperature, density, and velocity of the emitting atoms and ions for each emission line and spatial element in the spectroheliogram. Because of the high spectral resolution and low noise of SUMER, we have been able to detect faint lines not previously observed and, in addition, to determine their spectral profiles. SUMER has already recorded over 2000 extreme ultraviolet emission lines and many identifications have been made on the disk and in the corona.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0738
    Keywords: Key words TCDD ; EROD ; humoral immunity ; single and repeated exposures ; Antibody suppression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Previous studies have demonstrated that repeated (14 day) administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) enhances the suppression of humoral immunity in DBA/2 (Ah-low responder) mice relative to the effect seen with identical cumulative doses after a single treatment (cumulative doses of 4.2, 14.0, and 42 mg/kg). In the present studies, we have explored this phenomenon further by determining the status of several specific parameters, which might account for the increase in antibody suppression in the DBA/2 strain following repeated TCDD exposures. Included in these studies was the induction of hepatic and splenic microsomal 7-ethoxyresorufin-o-deethylase (EROD; P4501A1) activity and biodistribution of the administered TCDD into various target organs and tissues. Changes in lymphocyte subpopulations within the spleen were also assessed by flow cytometry following both single and repeated dosing. All studies made use of direct comparisons between DBA/2 (Ah-low responder) and B6C3F1 (Ah-high responder) female mice. Results of these studies demonstrate that the enhanced suppression of humoral immunity in DBA/2 mice following repeated exposure to TCDD is not directly associated with increases in liver microsomal EROD activity and does not appear to be correlated with changes in the pattern of biodistribution or amount of TCDD within the liver or spleen of these animals. In contrast, the most significant changes that occurred following repeated dosing in either strain were observed in the levels of microsomal EROD activity and immune cell ratios within the spleen. This effect was characterized as an increase in microsomal EROD activity, and a corresponding reduction in the numbers of a non-B/non-T cell population in the spleen.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1569-8041
    Keywords: cisplatin ; ovarian cancer ; paclitaxel ; sequential chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose:To examine the activity and safety of two sequentiallyscheduled chemotherapy regimens comprising four cycles of paclitaxel (pctx)200 mg/m2/3 hours then four cycles of cisplatin (cisDDP) 100mg/m2, and vice versa, in patients with previouslyuntreated advanced ovarian cancer. Patients and methods:Between January 1994 and February 1996, werecruited 30 patients to the pctx-then-cisDDP regimen and 29 tocisDDP-then-pctx, in parallel phase II trials. Results:Both regimens were predictably active with responses seenin 22 of 30 patients (OR 74%; CR 27%, PR 47%) treatedwith pctx-then-cisDDP, as against 13 of 21 patients (OR 62%; CR38%, PR 24%) treated with cisDDP-then-pctx. The OR rate to fourcycles of pctx (induction) was 43%, with 27% diseaseprogression; the OR to four cycles of cisDDP (induction) was 57%, with5% progression. However, progression rates across both induction andconsolidation phases were 16% (pctx-then-cisDDP) and 29%(cisDDP-then-pctx). Both regimens were unacceptably neurotoxic, 11 patientssuffering grade 3 sensory neurotoxicity (5 on pctx-then-cisDDP, 6 oncisDDP-then-pctx) and 20 having grade 3 deafness (9 on pctx-then-cisDDP, 11on cisDDP-then-pctx). Conclusion:The activity of these sequential regimens justifiestheir further development using the less neurotoxic platinum analoguecarboplatin, perhaps combining paclitaxel with other platinum non-crossresistant drugs.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1573-093X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract SUMER – Solar Ultraviolet Measurements of Emitted Radiation – is not only an extreme ultraviolet (EUV) spectrometer capable of obtaining detailed spectra in the range from 500 to 1610 Å, but, using the telescope mechanisms, it also provides monochromatic images over the full solar disk and beyond, into the corona, with high spatial resolution. We report on some aspects of the observation programmes that have already led us to a new view of many aspects of the Sun, including quiet Sun, chromospheric and transition region network, coronal hole, polar plume, prominence and active region studies. After an introduction, where we compare the SUMER imaging capabilities to previous experiments in our wavelength range, we describe the results of tests performed in order to characterize and optimize the telescope under operational conditions. We find the spatial resolution to be 1.2 arc sec across the slit and 2 arc sec (2 detector pixels) along the slit. Resolution and sensitivity are adequate to provide details on the structure, physical properties, and evolution of several solar features which we then present. Finally some information is given on the data availability and the data management system.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1573-093X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract This paper describes the results of comparing SERTS-3 images obtained in the transition region line of Heii 304 Å with chromospheric Hei 10830 Å absorption, with strong coronal lines of Mgix 368 Å, Fexv 284 Å and 417 Å, and Fexvi 335 Å and 31 Å, with Hα, with Caii 8542 Å, and with magnetograms in Fei 8688Hα. All of the images are illustrated, and the image reconstruction techniques used are described and evaluated. The high correlation of the Heii 304 Å and Hei 10830 Å images, originally found by Harvey and Sheeley (1977), is confirmed and is put on a quantitative basis. We find that the supergranulation network has greater contrast, and that filaments appear darker, in 10830 Å than in 304 Å. In active regions, the 304 Å line follows more closely the behavior of Hα and Caii 8542 Å than the 10830 Å line.
    Type of Medium: Electronic Resource
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