ISSN:
1600-079X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Abstract: The effect of melatonin as well as pinealectomy on the basal and K+-evoked release of vasopressin and oxytocin from the neurointermediate lobes in vitro was determined. Pineal removal resulted in a diminution of vasopressin and oxytocin release from the neurointermediate lobes in vitro. Melatonin (10−3 or 10−6 M/1) increased vasopressin and oxytocin release from neurointermediate lobes of sham-operated rats. Nevertheless, when pinealectomized rats served as donors of the neurointermediate lobes, melatonin (10−3 or 10−6 M/1) increased vasopressin release under basal conditions. For the same tissue, melatonin did not affect the oxytocin release either under basal conditions or during depolarization due to excess potassium. When 10−7 M/l melatonin was used, no changes in either vasopressin or oxytocin release were observed in vitro.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1600-079X.1992.tb00019.x
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