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  • 1
    Electronic Resource
    Electronic Resource
    Chronic exposure to 25–80-μT, 200-Hz magnetic field does not influence serum melatonin concentrations in patients with low back pain (2000)
    Copenhagen : Munksgaard
    Journal of pineal research 29 (2000), S. 0 
    Details
    ISSN: 1600-079X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: There is substantial evidence that magnetic field (MF) exposure influences melatonin secretion in animals. However, data on its influence on human melatonin levels are scarce, and seemingly contradictory. Because of its many beneficial effects, very low-frequency MF exposure is used in physiotherapy of some neurological diseases and overloading syndromes of the locomotor system. In previous studies, we observed a decrease in human serum melatonin nocturnal concentrations after exposure to MF (2.9 mT, 40 Hz), and we suggested that differences among various studies may depend on different characteristics of the applied MF. Therefore, in the present study, we examined whether or not MF of different parameters exerts the same effect. The study was performed in seven men (mean age: 36.7±3.8 years; range: 32–42) suffering from low back pain. Patients were exposed to a pulsating MF (induction: 25–80 μT; frequency: 200 Hz, modulated, automatically programmed; complex saw-like impulse shape; bipolar) generated by a Quatronic MRS 2000 apparatus (“magnetic bed”) for 3 wk (5 days/wk, twice a day at 08:00 and 13:00 hr for 8 min each), applied to the whole body in patients laying in a horizontal position. The study was performed in spring. Diurnal serum melatonin profiles were estimated 1 day before exposure to MF (baseline), and 1 day and 1 month after the last exposure. No changes in melatonin concentrations were observed either after 1 day or after 1 month following the exposure in comparison to baseline.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-079X.2000.290203.x
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  • 2
    Electronic Resource
    Electronic Resource
    Melatonin Inhibits Prostaglandin E Release From the Medial Basal Hypothalamus of Pinealectomized Rats (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of pineal research 1 (1984), S. 0 
    Details
    ISSN: 1600-079X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effects of pinealectomy and of melatonin administration on prostaglandin E synthesis in the medial basal hypothalamus were studied in male rats. Melatonin treatment significantly decreased prostaglandin E release from the medial basal hypothalamus in pinealectomized rats. The results of the present study suggest that melatonin modulates hypothalamo-hypophyseal function, at least in part, via inhibition of hypothalamic prostaglandin synthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-079X.1984.tb00222.x
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of Experimentally Induced Chronic Hyperprolactinemia on the Ultrastructure of Pinealocytes in Male Rats (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of pineal research 1 (1984), S. 0 
    Details
    ISSN: 1600-079X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The influence on the ultrastructure of pinealocytes of long-term hyperprolactinemia caused by ectopic pituitary transplants and of suppression of prolactin release by bromocriptine was examined morphometrically in male rats. Hyperprolactinemia resulted in an increase in the relative volumes of granular endoplasmic reticulum, vacuoles containing a flocculent material, mitochondria, and lipid droplets. Treatment of grafted rats with bromocriptine reversed the effects of hyperprolactinemia. However, bromocriptine had no apparent influence on the pinealocytes of intact rats. The effects of hyperprolactinemia on the ependymallike secretory process in the pinealocyte were especially pronounced.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-079X.1984.tb00215.x
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  • 4
    Electronic Resource
    Electronic Resource
    Melatonin inhibits growth of diethylstilbestrol-induced prolactin-secreting pituitary tumor in vitro: possible involvement of nuclear RZR/ROR receptors (2003)
    Oxford, UK : Munksgaard International Publishers
    Journal of pineal research 34 (2003), S. 0 
    Details
    ISSN: 1600-079X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Melatonin exerts a marked antiproliferative action in numerous experimentally-induced tumors in vivo as well as in both animal and human cell lines in vitro. However, the mechanisms of oncostatic action of melatonin is not clear, and the involvement of both membrane and nuclear receptors are suggested. Therefore, the aim of this study was to investigate effects of melatonin, and both agonist (CGP 52608), and antagonist (CGP 55644) of RZR/ROR nuclear receptors on the growth of diethylstilbestrol-induced rat prolactin-secreting pituitary tumor cells in vitro.Pituitary tumors were induced by subcutaneous implantation of a single silastic capsule containing 10 mg of diethylstilbestrol in 4-wk-old male Fischer 344 rats. Four months after the implantation of capsules the animals were killed by decapitation, pituitary tumors were aseptically removed, mechanically dispersed, and enzymatically digested with 0.2% collagenase and 0.2% hyaluronidase. The cells (6 × 105 cells/well) were incubated for 24 hr in the presence of melatonin, CGP 52608, CGP 55644 and CGP 55644 plus melatonin (at the concentrations of 107 and 10−9 m) at 37°C in the humidified atmosphere of 95% air and 5% CO2. The group with the addition of solvent only served as control. The growth of cell was measured using the EZ4U system. Statistical analysis was performed using ANOVA followed by LSD test.Both melatonin and CGP 52608 significantly suppressed growth of tumor cells in vitro in both used concentrations. CGP 55644 stimulated growth of tumor cells and blocked the inhibitory effects of melatonin in vitro.Results of the present study as well as other experimental evidence strongly support the hypothesis that both membrane and nuclear receptors are involved in the oncostatic action of melatonin, and indicate that nuclear signalling plays an important role in this process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-079X.2003.00046.x
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  • 5
    Electronic Resource
    Electronic Resource
    Editorial (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of pineal research 1 (1984), S. 0 
    Details
    ISSN: 1600-079X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-079X.1984.tb00189.x
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  • 6
    Electronic Resource
    Electronic Resource
    Serum melatonin circadian profiles in women suffering from cervical cancer (2005)
    Oxford, UK : Munksgaard International Publishers
    Journal of pineal research 39 (2005), S. 0 
    Details
    ISSN: 1600-079X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract:  Although there is an increasing evidence that the pineal gland may play a role in human malignancy, the studies on melatonin concentrations in different types of malignant tumors brought about controversial results. However, changes in melatonin concentrations have been observed in some types of human malignant tumors. Therefore, we decided to study the circadian melatonin rhythm in patients suffering from cervical cancer in different stages of progression and to compare them with those in subjects free from neoplastic disease. A total of 45 women were analyzed in this study. The subjects were divided into two groups. The first group consisted of 31 patients [mean age 52.1 ± 1.8 yr (mean ± S.E.M.), range 32–77 yr] with cervical cancer in various stages of the disease. The second group consisted of 14 healthy volunteers [mean age 53.5 ± 2.0 yr (mean ± S.E.M.), range 42–63] who served as the control group. Blood samples were collected at 08:00, 12:00, 16:00, 20:00, 22:00, 24:00, 02:00, 04:00, 06:00, and 08:00 hours. Melatonin concentration was measured by immunoenzymatic method. There were significant differences in circadian melatonin profiles as well as in the area under curve among the two studied groups. Melatonin concentrations were significantly lower in cancer patients in comparison with healthy individuals. Taking into consideration stage of the cervical cancer significantly lower melatonin secretion has been found in all subgroups of patients in comparison with that of tumor-free control group. Additionally, nocturnal melatonin concentrations as well as area under curve were significantly lower in advanced stage of cancer (stages 3 and 4) in comparison with patients with preinvasive cancer (stage 0) at 24:00, 02:00, and 04:00 hours and patients with stage 1 disease at 02:00 and 04:00 hours. The results of the present study indicate that the presence of cervical cancer influences melatonin levels in women. Moreover, stage dependence in reduction of melatonin concentrations has been found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-079X.2005.00221.x
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  • 7
    Electronic Resource
    Electronic Resource
    Failure of Melatonin To Inhibit the Mitotic Activity of Regenerating Adrenal Cortex in Rats (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of pineal research 4 (1987), S. 0 
    Details
    ISSN: 1600-079X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Although there is little evidence that melatonin may have a direct antimitotic effect on various cells, it has been shown that this pineal compound may influence the cell proliferation of either normal or neoplastic cells. Therefore, the influence of melatonin on the mitotic activity of regenerating adrenal cortex of rats was studied. The mitotic activity was counted in the adrenal cortex or rats on days 2, 7, and 12 following enucleation of the adrenals. Melatonin did not influence the mitotic activity of regenerating adrenal cortex in the rat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-079X.1987.tb00856.x
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  • 8
    Electronic Resource
    Electronic Resource
    Effects of Long and Short Photoperiod on the Ultrastructure of Pinealocytes of the Cotton Rat (Sigmodon hispidus) (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of pineal research 3 (1986), S. 0 
    Details
    ISSN: 1600-079X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The ultrastructure of the pinealocytes of wild-captured cotton rats (Sigmodon hispidus) housed in either long or short photoperiod was examined. Quantitative comparison of selected pinealocyte organelles revealed larger relative volumes of mitochondria, granular endoplasmic reticulum and ribosomes, Golgi apparatus, and inclusion bodies, as well as a higher number of dense-core vesicles in the animals kept in short photoperiod (LD 8:16) as compared to those in animals kept in long photoperiod (LD 16:8). These observations suggest that restricting the amount of light to which animals are exposed activates pinealocytes of the cotton rat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-079X.1986.tb00755.x
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  • 9
    Electronic Resource
    Electronic Resource
    Chronic exposure to 2.9 mT, 40 Hz magnetic field reduces melatonin concentrations in humans (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of pineal research 25 (1998), S. 0 
    Details
    ISSN: 1600-079X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Karasek M, Woldanska-Okonska M, Czernicki J, Zylinska K, Swietoslawski J. Chronic exposure to 2.9 mT, 40 Hz magnetic field reduces melatonin concentrations in humans. J. Pineal Res. 1998; 25:240–244. © Munksgaard, Copenhagen〈section xml:id="abs1-1"〉〈title type="main"〉AbstractDiurnal rhythm of serum melatonin concentrations was estimated in 12 men with low back pain syndrome before and after exposure to a very low-frequency magnetic field (2.9 mT, 40 Hz, square wave, bipolar). Patients were exposed to the magnetic field for 3 weeks (20 min per day, 5 days per week) either in the morning (at 10: 00 hr) or in the late afternoon (at 18: 00 hr). Significant depression in nocturnal melatonin rise was observed regardless of the time of exposure. This phenomenon was characteristic for all the subjects, although the percent of inhibition of melatonin secretion varied among the studied individuals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-079X.1998.tb00393.x
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  • 10
    Electronic Resource
    Electronic Resource
    Ultrastructure of the pineal gland of the eastern chipmunk (Tamias striatus) (1982)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 173 (1982), S. 73-86 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The ultrastructure of the pineal gland of the wild-captured eastern chipmunk (Tamias striatus) was examined. A homogenous population of pinealocytes was the characteristic cellular element of the chipmunk pineal gland. Often, pinealocytes showed a folliclelike arrangement. Mitochondria, Golgi apparatus, granular endoplasmic reticulum, lysosomes, centrioles, dense-core vesicles, clear vesicles, glycogen particles, and microtubules were consistent components of the pinealocyte cytoplasm. The extraordinary ultrastructural feature of the chipmunk pinealocyte was the presence of extremely large numbers of “synaptic” ribbons. The number of “synaptic” ribbons in this species exceeded by a factor of five to 30 times that found in any species previously reported. In addition to pinealocytes, the pineal parenchyma contained glial cells (oligodendrocytes and fibrous astrocytes). Capillaries of the pineal gland of the chipmunk consisted of a fenestrated endothelium. Adrenergic nerve terminals were relatively sparse.
    Additional Material: 25 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051730107
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