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  • 1
    Electronic Resource
    Electronic Resource
    Allergen Challenge Alters Intracellular Cytokine Expression (2005)
    Oxford, UK; Malden, USA : Blackwell Science Ltd
    Scandinavian journal of immunology 62 (2005), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The pathophysiology of asthma is complex and engages cascades of events in the cytokine network. We, therefore, investigated the impact of bronchial allergen challenge in humans on the cytokine profile of circulating lymphocytes. Peripheral blood samples from 10 patients with allergic asthma were collected before and 24 h after allergen provocation. Patients who mounted a late-phase reaction were designated dual responders opposite to single responders. Whole blood cells were stimulated by mitogen and intracellular interleukin (IL)-4 and interferon (IFN)-γ were detected by flow cytometry. The allergen challenge induced a decrease in IL-4+CD4+ cells in the patients (P = 0.05), and a significant decrease (P 〈 0.05) in IFN-γ+CD4+ cells was noted in single, but not dual, responders. In addition, there was a significant difference (P 〈 0.01) with respect to the changes in the IFN-γ+CD4+ cells comparing dual and single responders. No corresponding changes were observed in CD8+ cells. The data suggest a possible on-going traffic of IFN-γ and IL-4+CD4+ lymphocytes into the bronchial mucosa in relation to an allergen challenge and generate the hypothesis that a difference exists between single and dual responders in this respect. Because the CD4+IFN-γ-producing cells have the capacity to downregulate the T-helper type 2 response, a reduced capacity in this aspect might contribute to the pathophysiology in dual responders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.2005.01641.x
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  • 2
    Electronic Resource
    Electronic Resource
    IgE-mediated sensitization to predatory mites in Swedish greenhouse workers (2003)
    Oxford, UK : Munksgaard International Publishers
    Allergy 58 (2003), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Predatory mites are used as biological pesticides worldwide for control of spider mites and other pests in greenhouses. The aim of this study was to investigate if predatory and spider mites give rise to sensitization among greenhouse workers who use biological pesticides.Methods:  Blood samples were collected from 31 greenhouse workers from Stockholm area who were using the predatory mites Phytoseiulus persimilis and Hypoaspis miles for control of pesticides. Immunoglobulin E (IgE) binding to extracts of P. persimilis and H. miles and of the spider mite Tetranychus urticae was analysed with sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS–PAGE) and immunoblotting.Results:  A total of 16 workers displayed IgE antibodies to one or more of the three mite species, 32% (n = 10) to P. persimilis, 52% (n = 16) to H. miles and 26% (n = 8) to T. urticae. At least 17 IgE binding components in the molecular weight ranging from 28 to 〉94 kDa were identified in P. persimilis. In H. miles, at least 11 components were detected, among them at least one major component at about 70 kDa. Twenty-four IgE binding components were found in T. urticae.Conclusions:  In this study we have for the first time shown that the predatory mites P. persimilis and H. miles can cause IgE-mediated sensitization among greenhouse workers. The clinical relevance of sensitization to predatory mites needs to be investigated in further studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.2003.00084.x
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  • 3
    Electronic Resource
    Electronic Resource
    Zur Bestimmung von Sympatol (1936)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 104 (1936), S. 368-368 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01470900
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    Paper (German National Licenses)
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