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  • 1
    Electronic Resource
    Electronic Resource
    Cross-correlation of solar wind parameters with sunspots (‘Long-term variations’) at 1 AU during cycles 21 and 22 (1996)
    Springer
    Astrophysics and space science 245 (1996), S. 81-88 
    Details
    ISSN: 1572-946X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Long-term variations of solar wind parameters at 1 AU are correlated with sunspots for the time interval 1973 to 1993 (solar cycles 21, 22). Using theNear-Earth Heliosphere Data ‘OMNI’ the plasma density, the magnitude of the interplanetary magnetic field, the solar wind velocity and the solar wind temperature show consistent long-term variations in each cycle (21 and 22) — pointing to specifictime-lags in the coupling between sunspots (and the underlying convection zone), the solar corona and the solar wind parameters at 1 AU (ecliptic).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637804
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  • 2
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1989)
    Springer
    Naturwissenschaften 76 (1989), S. 482-485 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00366232
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  • 3
    Electronic Resource
    Electronic Resource
    A model of the terrestrial ionosphere in the altitude interval 50–4000 km II. Molecular ions (N2 +, NO+, O2 +) and electron density (1989)
    Springer
    Earth, moon and planets 47 (1989), S. 109-163 
    Details
    ISSN: 1573-0794
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Empirical models of molecular ion densities (N2 +, NO+, O2 +) and the electron density (N e ) are presented in the altitude interval 50–4000 km as functions of time (diurnal, annual), space (position, altitude) and solar flux (F 10.7). Using observations of 6 satellites (AE-C, AE-D, AE-E, ALOUETTE-2, ISIS-1, ISIS-2), 4 incoherent scatter stations (Arecibo, Jicamarca, Millstone Hill, St Santin) and more than 700 D-region profiles, this model describes the global gross features of the ionosphere for quiet geophysical conditions (K p ≦ 3). The molecular ion densities and the electron density increase with increasing altitude up to a maximum (or several maxima) - and decrease from thereon with increasing height. Between ~80 and 200 km, the main ionic constituents are NO+ and O2 +; below ~80 km cluster ions are predominating. During local summer conditions the molecular ions and N e increase around polar latitudes and decrease correspondingly during local winter. The diurnal variations are intrinsically coupled to the individual plasma layers; in general, the molecular ion and electron densities are enhanced during daytime and depleted during nighttime (for details and exceptions, see text).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00058139
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  • 4
    Electronic Resource
    Electronic Resource
    A model of the terrestrial ionosphere in the altitude interval 50–4000 km I. Atomic ions (H+, He+, N+, O+) (1989)
    Springer
    Earth, moon and planets 45 (1989), S. 53-100 
    Details
    ISSN: 1573-0794
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract An empirical model of atomic ion densities (H+, He+, N+, O+) is presented up to 4000 km altitude as a function of time (diurnal, annual), space (position, altitude) and solar flux (F10.7) — using observations of satellites (AE-B, AE-C, AE-D, AE-E, ISIS-2, OGO-6) and rockets during quiet geophysical conditions (K p ⩽ 3). The numerical treatment is based upon harmonic functions for the horizontal pattern and cubic splines for the vertical structure. The ion densities increase with increasing height up to a maximum (depending roughly on the ion mass) and decrease beyond that with increasing altitude. Above 200 km, O+ is the main ionic constituent being replaced at approximately 800 km (depending on latitude, local time, etc.) by H+. Around polar regions the light ions, H+ and He+, are depleted (polar wind) and the heavier ones enhanced. During local summer conditions the ion densities increase around polar latitudes and correspondingly decrease during local winter, except He+ which reflects the opposite pattern. Diurnal variations are intrinsically coupled to the individual plasma layers: N+ and O+ peak, in general, during daytime, while the amplitudes and phases of H+ and He+ change strongly with altitude and latitude.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00054660
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  • 5
    Electronic Resource
    Electronic Resource
    Radial dependence of solar wind parameters in the ecliptic (1.1 R ⊙−61 AU) (1996)
    Springer
    Solar physics 169 (1996), S. 209-213 
    Details
    ISSN: 1573-093X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The radial dependencies of four solar wind parameters (plasma density N, velocity V, temperature T, and magnitude of the interplanetary magnetic field B) are derived from remote sensing data of the solar corona and from in situ measurements in the heliosphere (Helios-1, 2, Pioneer-10, 11, and Voyager-1, 2). Using doubly logarithmic scaling (‘solar wind parameter vs radial distance from the Sun’) one finds two distinct intervals in the ecliptic, i.e., an exponential section within, approximately, the inner heliosphere and a linear section - up to at least 61 AU - in the outer heliosphere.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00153841
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  • 6
    Electronic Resource
    Electronic Resource
    Oxygen effect and influence of buffer on radiation-induced tritium cleavage from phage-T2-DNA-(methyl-3H) in aqueous solution (1985)
    Springer
    Radiation and environmental biophysics 24 (1985), S. 239-249 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Summary The effect of gamma irradiation on tritium release into water (HTO) from phage T2-DNA-(methyl-3H) was studied in diluted aqueous solution. The influence of O2 and of citrate and phosphate buffer was investigated. In oxygenated solutions an enhancement ratio of 3 was found. From the linear dose yield relationsG values were calculated. In the presence of N2O tritium release was doubled, whereas tritium release decreased with increasing citrate concentration. It has been concluded that the major precursor of this tritium release is the OH radical. This was substantiated by experiments using thymine-(methyl-3H) and dimethylsulfoxide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01210931
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  • 7
    Electronic Resource
    Electronic Resource
    Biological activity of the antitumor protein neocarzinostatin coupled to monoclonal antibody by N-succinimidyl 3-(2-pyridildithio) propionate (SPDP) (1981)
    Springer
    European biophysics journal 7 (1981), S. 271-271 
    Details
    ISSN: 1432-1017
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02425402
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  • 8
    Electronic Resource
    Electronic Resource
    Selective toxicity of neocarzinostatin-monoclonal antibody conjugates to the antigen-bearing human melanoma cell line in vitro (1985)
    Springer
    Cancer immunology immunotherapy 20 (1985), S. 85-90 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Monoclonal antibodies (IgG1) against high molecular weight antigen A-1-43 on human melanoma cell line A-375 were successfully linked to the anti-tumour protein neocarzinostatin (NCS) using the heterobifunctional reagent N-succinimidyl 3-(2-pyridyldithio)-propionate (SPDP). The conjugate retained both the reactivity of the antibody and the toxicity of the drug. The antigen-bearing cell line A-375, antigen-lacking cell line MeWo and normal skin fibroblasts were exposed to NCS-monoclonal antibody conjugates. As negative control, cells were also treated with free NCS and NCS coupled to normal mouse IgG1 antibodies. Inhibition of 3H-thymidine uptake after treatment was used to measure the biological activity of the cytotoxic drug complex or substance, respectively. Comparing the inhibition dose for 50% uptake (ID50) it was found that the monoclonal antibody-drug complex is about 100 times more toxic for the antigen-bearing cell line than free NCS or normal mouse IgG1-NCS. This high toxicity is due to a local increase of drug concentration on these cells. With the two cell lines lacking the appropriate antigen no significant differences in the ID50 values were observed. A selectivity factor of 40–50 was obtained by comparing the cytotoxic effect of the monoclonal antibody-NCS conjugate upon the antigen-bearing as opposed to the antigen-lacking cell type. These data demonstrate, that the toxicity of NCS can be directed by monoclonal antibodies to human tumour cells carrying the corresponding surface antigen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00199779
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  • 9
    Electronic Resource
    Electronic Resource
    Anionradicals from 5-halouracil substituted oriented DNA after X-irradiation at low temperatures (1986)
    Springer
    Radiation and environmental biophysics 25 (1986), S. 175-181 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Conclusions The model of two initial radiation - induced radical components in oriented fibers of DNA,T − andG + [1], should be amended, for 5-halouracil substituted DNA by the finding that the primary anion is formed on the 5-halouracil base specifically but differentiates, depending on the halogen substituent, intoπ*- andσ*-forms. The occurrence of the latter appears, from theoretical calculations, to be connected with a C-halogen bond elongation. The DNA matrix apparently allows for this whereas in the corresponding single crystals of 5-bromodeoxyuridine [1] or 5-iododeoxyuridine [4] the crystal packing prevents the elongation thus allowing forπ*-anion formation only.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01221223
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  • 10
    Electronic Resource
    Electronic Resource
    ESR Spectrum of a Non-Degenerate State of the Benzene Radical Anion (1967)
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 6 (1967), S. 360-361 
    Details
    ISSN: 0570-0833
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/anie.196703602
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