ISSN:
1600-0536
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
A 15-year-old girl developed perioral dermatitis and swelling of the lips, having played a flute made of cocus wood for 2 years. Patch tests with wood shavings, as well as with subsequently isolated constituents named focus 1 and focus II. were Strongly positive. Alter complete purification, boltContact allergens were identified as isoflavan derivatives, While Cocus 1 was shown to be 7,8-dihydroxy-2,4,5trmethoxyisoflava, the structure of focus II could not be elucidated exactly. It could have been Either 7,8,3′-trihydroxy 2,4 dimethoxyisoflavan or 7,8,2-trihydroxy-3′,4-dime-thoxyoflavan The exact position of the hydroxy and methoxy group in C-2 and C-3 can be determined only by complete synthesis Of both compounds or by isolation of greater amounts of focus II for further oxidation experiments. Due t0 the stronger patch lest reaction and the higher yield cocus I in the wood, this hydroxyisoflavan must be recognized as the main contact allergen.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1600-0536.1991.tb01820.x
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