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  • 1
    Electronic Resource
    Electronic Resource
    Evaluation of Antiarrhythmic Drug Efficacy in Patients with an ICD: (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cardiovascular electrophysiology 10 (1999), S. 0 
    Details
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Antiarrhythmic Drug Efficacy in Patients with an ICD. There are a number of novel ways in which implantable cardioverter defibrillator (ICD) endpoints can he used in clinical trials to evaluate antiarrhythmic drugs. The advances in ICD technology (storage, retrieval, and accurate interpretation of ICD electrograms) expand the potential to include the use of an ICD endpoint as a clinical surrogate for sudden death. The ICD also provides the necessary safety net to test new drugs. The frequent need for‘antiarrhythmic drugs in patients already fitted with an ICD (e.g., for atrial fibrillation) necessitates knowledge of the drugs' effect on defibrillator threshold. There are interpretative problems and challenges associated with all types of ICD trials. A particular difficult issue is the degree to which the results of data on antiarrhythmic drug efficacy and safety acquired in the context of an ICD endpoint trial might he extrapolated to patient populations in which the device is not used. These and other challenging issues are discussed, with the goal of enhancing the design and interpretation of clinical trials featuring ICD endpoints.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8167.1999.tb00212.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Clinical Experience with Dual-Chamber Rate Responsive Pacemakers (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cardiovascular electrophysiology 3 (1989), S. 0 
    Details
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The development of dual-chamber rate responsive pacing is the logical consequence of technical and clinical developments and research in pacemaker technology. The first rate responsive dual-chamber pacemaker was implanted in June 1986 and the successful performance of this device encouraged manufacturers to further develop this technology. The rhythmic corrections that could be achieved were a strong argument to make use of this new technology in patients suffering from combined sinus node and AV nodal disease. DDD rate responsive pacemakers, therefore, have been implanted in 16 patients with a mean follow-up of 10.4 months. No technical complications were encountered, 2 patients died from causes not related to an arrhythmic problem. Of the 14 remaining patients, 12 are still in a dual-chamber rate responsive mode, 2 are in DDD or DDI-mode because of chronotropic competence of the sinus node. Therefore, we, conclude that dual-chamber rate responsive pacing is a reliable mode for long-term physiological pacing. Different features that can be included in a DDDR pacemaker may widen its use so that 85% of pacemaker indications might be covered with the DDDR pacemaker.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8167.1989.tb01551.x
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Use of Amiodarone in the Management of the Wolff-Parkinson-White Syndrome (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cardiovascular electrophysiology 4 (1986), S. 0 
    Details
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The ayitiarrhythmic properties of amiodarone in WPW-syndrome depend on several simultaneously active mechanisms. Its electrophysiologic properties lead to reduction of excitabUity, lengthening of refractory periods and slowing of conduction. With these effects, it reduces premature ectopic beats and thus initiating events for tachycardias. The ventricular response during atrial fibrillation will be reduced in most but unfor-tunately not all patients and tachycardia cycle length will be prolonged. Therefore amiodarone seems to be the drug of choice in WPW-syndrome if there was not a high incidence of side-effects and an extremely long tissue half-life. The prescription has therefore to be made with caution since if once applied, its effects are not immediately renersible. Hoioever, in some cases it offers an alternative for surgery of IVPW.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8167.1986.tb01727.x
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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