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  • 1
    Electronic Resource
    Electronic Resource
    Current status of dialytic therapy in Korea (2003)
    Melbourne, Australia : Blackwell Science Pty
    Nephrology 8 (2003), S. 0 
    Details
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: SUMMARY:  The status of dialytic therapy in Korea at the end of 2001 was reported by the end-stage renal disease (ESRD) registry committee of Korean Society of Nephrology, where data were collected through an internet on-line registry program. The number of dialysis centres was 335 and the number of haemodialysis machines was 5529. The total number of patients with dialysis was 23 057 (haemodialysis 17 568, peritoneal dialysis 5489). Prevalence and incidence of dialysis patients were 477.5 and 96.4 patients per million population. The most common primary cause of end-stage renal diseases was diabetic nephropathy (41.5%), hypertensive nephrosclerosis (15.4%), and chronic glomerulonephritis (13.6%). Eighty-six percent of haemodialysis patients were on dialysis therapy three times a week, the mean urea reduction ratio was 66.7 ± 8.68% and mean Kt/V was 1.250 ± 0.292 in male patients; 1.526 ± 0.361 in female patients. The technical survival of haemodialysis in 5 years was 30.2% and peritoneal dialysis was 13.8%. The common complication of haemodialysis patients was hypertension (43.3%), gastrointestinal disease other than peptic ulcer (8.0%), congestive heart failure (7.6%), and of peritoneal dialysis patients were also hypertension (28.8%), congestive heart failure (5.0%), and peritonitis (4.8%). The most common causes of death were cardiac diseases (26.9%), vascular diseases, including cerebrovascular accidents (22.7%), and infection (17.8%).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1440-1797.8.s.5.x
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  • 2
    Electronic Resource
    Electronic Resource
    Impact of mesangial IgA deposits in 14th-post operative-day routine renal allograft biopsies (2002)
    Oxford, UK : Blackwell Science Pty
    Nephrology 7 (2002), S. 0 
    Details
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: SUMMARY: Three hundred fourteen 14th-postoperative-day routine renal allograft biopsies were evaluated together with clinical data. Out of 314 biopsies, mesangial IgA deposits were positive in 122 biopsies (39%). According to Banff classification, the rate of acute rejection was significantly lower in mesangial IgA deposit-positive (IgA(+)) patients (7.4%) than in mesangial IgA deposit-negative (IgA(-)) patients (19.7%) on the 14th postoperative day. Thereafter, rate of biopsy-proven and clinical acute rejection was continuously lower for up to 12 months in IgA(+) patients than in IgA(-) patients. The detection rate of mesangial IgA deposits was significantly higher in human leucocyte antigen (HLA)-well-matched (HLA mismatch number was 〈3) patients than in HLA-poorly matched (HLA mismatch number was ≥3) patients. In HLA-well-matched patients, the serum creatinine levels were significantly lower in IgA(+) patients than in IgA(-) patients after 3 post-transplant months and up to 1 post-transplant year. Follow-up (mean interval: 13 months) allograft biopsies were performed in 34 patients out of 122 IgA(+) patients. In the follow-up biopsies, initially detected mesangial IgA deposits had disappeared in 22 patients (65%) out of 34 patients. Twelve patients (35%) still had mesangial IgA deposits, and all of them had clinical and pathological findings consistent with IgA nephropathy. Patients with continuous mesangial IgA deposits in the follow-up biopsies had a better renal function at 1 year and a higher 5-year graft survival rate compared with patients who lost the initially deposited IgA. The present study demonstrates that long-lasting mesangial IgA deposits in renal transplants prevent allografts from acute rejection, which leads to better graft outcome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1440-1797.7.s3.1.x
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  • 3
    Electronic Resource
    Electronic Resource
    Impact of mesangial IgA deposits in 14th-postoperative-day routine renal allograft biopsies (2002)
    Oxford, UK : Blackwell Publishing Ltd
    Nephrology 7 (2002), S. 0 
    Details
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: SUMMARY: Three hundred fourteen 14th-postoperative-day routine renal allograft biopsies were evaluated together with clinical data. Out of 314 biopsies, mesangial IgA deposits were positive in 122 biopsies (39%). According to Banff classification, the rate of acute rejection was significantly lower in mesangial IgA deposit-positive (IgA(+)) patients (7.4%) than in mesangial IgA deposit-negative (IgA(-)) patients (19.7%) on the 14th postoperative day. Thereafter, rate of biopsy-proven and clinical acute rejection was continuously lower for up to 12 months in IgA(+) patients than in IgA(-) patients. the detection rate of mesangial IgA deposits was significantly higher in human leucocyte antigen (HLA)-well-matched (HLA mismatch number was 〈3) patients than in HLA-poorly matched (HLA mismatch number was 〈3) patients. In HLA-well-matched patients, the serum creatinine levels were significantly lower in IgA(+) patients than in IgA(-) patients after 3 post-transplant months and up to 1 post-transplant year. Follow-up (mean interval: 13 months) allograft biopsies were performed in 34 patients out of 122 IgA(+) patients. In the follow-up biopsies, initially detected mesangial IgA deposits had disappeared in 22 patients (65%) out of 34 patients. Twelve patients (35%) still had mesangial IgA deposits, and all of them had clinical and pathological findings consistent with IgA nephropathy. Patients with continuous mesangial IgA deposits in the follow-up biopsies had a better renal function at 1 year and a higher 5-year graft survival rate compared with patients who lost the initially deposited IgA. the present study demonstrates that long-lasting mesangial IgA deposits in renal transplants prevent allografts from acute rejection, which leads to better graft outcome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1797.2002.tb00514.x
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  • 4
    Electronic Resource
    Electronic Resource
    Influence of Emdogain〈sup〉®〈/sup〉 Treatment onto K〈sub〉2〈/sub〉O Incorporated Calcium Metaphosphate on Osteogenic Activation (2005)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 284-286 (Apr. 2005), p. 631-634 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: As a part of the efforts to develop a suitable scaffold optimizing bone regeneration that has similar physical properties to bone, we modified calcium metaphosphate (CMP) ceramics with K2O and evaluated their efficiency as a scaffold for tissue engineered bone tissue regeneration. Macroporous CMP ceramics modified by incorporation of 5% K2O to improve biodegradability were prepared to have 250 and 450 µm average pore sizes, respectively. The modified CMP ceramics werecultured with mouse primary calvarial osteoblastic cells in osteogenic media for 2 weeks and these cell-CMP ceramic constructs with or without Emdogain treatment were implanted in the SCID mice subcutaneous pouches. After 1, 2, and 3 weeks, the degree of ectopic bone formation was evaluated. The modified macroporous CMP ceramic-cell constructs treated with Emdogain induced ectopicbone formation, whereas the modified CMP ceramic-cell constructs without Emdogain treatment induced no ectopic bone formation. This result suggests that the Emdogain treatment on cell-scaffold constructs for tissue engineered bone regeneration may be effective for osteogenic activation of attached cells
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/49/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.284-286.631.pdf
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  • 5
    Electronic Resource
    Electronic Resource
    A Simple but Effective Demineralizing Method for Osteogenic Allograft Preparation (2005)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 288-289 (June 2005), p. 249-252 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Bone regeneration with demineralized bone preparations has demonstrated its potential in grafting procedures in surgical disciplines of both medicine and dentistry. To improve the effectiveness in preparation and osteogenic regeneration, we developed a simple and rapid demineralizing method for osteogenic allograft preparation and evaluated its osteogenic effect using an ectopic bone formation assay. The rat diaphyseal cortical bones were demineralized in heated 0.6N HCl at 60° C for 10 to 30 mins using a controlled-heat ultrasonic cleaner, washed withsterilized distill water, and dehydrated with graded alcohol after 30% H2O2 treatment. The prepared grafts were implanted in rat dorsal subcutaneous pouches for 1-3 weeks and then the harvested tissue samples were prepared for routine light microscopic observation. The allografts demineralized with 60°C HCl for more than 20 mins in an ultrasonic condition were completely demineralized and effectively induced ectopic formation without specific pathologic findings. These findings suggest that demineralization with 60°C HCl for around 20 mins using a controlled-heat ultrasonic cleaner and dehydration with graded alcohol after short treatment with 30% H2O2 is a very simple but effective osteogenic allograft preparation method with minimal antigenicity and sterilizing effects
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/49/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.288-289.249.pdf
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  • 6
    Electronic Resource
    Electronic Resource
    A Comparative Study of the Porous Structure of a Scaffold for Effective Tissue-Engineered Bone Regeneration (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 361-363 (Nov. 2007), p. 935-938 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: To develop a suitable scaffold for tissue-engineered bone regeneration, we compared theefficiency of tissue-engineered bone regeneration according to the porous structure of calciummetaphosphate (CMP) ceramic scaffolds. Each scaffold was prepared with a sponge method and afoam-gel method, respectively. Both scaffolds, having either interconnected trabecular pores formedby the sponge method or fully interconnected globular pores formed by the foam-based technology,were not cytotoxic and elicited neither an immune nor an inflammatory response regardless ofgeometry and fabrication method. The fully interconnected globular porous scaffold showed morefavorable compression strength and facilitated osteogenic repair by favoring cellular attachment andosteogenic differentiation with good osteoconductivity compared to the interconnected trabecularpore structured scaffold. These results suggest that the fully interconnected globular porous structurewould be more suitable for both a bone substitute and scaffold for bioactive material-based orcell-based tissue bone regeneration
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.361-363.935.pdf
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  • 7
    Electronic Resource
    Electronic Resource
    Characterization of Bone Cell Behaviors on Collagen Grafted Hydroxyapatite Surfaces (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 361-363 (Nov. 2007), p. 1143-1146 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: In order to enhance bone cell adhesion on hydroxyapatite (HA), collagen was used as asurface-grafting material on HA substrates because the collagen is a major constituent ofconnective tissues and has been regarded as one of the most excellent coating materials for bonebonding. First, HA disks (10mmΦ x 1mm) were prepared and then collagen was immobilbized onthe HA surface using an 3-APTES coupling agent on HA disk surfaces. MC3T3-E1 osteoblastswere seeded on the collagen-grafted and non-grated HA disks and cultured in a Dulbecco’smodified eagle medium containing 10% fetal bovine serum for 4 hrs to evaluate the cell adhesionon the HA samples. The osteoblasts on the collagen-grafted sample were more spread than those onthe non-grafted sample. It is believed that collagen-grafted HA surface provides suitable sites forcell attaching due to the high biocompatibility of collagen
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.361-363.1143.pdf
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  • 8
    Electronic Resource
    Electronic Resource
    Stimulatory Effect of Nano-Sized Calcium Metaphosphate Particles on Proliferation and Osteoblastic Differentiation of Human Bone Marrow Mesenchymal Stem Cells (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 361-363 (Nov. 2007), p. 1177-1180 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Recently, nanomaterials have received considerable attention because of their potentialapplications in the biomedical field. In the present study, we investigated the effects of nano-sizedcalcium metaphosphate (CMP) particles (50 nm) compared with micro-sized CMP particles (200-500nm and 10 μm) on the proliferation and osteoblastic differentiation of human bone marrow stem cells(BMSCs). BMSCs were challenged with CMP particles with different sizes for 3, 5, and 7 days. Ananalysis of the proliferation revealed that the nano-sized CMP particles (50 nm) stimulated theproliferation of BMSCs up to 27.79% compared to the untreated control. This stimulatory effect ofthe nano-sized CMP particle was dose-dependent. CMP particles appeared to adhere on the surface ofBMSCs but this did not cause distinguishable morphological changes. Moreover, all CMP particles(50 nm to 10 μm) were capable of stimulating an osteoblastic differentiation of BMSCs as accessedby alkaline phosphatase (ALP) and von Kossa stainings. Further molecular analysis revealed that allthe CMP particles induced an expression of osteoblast-related genes such as osteocalcin (OC) andcollagen I (Col I). Taken together, our data demonstrate that nano-sized CMP particles have thepotential to stimulate the proliferation and osteoblastic differentiation of BMSCs
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.361-363.1177.pdf
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  • 9
    Electronic Resource
    Electronic Resource
    Thermal Ablation Effects of Duplex Stainless Steel Thermo-Implants (2003)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 426-432 (Aug. 2003), p. 3249-3254 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/07/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.426-432.3249.pdf
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  • 10
    Electronic Resource
    Electronic Resource
    Preparation of Biodegradable Porous Calcium Metaphosphate Granules as Bone Filler by Starch Consolidation (2005)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 284-286 (Apr. 2005), p. 369-372 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Porous calcium metaphosphate granules for bone fillers were prepared by starchconsolidation with baking powder and surfactant. Paste for foaming was prepared by the mixing of calcium metaphosphate powder and water with the various amount of starch (10~20㎛ size), where solid contents 30%, 45%, 60% of the paste. In order to obtain the optimum micro/macro porous structure, the appropriate contents of baking powder and surfactant at a fixed content of starch wereexamined. In order to examine the content of baking powder on pore morphology, the baking powder was added 60, 180, and 300 wt% of the paste at fixed content of starch. And then, in order to investigate the effect of surfactant on porous structure, surfactant was added 0.035, 0.1, and 0.16 wt% of paste weight at fixed content of starch and baking powder. Foaming was conducted using microwave method, and foamed samples were sintered at 900 ºC. The sintered porous blocks withstarch only showed uneven and closed macro pores without any micro pores. However, the sintered porous blocks with starch, baking powder, and surfactant showed homogeneous micro and macro porous structures ranging 20~60, and 300~1000 ㎛ in pore size, respectively. The porosity was increased with the increase of surfactant up to about 70 %
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/49/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.284-286.369.pdf
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