ISSN:
1434-0879
Keywords:
Hypercalciuria
;
Dietary fibres
;
Parathyroid hormon
;
1,25-dihydroxyvitamin D
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary In the present study Farnolith® (a granular powder consisting of different dietary fibres) was given to normals (n=6), patients suffering from absorptive hypercalciuria type I (n=6) and to one patient suffering from renal hypercalciuria. Farnolith binds calcium and reduces the calcium absorption from the intestine. In normals the urine- and serum parameters of calcium metabolism (total-and ionised calcium, parathyroid hormone and vitamin-D-metabolites) remained unchanged. In patients suffering from absorptive hypercalciuria type I a significant reduction of hypercalciuria was found; oxalic acid excretion had decreased as well. Lowered parathyroid hormone values returned to normal, vitamin-D-metabolites remained unaffected. In one patient suffering from renal hypercalciuria parathyroid hormone and 1,25-dihydroxy-vitamin D values increased, calcium excretion had not decreased, though. Our investigation shows that Farnolith® is suitable for the treatment of absorptive hypercalciuria. Calcium homoeostasis is returned to normal by Farnolith®, at the same time it does not produce secondary hyperoxaluria (as e.g. sodium cellulose phosphate). Patients with primary renal calcium loss should not be treated by Farnolith.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00280025
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