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  • 1
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Parmi les 26 patients qui avaient eu un pontage coronarien associé à une chirurgie abdominale dans notre institution entre 1977 et 1992, neuf avaient une maladie coronarienne sévère associée à un cancer gastrique stade I UICC. Le pontage coronarien a été suivi d'une gastrectomie à visée curatrice soit en un (premier dans l'ordre chronologique, groupe A=4), soit en deux temps (groupe B=5). La chirugie cardiaque a précédé la chirurgie gastrique dans tous les cas, et dans le groupe B, l'intervalle entre les deux interventions a été de 2 à 7 semaines. Il n'y avait aucune différence significative entre les deux groupes en ce qui concerne l'âge, le sexe, l'état préopératoire, la classification NYHA, les antécédents d'infarctus du myocarde, la fraction d'éjection, l'indexe cardiaque, le nombre de vaisseaux atteints ou le nombre de greffons utilisés. Il n'y avait aucune différence entre les deux groupes en ce qui concerne la perte sanguine pendant l'intervention gastrique (A: 649±194 ml; B; 842±326 ml) ou la durée de l'intervention (A: 371±106 min; B: 343±46 min). Deux patients dans le groupe A ont eu une complication postopératoire (un cas d'arythmie, et un autre cas, fatal, de fuite anastomotique). Il y a eu quatre complications chez les patients du groupe B (trois cas d'hyperbilirubinémie transitoire, un cas d'hémorragie postopératiore, sans aucune mortalité). La durée d'hospitalisation postopératoire n'a pas été significativement plus longue chez les patients du groupe B (A: 41.7±22.7 jours; B: 46.0±25.0 jours). En conclusion, la chirurgie coronarienne et gastrique peut être faite simultanément avec sécurité, mais une surveillance et une thérapeutique périopératoire rigoureuse sont nécessaires.
    Abstract: Resumen De 26 pacientes sometidos tanto a “bypass” coronario y a cirugía abdominal en nuestra institución entre 1977 y 1992, 9 exhibían severa enfermedad coronaria asociada con cáncer gástrico en estadío I (UICC). Estos casos fueron tratados con “bypass” coronario seguido de operación curativa para su cáncer gástrico; los primeros 4 pacientes recibieron cirugía en dos etapas (Grupo A), en tanto que los últimos cinco pacientes recibieron cirugía simultánea (Grupo B). La cirugía cardíaca fue realizada primero en todos los pacientes, y en los del Grupo A el intervalo entre los dos procedimientos fue de 2–7 semanas. No se encontraron diferencias significativas entre los dos Grupos en cuanto a características preoperatorias: sexo, edad, complicaciones preoperatorias, clase NYHA (New York Heart Association), infarto miocárdico previo, fracción de eyección, índice cardíaco, número de vasos afectados o número de injertos. No se hallaron differencias significativas entre los dos Grupos en cuanto a pérdida de sangre durante la operación gástrica (A: 649±194 ml; B: 842±326 ml) o el tiempo operatorio (A: 371±106 min; B: 343±46 min). Dos pacientes del Grupo A presentaron complicaciones postoperatorias (1 caso de arritmia, y 1 murió de sepsis por falla de la sutura). Por el contrario, 4 pacientes del Grupo B desarrollaron complicaciones (3 casos de hiperbilirrubinemia y 1 caso de hemorragia postoperatoria: ninguno murió). La estancia postoperatoria después de la gastrectomía no resultó prolongada en el Grupo B, en comparación con el Grupo A (A: 41.7±22.7; B: 46.0±25.0 días). En conclusión, se pueden realizar en forma segura el procedimiento de “bypass” coronario y de cirugía gástrica, aunque es indispensable un cuidadoso manejo del paciente.
    Notes: Abstract Or 26 patients who underwent both coronary artery bypass grafting and abdominal surgery at our institution between 1977 and 1992, nine had severe coronary artery disease associated with UICC stage I gastric cancer. They were treated by coronary artery bypass grafting followed by a curative operation for gastric cancer, the initial four patients underwent two-staged surgery (group A), and the most recent five patients underwent simultaneous surgery (group B). The cardiac surgery was performed first in all patients, and in group A the interval between the two procedures was 2 to 7 weeks. There were no significant differences between the two groups in terms of preoperative characteristics: sex, age, preoperative complications, NYHA class, prior myocardial infarction, ejection fraction, cardiac index, number of vessels diseased, or number of grafts. There were no significant differences between the two groups in terms of blood loss during the gastric operation (A: 649±194 ml; B: 842±326 ml) or the operating time (A: 371±106 minutes; B: 343±46 minutes). Two group A patients had postoperative complications (one had arrhythmia, and one died of sepsis caused by sutural insufficiency). On the other hand, four group B patients had complications (three cases of transient hyperbilirubinemia and one case of postoperative bleeding: none died). The postoperative hospital stay after gastrectomy was not prolonged in group B compared with group A (A: 41.7±22.7 days; B: 46.0±25.0 days). In conclusion, simultaneous procedure of coronary artery bypass grafting and gastric surgery can be performed safely, although careful management is indispensable.
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  • 2
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé But: La clairance maximale du vert d'indocyanine (ICG Rmax) est peut être un des paramètres les plus importants pour mesurer la fonction hépatique. La méthode utilisée pour l'analyser, cependant, comporte des imperfections et on obtient une valeur anormale chez environ 15% des patients. Nous avons trouvé une nouvelle méthode pour mesurer l'ICG Rmax en utilisant un instrument dit de «clairomètrie» (RK-1000 de Sumitomo Co Japon) qui mesure continuellement la concentration de l'ICG par un senseur optique en forme de bout de doigt. Patients: Vingt patients ont été examinés. Les diagnostics histologiques étaient comme suit: foie normal: 10; cirrhoses, 6; hépatite: 4. Méthodes et Résultats. Les concentrations d'ICG ont été mesurées in vivo continuellement avec le RK-1000. Pour obtenir la Rmax selon le modèle de Michaelis-Menten, la concentration en ICG dans le compartiment VLDL a été soustraite des valeurs obtenues par le RK-1000, car l'ICG se lie à de différentes protéines sériques et son taux de clairance différe de celle des autres compartiments protéiques. La vitesse de clairance a été calculée et une courbe de Michaelis a été établie. Puis on a calculé la Rmax à partir du réciproque de l'intersection de l'axe Y de la courbe Lineweaver-Burk. La Rmax des sujets ayant une maladie hépatique était significativement plus bas que celle des sujet ayant un foie normal. Conclusion: Notre nouvelle méthode de mesure la Rmax avec la RK-100 est un reflet fidèle de l'activité hépatique.
    Abstract: Resumen [Objetivo] La tasa máxima de remoción del verde indocianino (ICG Rmax) es considerada como un parámetro importante de función hepática. Sin embargo, el método de análisis tiene ciertas fallas lo cual resulta en valores anormales en alrededor del 15% de los pacientes. Hemos desarrollado un nuevo método de medición de ICG Rmax mediante un “clearance meter” (RK 1000; Sumitomo Co., Japan), que mide en forma continua la concentración de ICG utilizando un sensor óptico que se aplica sobre la punta del dedo. [Pacientes] Se analizaron 20 pacientes y el diagnóstico histológico fue: normal, 10; cirrosis, 6; hepatitis, 4. [Métodos y resultados] La concentración de ICG fue medida in vivo en forma continua con el RK-1000. Para obtener el Rmax por el modelo Michaelis-Menten, se sustrajo la concentración de ICG en el compartimiento VLDL de los valores obtenidos mediante el RK-1000, porque el ICG se liga con varias proteínas séricas y su rata de remoción en el compartimiento VLDL difiere de la de otros compartimientos proteicos. La velocídad de remoción fue calculada y se construyó un nomograma de Michaellis. El Rmax fue calculado a partir de la intersección Y en un nomograma de Lineweaver-Burk. El Rmax en individuos con enfermedad hepática fue significativamente más bajo que en aquellos con higado normal. [Conclusión] Nuestro nuevo método de medir ICG Rmax con el RK-1000 refleja en forma apropiada el estado de la función hepática.
    Notes: Abstract The maximal removal rate of indocyanine green (ICG Rmax) is considered to be an important parameter of hepatic function. However, the method of analysis has some flaws, and an abnormal value is obtained for about 15% of patients. We developed a new method of measuring the ICG Rmax with a clearance meter (RK-1000) that continuously measured the ICG concentration using a fingertip optical sensor. Twenty patients were examined. The histologic diagnosis was as follows: normal for 10, cirrhosis in 6, hepatitis in 4. The ICG concentration was measured in vivo continously with the RK-1000. To obtain the Rmax by the Michaelis-Menten model, the ICG concentration in the VLDL compartment was subtracted from the values obtained by the RK-1000 because ICG binds to various serum proteins and its rate of removal in the VLDL compartment differs from that in other protein compartments. The removal velocity was calculated and a Michaelis plot obtained. Then Rmax was calculated from the reciprocal of the y-intercept of a Lineweaver-Burk plot. The Rmax in subjects with liver disease was signficantly lower than in those with normal liver. It is concluded that our new method of measuring ICG Rmax with the RK-1000 reflects liver function appropriately.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Alterations of the left atrial/right atrial pressure gradient were determined using a Swan-Ganz thermodilution catheter in 20 patients who underwent laparoscopic cholecystectomy with 12 mmHg pneumoperitoneum (LAP) and 13 patients who underwent minilaparotomy cholecystectomy (MINI). Right and left atrial pressures were both elevated by pneumoperitoneum. A diminished or reversed left/right interatrial pressure gradient was recognized during pneumoperitoneum in 4 of the 20 patients (20%) in the LAP group, whereas it was not recognized during operation in any of the 13 patients in the MINI group. Evaluation of the elevation of intrathoracic pressure during pneumoperitoneum using peak inspiratory airway pressure or pulmonary arterial pressure could not predict the occurrence of this paradoxical interatrial pressure gradient.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The effects of pneumoperitoneum on the lower esophageal sphincter (LES) were evaluated during laparoscopic operation for esophageal achalasia. Intraoperative manometry was performed in three patients who underwent laparoscopic cardiomyectomy with Dor’s fundoplication and five patients who underwent laparoscopic cholecystectomy (LC). The LES pressure and the length of the high-pressure zone (HPZ) did not change during pneumoperitoneum in either the achalasia and the LC group. In the achalasia group the LES pressure was sufficiently decreased following completion of cardiomyectomy, and the length of the HPZ was found to be sufficiently long after completion of fundoplication. The postoperative courses of the achalasia patients were uneventful, and they have had no symptoms of achalasia or gastroesophageal reflux since the operation. Accordingly, intraoperative manometry during 12 mmHg pneumoperitoneum was considered to be available for laparoscopic surgery for esophageal achalasia.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] To clarify whether or not the anti-cell death activity of Bcl-2 is due to its regulation of ROS, we analysed the effects of Bcl-2 on the cell death induced by depletion of oxygen (less than 100 p.p.m. O2), where ROS involvement is unlikely, using rat hepatoma cell line 7316A (ref. 11) and rat ...
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  • 6
    ISSN: 1436-2813
    Keywords: volvulus ; small intestine ; distal gastrectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 51-year-old Japanese man who underwent a standard distal gastrectomy for cancer of the stomach developed abdominal pain when oral intake was commenced on the 6th postoperative day after an uneventful postoperative course. Complete obstruction of the jejunum led to a sudden deterioration in his general condition and a laparotomy was performed, revealing counterclockwise rotation of the mesenterium. The necrotic portion of the small intestine was removed, while 10 cm of the upper jejunum and 100 cm of the terminal ileum were preserved. His second postoperative course was uneventful apart from the development of “intestinal hurry,” which is now under medical control 9 months after his second laparotomy.
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  • 7
    ISSN: 1436-2813
    Keywords: CAD ; double cancers ; concomitant surgery ; CABG
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Concomitant surgical procedures for coronary artery disease and double cancers are reported. A 61-year-old man with severe triple-vessel coronary disease was found to have early gastric cancer and advanced rectal cancer. We successfully performed a concomitant coronary artery bypass graft using an extracorporeal ultrafiltration membrane and curative surgery for both cancers. Concomitant surgery thus appears to be a benefical and safe approach for the treatment of critical coronary artery disease and intraperitoneal double cancers in carefully selected patients.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1436-2813
    Keywords: Key Words: Richter hernia, drain, drainage tube
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: A case of a Richter hernia at the insertion site of the drainage tube following open abdominal surgery is reported. A 54-year-old man underwent an emergency operation for an idiopathic rectal perforation. A partial resection of the rectum and drainage using four 10-mm (outer diameter) drainage tubes with round cross sections was performed. Despite an uneventful early postoperative course, an emergency reoperation was required for peritonitis due to a bowel perforation 14 days after removing the drain inserted into the rectosacral space. A laparotomy revealed an incarcerated Richter hernia with ileal perforation through the 10-mm drainage site. The postoperative course after a partial resection of the ileum and drainage with Penrose drains was uneventful. This is the first report of a Richter hernia through the insertion site of a drainage tube in abdominal surgery. The possible occurrence of a Richter hernia in cases with postoperative drainage using large-size round drainage tubes should thus be considered in such patients.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1436-2813
    Keywords: malignant melanoma ; gallbladder ; junctional activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We present herein an usual case of primary malignant melanoma of the gallbladder in a 51-year-old man in whom an exploratory laparotomy for melena revealed six malignant melanoma lesions located in the gallbladder, main pancreatic duct, stomach, duodenum, jejunum, and a mesenteric lymph node. Total pancreatectomy was performed and histologically, junctional activity was seen only in the gall-bladder, suggesting that this was the primary site. No melanotic lesions were found on the skin or eyes. The metastases to the main pancreatic duct and gastrointestinal tract appeared likely to have occurred as a consequence of the mucosal dissemination of the tumor cells shed into the bile. The post-operative course was uneventful and combined chemotherapy was administered for 16 months. No new metastatic lesions were found until 21 months postoperatively, when metastases were detected in the brain and thoracic spinal cord. These metastatic tumors were removed surgically, but the patient died from cerebral disturbance 26 months after the initial operation. Thus, we consider that aggressive surgical therapy was effective for extending the survival time and improving the quality of life of this patient.
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  • 10
    ISSN: 1436-2813
    Keywords: Key Words: polydioxanone ; wound infection ; suture sinus ; continuous closure ; running closure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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