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  • 1
    Electronic Resource
    Electronic Resource
    Delayed-type hypersensitivity to protamine as a complication of insulin therapy (2005)
    Oxford, UK; Malden, USA : Munksgaard International Publishers
    Contact dermatitis 53 (2005), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0105-1873.2005.00456d.x
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  • 2
    Electronic Resource
    Electronic Resource
    Absence of HHV-8 DNA in hobnail hemangiomas (2002)
    Oxford, UK : Munksgaard International Publishers
    Journal of cutaneous pathology 29 (2002), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Hobnail hemangioma (HH) is a rare subtype of hemangioma that shares the morphological feature of hobnail endothelia with retiform hemangioendothelioma (RHE) and has to be considered in the differential diagnosis of Kaposi sarcoma. Since DNA of the human herpesvirus type 8 (HHV-8) has been detected in more than 90% of Karposi sarcomas and could recently be demonstrated in RHE, we sought to detect HHV-8 DNA in HH.Methods and results:  DNA from 12 HH was extracted and subjected to polymerase chain reaction analysis for HHV-8 DNA using two independent protocols with a single set of primers and a nested PCR approach, respectively. PCR amplification was performed using the LightCycler as well as using a thermocycler. HHV-8 DNA could not be detected in HH, although each sample contained DNA adaequately preserved for PCR reactions, as determined by amplification of the beta actin gene.Conclusions:  HHV-8 appears to play no rule in the pathogenesis of HH. Absence of HHV-8 DNA in HH might be important in the differential diagnosis to other vascular tumours, in particular Kaposi sarcoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0560.2002.290305.x
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  • 3
    Electronic Resource
    Electronic Resource
    Identification of aneuploidy in recurrent clear cell hidradenoma by DMA image cytometry (ICM-DNA) (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 24 (1997), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Since malignant clear cell hidradenoma (CCH) is often characterized by only slight and sometimes by absent nuclear anaplasia, even in metastases, definitive differentiation from its benign counterpart by light microscopy may be very difficult.Herein, we report the case of a 72-year-old woman suffering from a CCH on the back, which showed local recurrence following incomplete excision. By light microscopy no unequivocal signs of malignancy were found either in the primary or the recurrent tumor. However, unusual deep extension to the subcutis with some architectural disorder was seen in the latter.Identification of prospective malignancy in such cases of borderline histopathological features is one of the main indications for diagnostic DNA image cytometry (ICM-DNA). Application of this method to enzymatic cell separation specimens of the recurrence detected marked DNA-aneuploidy with a stemline ploidy of 2.60 c and single events up to 6.7 c, whereas a nearly exact diploid DNA-stemline was found in the primary.We suppose from our results that a prospective malignant CCH with aneuploid DNA-stemline has developed out of its DNA-diploid counterpart. The need for total surgical removal of apparently benign clear cell hidradenomas is further stressed by this observation.Criteria for the diagnosis of malignancy in CCH are reviewed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1997.tb00798.x
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  • 4
    Electronic Resource
    Electronic Resource
    TNFα-induced activation of eosinophil oxidative metabolism and morphology - Comparison with IL-5 (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Experimental dermatology 3 (1994), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract Human dermal mast cells are capable of releasing cytokines, particularly preformed TNFα, upon appropriate stimulation. Masl cell activation in vivo was shown to be associated with an influx and activation of inflammatory cells, initially PMN “polymorphonuclear neutrophilic granulocytes” then eosinophils. In order to learn more about the mechanisms by which TNFα is capable of activating eosinophils, in the present study the effect of TNFα on morphology and function of highly purified normal eosinophils “≥95%” was examined. As estimated by transmission and scanning electron microscopy, TNFα-stimulated eosinophils appeared to be strictly adherent and flattened exhibiting a characteristic “hemispheric” shape. TNFα induced a dose-dependent, long-lasting production of reactive oxygen species as measured by lucigenin-dependent chemiluminescence (CL). even at a concentration of 0.001 U/ml. The maximal response upon stimulation with TNFα, however, was significantly lower than optimal effects induced by IL-5. TNFα-induced responses were completely inhibited by cytochalasin B and staurosporin, and partially blocked by pertussis toxin. Separation of eosinophils by discontinuous density gradients revealed the existence of at least two hypodense eosinophil populations with a distinct susceptibility to stimulation with TNFα. Based on functional assay systems, in contrast to a significant extracellular, only a small intracellular H2O2: production was detected. Accordingly, H2O2 production, detected by an ultrastructural technique, was observed only on the outer surface of the plasma membrane in the contact zones in between adjacent cells. Extracellular as well as intracellular production of H2O2; was completely inhibited by cytochalasin B. TNFα-induced activation of eosinophils is most probably mediated by binding to the 55 kD and the 75 kD TNF-receptor since both receptor molecules could be detected by FACS analysis and immune electron microscopy using receptor-specific antibodies. However, in contrast to its effect on eosinophil oxidative response, TNFα did not induce the release of significant concentrations of eosinophil cationic protein or eosinophil peroxidase in supernatants of cytokine-stimulated eosinophils, as detected by functional as well as immunological assay systems. These results clearly indicate that TNFα represents a potent eosinophil-activating cytokine which may be of relevance in the allergic inflammatory response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0625.1994.tb00275.x
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  • 5
    Electronic Resource
    Electronic Resource
    Airborne contact dermatitis from colophony: phototoxic reaction? (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 21 (1989), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1989.tb03214.x
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  • 6
    Electronic Resource
    Electronic Resource
    Human epidermal keratinocytes are a source of soluble ICAM-1 molecules (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Experimental dermatology 1 (1992), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract A soluble form of the usually membrane-bound adhesion molecule ICAM-I was detected in supernatants derived from human epidermal keratinocytes. Specifically, supernatants harvested from long-term cultured normal human keratinocytes, or from the spontaneously immortalized keratinocyte cell line HaCaT, did not contain significant amounts of sICAM-l, but shedding of sICAM-1 was found to be markedly induced upon stimulation of keratinocytes with rh IFNγ. In contrast, cells from the two epidermoid carcinoma cell lines. KB and A431, constitutively shed significant amounts of slCAM-l even without cytokine stimulation, and sICAM-l contents in supernatants harvested from these cells were further increased upon stimulation of cells with rh IFNγ. These studies indicate, that in addition to peripheral blood mononuclear cells and human melanoma cells, human epidermal keratinocytes constitute an important cellular source of sICAM-l. By binding to leukocyte LFA-1 molecules, keratinocyte-derived sICAM-l may influence inflammatory responses in the skin. In addition, constitutive shedding of sICAM-l by transformed human keratinocytes may represent a possible mechanism by which neoplastic keratinocytes escape from cytotoxicity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0625.1992.tb00068.x
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  • 7
    Electronic Resource
    Electronic Resource
    Allelic loss at the p73 locus (1p36.33) is infrequent in malignant melanoma (1999)
    Springer
    Archives of dermatological research 291 (1999), S. 362-364 
    Details
    ISSN: 1432-069X
    Keywords: Key words Loss of heterozygosity ; Melanoma ; p73 ; Tumor suppressor gene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050423
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  • 8
    Electronic Resource
    Electronic Resource
    Gewebeeosinophilie und lokale Deposition von Eosinophilen-spezifischen Granulaproteinen Regulation und Bedeutung für die Entzündungsantwort bei der atopischen Dermatitis und anderen entzündlichen Dermatosen (1998)
    Springer
    Der Hautarzt 49 (1998), S. 176-183 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Eosinophile Granulozyten ; Eosinophilen-spezifische Granulaproteine ; Gewebeeosinophilie ; Atopische Dermatitis ; Entzündliche Dermatosen ; Key words Eosinophilic granulocytes ; Eosinophil granule proteins ; Tissue eosinophilia ; Atopic dermatitis ; Inflammatory skin diseases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Recent in vitro-studies have substantially increased our knowledge of eosinophil activation, the regulation of eosinophilia in the peripheral blood and the role of cytokines in that process. Accordingly, chemoattraction and activation of eosinophils by cytokines results in the local release of reactive oxygen species and toxic cationic granule proteins followed by local propagation of the inflammatory reaction and tissue damage. This extracellular tissue deposition of toxic granule proteins as an expression of complete activation of eosinophils, rather than only the presence of intact eosinophil granulocytes, is crucial for their functional effect in situ. Semiquantitative studies of local eosinophil granula deposition so far have been done only in atopic dermatitis and a limited number of other inflammatory skin diseases as summarized in this review. Evaluation of the pathogenetic role of eosinophils may be of potential therapeutic importance.
    Notes: Zusammenfassung In den letzten Jahren sind vornehmlich durch In-vitro-Untersuchungen eine Reihe neuer Erkenntnisse zur Eosinophilenaktivierung, zur Regulation der Eosinophilie im peripheren Blut und zur Rolle der daran beteiligten Zytokine erarbeitet worden. Danach kommt es als Ergebnis der Chemoattraktion und Aktivierung Eosinophiler durch Zytokine zur Gewebezerstörung und Förderung der lokalen Entzündungsreaktion als Folge einer lokalen Freisetzung von reaktiven Sauerstoffspezies und toxischen kationischen Granulaproteinen. Diese extrazelluläre Deposition Eosinophilen-spezifischer Granulaproteine als Ausdruck der vollständigen Eosinophilenaktivierung im Gewebe und nicht die alleinige Anwesenheit intakter Eosinophiler ist entscheidend für ihre funktionelle Effektorwirkung in situ. Zur lokalen Granuladeposition im Gewebe liegen bisher erst für die atopische Dermatitis und eine geringe Anzahl klinisch definierter Entzündungen des Hautorgans semiquantitative Untersuchungen vor, deren Ergebnisse zusammengefaßt werden. Die Kenntnis der Beteiligung Eosinophiler an der lokalen Entzündungsreaktion könnte für die Therapieplanung entzündlicher Dermatosen bedeutsam werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050724
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  • 9
    Electronic Resource
    Electronic Resource
    Chronisch bullöse Dermatose des Kindesalters Assoziation mit einer Salmonellen-Enteritis (1995)
    Springer
    Der Hautarzt 46 (1995), S. 485-489 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Chronisch bullöse Dermatose des Kindesalters ; Lineare IgA-Dermatose ; Juveniles Pemphigoid ; Juvenile Dermatitis herpetiformis ; Key words Chronic bullous disease of childhood ; Linear IgA-disease ; Juvenile pemphigoid ; Juvenile dermatitis herpetiformis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary We report on a 2-year-old girl with chronic bullous disease of childhood (CBDC). Concomitantly with a feverish gastrointestinal infection caused by Salmonella enteritidis, the child presented with lesions resembling impetigo contagiosa on the legs and face. Following antibiotic treatment with cephalosporins p.o. and flucloxacillin i.v. she developed typical symptoms of CBDC, i.e. tense blisters on erythematous skin in the perineal area, on the flexor aspects of the thighs and upper arms and on the face. Direct immunofluorescence revealed a linear IgA deposition along the basement membrane zone, confirming the diagnosis of CBDC. These lesions cleared rapidly after treatment with dapsone p.o. This case prompted us to consider new aspects of the pathogenesis, clinical entity and treatment of this rare bullous disease of childhood.
    Notes: Zusammenfassung Es wird über eine chronisch bullöse Dermatose des Kindesalters (CBDC) bei einem 2jährigen Mädchen berichtet. In direktem Zusammenhang mit einer fieberhaften Salmonellen-Enteritis traten zunächst Impetigo-contagiosa-ähnliche Hautveränderungen an den Beinen und im Gesicht auf. Nach einer Antibiotikatherapie mit Cephalosporinen p.o. und Flucloxacillin i.v. kam es zum plötzlichen Auftreten krankheitstypischer Symptome mit prallgefüllten Blasen auf gerötetem Grund am Perineum, an den Beugeseiten der Extremitäten sowie im Gesicht. Der Nachweis von linearen IgA-Depositionen entlang der Basalmembran sicherte die Diagnose einer CBDC. Unter interner Therapie mit Dapson heilten die Hautveränderungen rasch ab. Diese Kasuistik veranlaßte uns, neue Aspekte über Pathogenese, klinische Entität und Therapie dieser seltenen, bullösen Erkrankung des Kindesalters zu diskutieren.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050287
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  • 10
    Electronic Resource
    Electronic Resource
    Lokalisierte Infektion mit dem Kuhpocken-/Katzenpockenvirus Aktuelles zur Epidemiologie, Diagnostik und Therapie (1997)
    Springer
    Der Hautarzt 48 (1997), S. 918-922 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Kuhpocken ; Katzenpocken ; Epidemiologie ; Diagnostik ; Therapie ; Key words Cowpox ; Catpox ; Epidemiology ; Diagnosis ; Therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Only few human cowpox/catpox infections have been reported until now. The diagnosis of bland localized infections may be missed, if this disease is not well known. However, early diagnosis of localized cowpox/catpox infections is important, since at least immunocompromised patients are at risk of potential lethal generalization similar to generalized variola vera. Using a typical case report, the characteristics of the disease, as well as the current aspects of epidemiology, diagnosis and therapy are summarized. The characteristic finding of intracytoplasmatic inclusion bodies by light microscopy can be demonstrated in a human biopsy-specimen for the first time and greatly facilitated the diagnosis.
    Notes: Zusammenfassung Erst wenige Fälle von Infektionen mit dem Kuhpocken-/Katzenpockenvirus sind beim Menschen bisher beschrieben worden. Lokalisierte, blande verlaufende Infektionen werden nicht diagnostiziert, wenn dieses Krankheitsbild nicht gut bekannt ist. Da zumindest bei immunsupprimierten Patienten die Gefahr einer Generalisation mit potentiell letalen Verläufen ähnlich einer generalisierten Variola vera besteht, ist eine möglichst frühe Diagnose auch lokalisierter Infektionen wichtig. Anhand einer Fallbeschreibung werden die Charakteristiken der Erkrankung dargestellt und aktuelle Erkenntnisse zur Epidemiologie, Diagnostik und Therapie zusammengefaßt. Der lichtmikroskopische Nachweis von charakteristischen Einschlußkörpern war diagnostisch wegweisend und kann hier erstmals an humanem Biopsiematerial demonstriert werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050686
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