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  • 1
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We compared the pharmacokinetics, pharmacodynamics and safety profile of a new galenic formulation of propofol (AM149 1%), which does not contain soyabean oil, with a standard formulation of propofol (Disoprivan® 1%). In a randomised, double-blind, cross-over study, 30 healthy volunteers received a single intravenous bolus injection of 2.5 mg.kg−1 propofol. Plasma propofol levels were measured for 48 h following drug administration and evaluated according to a three-compartment model. The pharmacodynamic parameters assessed included induction and emergence times, respiratory and cardiovascular effects, and pain on injection. Patients were monitored for side effects over 48 h. Owing to a high incidence of thrombophlebitis, the study was terminated prematurely and only the data of the two parallel treatment groups (15 patients in each group) were analysed. Plasma concentrations did not differ significantly between the two formulations. Anaesthesia induction and emergence times, respiratory and cardiovascular variables showed no significant differences between the two treatment groups. Pain on injection (80 vs. 20%, p 〈 0.01) and thrombophlebitis (93.3 vs. 6.6%, p 〈 0.001) occurred more frequently with AM149 than with Disoprivan®. Although both formulations had similar pharmacokinetic and pharmacodynamic profiles the new formulation is not suitable for clinical use due to the high incidence of thrombophlebitis produced.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Psychiatric Research 25 (1991), S. 75-87 
    ISSN: 0022-3956
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Psychiatry Research 28 (1989), S. 227-239 
    ISSN: 0165-1781
    Keywords: Seasonal affective disorder ; cluster analysis ; depression ; seasonality
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0165-1781
    Keywords: Immune function ; depression ; lymphocyte blastogenesis ; lymphocyte subtypes ; phototherapy ; seasonal affective disorders
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Psychiatry Research 25 (1988), S. 91-100 
    ISSN: 0165-1781
    Keywords: Evoked potentials ; augmenting/reducing ; depression ; lateralization ; serotonin ; sleep deprivation
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Molecular and Cellular Neuroscience 4 (1993), S. 418-423 
    ISSN: 1044-7431
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1433-0407
    Keywords: Schlüsselwörter PMDS ; Diagnostische Kriterien ; Antidepressiva ; Lichttherapie ; Hirnstammpotentiale ; Schlafentzugstherapie ; Verhaltenstherapie ; Key words PMDD ; Diagnostic criteria ; Antidepressants ; Light therapy ; Brainstem-evoked responses ; Sleep deprivation ; Behavioral therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Even though premenstrual symptoms had been already described by Hippocrates, premenstrual dysphoric disorder (PMDD) was first mentioned as a special psychiatric diagnosis in the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) in 1994. In DSM-III-R-Appendix A is was called late luteal phase dysphoric disorder (LLPDD), Appendix A. Before this diagnosis was established based on operationalized criteria, the term premenstrual syndrome (PMS) was used for patients with severe premenstrual mood disturbances and physical symptoms. Many hypotheses about the pathophysiological mechanisms underlying PMS and PMDS led to different therapeutic strategies. While PMS was mainly treated by gynecologists, PMDD became of interest in psychiatric research. Several antidepressants, psychotherapy, sleep deprivation and light therapy have been investigated regarding their effectiveness in combatting premenstrual symptoms such as depression, tension, dysphoria and anxiety. Within the antidepressants the best findings were for selective serotonin reuptake inhibitors (SSRIs).
    Notes: Zusammenfassung Obwohl zyklusabhängige psychische und physische Beschwerden bereits von Hippokrates beschrieben wurden, wurde die prämenstruelle dysphorische Störung (PMDS) als eigenständige psychiatrische Diagnose erst im Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) im Jahr 1994 erwähnt. Davor, im DSM-III-R, Appendix A, lautete die Diagnose „late luteal phase dysphoric disorder” (LLPDD). Vor diesen auf operationalisierten Kriterien beruhenden Diagnosen wurde meist der Terminus prämenstruelles Syndrom (PMS) gebraucht, um Patientinnen mit prämenstruellen affektiven Symptomen und physischen Beschwerden zu beschreiben und diagnostizieren. Die vielen Hypothesen über die dem PMS bzw. der PMDS zugrundeliegenden pathophysiologischen Mechanismen führten zu unterschiedlichen therapeutischen Strategien. Während das PMS früher hauptsächlich von Gynäkologen behandelt wurde, ist die PMDS nun zu einem Interessensgebiet psychiatrischer Forschung geworden. Sowohl psychotrope (Antidepressiva) als auch nichtpsychotrope Substanzen sowie Psychotherapie, Schlafentzug und Lichttherapie wurden im Hinblick auf ihre Effektivität in der Behandlung von prämenstruellen Symptomen untersucht. Für die Antidepressiva liegen die besten Ergebnisse für die Gruppe der Selektiven Serotonin Reuptake Hemmer (SSRI) vor.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Opiatabhängigkeit ; Methadon ; Buprenorphin ; Erhaltungstherapie ; Key words Opioid dependence ; Methadone ; Buprenorphine ; Maintenance therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The efficacy of buprenorphine in opioid dependent patients (n=20) was compared to methadone maintained subjects (n=20) in a randomized comparison trial. Sublingual application of buprenorphine as an alternative synthetical opioid is being compared to methadone during a 24 week study period. A trend (p=0.06) could be found in the retention rate of investigated patients being maintained on a mean dosage of 63 mg oral applicable methadone (racemat of L- and D-methadone) in comparison to the group on a mean dosage of 7,3 mg buprenorphine (sublingual tablets). The dropout-rate of 11 subjects at the end of the study in the buprenorphine group was higher when compared to the dropout-rate of 5 in the methadone group. There was no significant difference between the two groups over the treatment period in respect to additional consumption of opiates, benzodiazepines and cocaine as evaluated through urine toxicology. The result in regard to compliance over the study period demonstrates that methadone appears to be the more successful oral opioid (p=0,04). Nevertheless, efficacy of buprenorphine in maintenance could be demonstrated in the remaining subjects, and further studies with higher daily doses and a higher number of subjects have to be performed.
    Notes: Zusammenfassung Im Rahmen der Erhaltungstherapie mit synthetischen Opioiden wurde über eine Studiendauer von 24 Wochen die Wirksamkeit von sublingual appliziertem Buprenorphin in Tablettenform mit oral verabreichtem Methadon bei 40 opiatabhängigen Patienten verglichen. In der randomisierten Studie wurden als Zielparameter die Retentionsrate (=Prozentanteil der Patienten, die über die gesamte Studiendauer im Untersuchungsprogramm verblieben und diese wie geplant beendet haben), Zusatzkonsum und Verbleibedauer definiert. Es ergab sich bei einer mittleren täglichen Dosis von 7,3 mg Buprenorphin und einer mittleren Dosierung von 63 mg Methadon eine Tendenz bezüglich der Retentionsrate (p=0,06) zugunsten der mit Methadon behandelten Gruppe. Die Ausfallsrate in der mit Buprenorphin behandelten Gruppe (n=20) war mit 11 Patienten im Vergleich zu 5 Patienten in der methadonbehandelten Gruppe (n=20) tendenziell höher. Hinsichtlich des Zusatzkonsumes von Opiaten, Benzodiazepinen und Kokain ließ sich kein signifikanter Unterschied zwischen den beiden während des Behandlungsverlaufes erheben. Methadon stellte sich, was die Verbleibedauer in der Studie betrifft, als die erfolgreichere Substanz dar (p=0,04). Weitere Studien mit höheren Dosierungen und größeren Fallzahlen müssen diesbezüglich weiteren Aufschluß bringen.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Affective Disorders 23 (1991), S. 173-183 
    ISSN: 0165-0327
    Keywords: Appetite ; Atypical depression ; Endogenous depression ; Seasonal affective disorder ; Sleep ; Weight
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Affective Disorders 19 (1990), S. 243-248 
    ISSN: 0165-0327
    Keywords: Depression ; Phototherapy ; Seasonal affective disorder
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
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