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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    International archives of occupational and environmental health 64 (1993), S. 593-596 
    ISSN: 1432-1246
    Keywords: Leukemia ; Lymphoma ; Formaldehyde ; Solvents ; Chlorophenols
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Jobs and exposures in woodwork may entail an elevated risk of lymphomas and leukemias. Exposures occurring in woodwork were scrutinized in a small industry-based case-referent study of four cases of Hodgkin's disease, eight cases of non-Hodgkin's lymphoma, 12 cases of leukemia, and 152 matched referents, all from the Finnish wood industry. Past exposures to wood dust, chlorophenols, terpenes, and engine exhaust, individually reconstructed through plant- and period-specific job exposure matrices, were unrelated to lymphoma/leukemia risk. Exposures to various solvents were associated with an odds ratio (OR) of 5.6 (95% confidence interval 1.0–32.0). The OR for formaldehyde was 2.5 (nonsignificant). The results are interpreted as providing limited evidence of the role of exposure to some as yet unidentified organic solvents in increasing the risk of malignant lymphomas. Formaldehyde may be another woodwork-related risk factor for some lymphomas, but the power of the study was too low for empirical confirmation of this possibility. Leukemias did not seem to be associated with any of the exposures studied.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    International archives of occupational and environmental health 70 (1997), S. 119-127 
    ISSN: 1432-1246
    Keywords: Key words Exposure ; Epidemiology ; Pulp industry ; Paper industry ; Data base
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An international data base of exposure measurements in the pulp, paper and paper product industries was constructed to be used in exposure assessment for epidemiology studies and hazard control. Industrial hygiene and biological monitoring data were collected from countries participating in the multicentric study of the International Agency for Research on Cancer. Each measurement was characterized by country, mill type and number, department, job, agent measured, sampling method, measurement result in the standard unit, duration and date of sampling, assessment of representativeness, measurer, purpose of measurements, and remarks (e.g. on measurement sites and biases). Over 31,000 measurement results on 246 different chemical agents from 13 countries were available from pulp (45% of measurements), paper/paperboard/recycling (12%) and paper product (11%) mills or from their non-production departments (23%). Most measurements (82%) were carried out after 1980. The most frequently measured group of agents was inorganic gases (35%), followed by organic compounds (25%), solvents (18%), mineral dusts (12%), metals (6%) and bioaerosols (3%). Over 90% of the measurements were without an obvious bias, but their true representativeness is difficult to assess. Concentrations of various agents, including sulfur dioxide, chlorine dioxide, carbon monoxide, nitrogen dioxide, ozone, ammonia, formaldehyde and some solvents, often exceeded current occupational exposure limits. This data base summarizes a great deal of previously unpublished exposure data, provides a unique opportunity to study exposure patterns at the international level and identifies exposure situations that require further attention and investigation.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-7225
    Keywords: Cohort study ; dioxin exposure ; Germany ; lung cancer ; males ; occupation ; total cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: In an occupational cohort study, the relation between exposure to phenoxy herbicides, and contaminants (dioxins and furans) and cancer mortality was investigated. A total of 2,479 workers from four plants in Germany were included, with a mortality follow-up until the end of 1989 (for one cohort, until the end of 1992). A total of 484 deaths were recorded yielding a standardized mortality ratio (SMR) of 101 (95 percent confidence interval [CI]=92–111) for total mortality, and an SMR of 119 (CI=100–141) for all malignant diseases. A variety of herbicides was produced, including those which are known to have been contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). High dioxin and furan exposure (in particular, exposure to TCDD, but also to higher chlorinated dioxins) had occurred in two of the four plants as shown by blood-fat measurements in a sample of workers. Mortality from all neoplasms increased with latency and was highest in the largest plant where the highest TCDD blood levels were recorded. An increased mortality in the total cohort from respiratory cancer (SMR=154, CI=115–202), cancer of the buccal cavity and pharynx (SMR=295, CI=135–560), and non-Hodgkin's lymphoma (SMR=326, CI=119–710) was observed. Our findings are consistent with results from other cohorts which showed an increased overall cancer mortality and mortality of respiratory cancer after long-term exposure to these phenoxy herbicides and dioxins.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-7225
    Keywords: anthophyllite ; asbestosis ; lung cancer ; mesothelioma ; pleural plaques
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objectives: To study the asbestos-associated risk of lung cancer according to the histological type of cancer, the time of and time since diagnosis of asbestosis, the asbestos-associated risk for cancers other than lung cancer or mesothelioma, and the predictive value of asbestos-related pleural abnormalities as regards the risk of cancer. Methods: Finnish patients with asbestosis (n=1,376) or asbestos-related benign pleural disease (n=4,887) notified as an occupational disease since 1964 were followed-up through the Finnish Cancer Registry for cancer in 1967–95. Results: Compared with the total cancer incidence in Finland, men with asbestosis had a raised risk of lung cancer (standardized incidence ratio [SIR]=6.7; 95% confidence interval [CI]=5.6–7.9), mesothelioma (SIR=32, CI=14–60) and cancer of the larynx (SIR=4.2, CI=1.4–9.8). The risk of lung cancer was similarly raised for all histological types of lung cancer (the highest in insulators) and did not change markedly over time of notification or duration of follow-up. Men with benign pleural disease had a raised risk of mesothelioma (SIR=5.5, CI=1.5–14) and a slightly elevated risk of lung cancer (SIR=1.3, CI=1.0–1.8). Among women with asbestosis, significant excess was found for lung cancer and mesothelioma. Conclusion: Asbestosis and asbestos-related benign pleural disease seem to possess different predictive values as regards the risk of lung cancer.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1573-7225
    Keywords: Breast cancer ; dioxins ; herbicides ; females ; international ; neoplasms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: The association between exposure to chlorophenoxy herbicides contaminated with dioxins and occurrence of cancer has been studied mainly in male populations. In animal experiments, gender differences have been recorded in the cancer response to administered 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Mortality and cancer incidence in an international cohort of 701 women from an International Register of Workers occupationally exposed to chlorophenoxy herbicides, chlorophenols, and dioxins is examined. Cause-specific, national death rates and cancer incidence rates were used as referents. Cancer risk was not increased overall, with a standardized incidence ratio (SIR) of 96 and 95 percent confidence interval (CI) of 64–137, based on 29 cases. Among workers exposed to those chlorophenoxy herbicides contaminated with TCDD, excess cancer incidence (for all sites) was observed (SIR=222, CI=102–422, 9 cases); this was highest in the first 10 years after exposure. No excess was observed for breast cancer, the most common cancer in this cohort. Results on cancer mortality were consistent with those on incidence.
    Type of Medium: Electronic Resource
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