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  • 1
    Electronic Resource
    Electronic Resource
    Synthesis, crystal structure, and electronic properties of (L-methionylglycinato)copper(II) (1979)
    s.l. : American Chemical Society
    Inorganic chemistry 18 (1979), S. 1543-1549 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic50196a031
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  • 2
    Electronic Resource
    Electronic Resource
    Synthesis of mixed-ligand complexes of Co^I^I and Cu^I^I with glycyl-L-tyrosine anion and cytidine
    Amsterdam : Elsevier
    Inorganica Chimica Acta 21 (1977), S. L13-L15 
    Details
    ISSN: 0020-1693
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0020-1693(00)86212-X
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  • 3
    Electronic Resource
    Electronic Resource
    114. Kardiomyotomie oder Dehnung bei der Achalasie (1978)
    Springer
    Langenbeck's archives of surgery 347 (1978), S. 623-623 
    Details
    ISSN: 1435-2451
    Keywords: Achalasia ; Dilatation ; Fundic patch operation ; Fundoplication ; Achalasie ; Dehnung ; Funduskissenoperation ; Fundoplikatio
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei Achalasiepatienten zeigen manometrische Untersuchungen nach Kardiomyotomie und Dehnung eine signifikante Reduktion des pathologisch erhöhten Sphincter- und Speiseröhren-innendruckes. Nach beiden Behandlungsmethoden können Refluxoesophagitiden auftreten. Im Tierexperiment wird deshalb der Einfluß refluxverhindernder Operationen (Funduskissenoperation, Fundoplikatio) auf den myotomierten Sphincter manometrisch untersucht. Die Funduskissenoperation bewirkt keine Sphincterdruckerhöhung, nach zusätzlicher Fundoplikatio steigt der Sphincterdruck signifikant an. Die Funduskissenoperation wird deshalb bei der Achalasie empfohlen.
    Notes: Summary After esophagomyotomy and dilatation, manometric investigation in patients with achalasia shows a marked and significant reduction of pathologically elevated lower esophageal sphincter pressure (LESP). Reflux esophagitis is a possible complication after both methods of treatment. Therefore, in foxhounds, the influence of reflux-preventing operations (fundoplication, fundic patch op.) on the sphincter after myotomy has been studied manometrically. The fundic patch operation causes no increased LESP, whereas after additional fundoplication, a significantly elevated LESP could be seen. The fundic patch operation therefore is recommended for the operative treatment of achalasia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01579406
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  • 4
    Electronic Resource
    Electronic Resource
    Hyperthyreosis factitia acuta — Geringe klinische Symptome bei drei Fällen unter β-Blocker-Behandlung (1986)
    Springer
    Journal of molecular medicine 64 (1986), S. 319-326 
    Details
    ISSN: 1432-1440
    Keywords: Thyroid hormones ; Overdose ; Intoxication ; Hyperthyroidism ; Thyroxine ; Triiodothyronine ; Reverse triiodothyronine ; Drug therapy ; Propranolol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The clinical and laboratory findings are described in three patients who ingested large amounts ofl-thyroxine (two cases) andl-thyroxine together withl-triiodothyronine and who were treated with propranolol. Serum concentrations of thyroxine (maximum values 75 µg/dl, 64 µg/dl, and 20 µg/dl, respectively; normal range 4–12 µg/dl), triiodothyronine (maximum values 837 ng/dl, 453 ng/dl, and 566 ng/dl, resp.; normal range 80–180 ng/dl), reverse triiodothyronine (maximum values 235 ng/dl, 190 ng/dl, and 65 ng/dl, resp.; normal range 10–40 ng/dl) as well as free thyroxine equivalent and free triiodothyronine equivalent were monitored daily until they reached the normal range. Statistical analysis of the kinetics of these parameters indicated that the extreme thyroxine conversion was directed toward reverse triiodothyronine, partly due to the treatment with the β-adrenergic blocker propranolol. The striking discrepancy between the high concentrations of the active hormones and the moderate clinical symptoms was most likely caused by peripheral effects of propranolol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01711950
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  • 5
    Electronic Resource
    Electronic Resource
    Acute hypothyroidism has no effect on pulmonary vascular resistance (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 530-534 
    Details
    ISSN: 1432-1440
    Keywords: Hypothyroidism ; Pulmonary circulation ; Pulmonary vascular resistance ; Hemodynamic evaluation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of acute hypothyroidism on the pulmonary circulation was studied in 9 nonobese athyreotic patients by right heart catheterization at rest and during exercise. The patients were studied while they were hypothyroid 2 weeks after ceasing triiodothyronine treatment and while they were euthyroid on replacement therapy. At rest, pulmonary blood flow [4.0±0.6 l/min vs 5.8±1.0 l/min,p〈0.01] and systolic pulmonary artery pressure [18±3 mmHg vs 23±2 mmHg,p〈0.01] were lower when the patients were hypothyroid than when they were euthyroid. The mean and diastolic pressures in the pulmonary artery and the pulmonary capillary pressures were not different among the groups. Likewise, thyroid hormone levels had no significant effect on pulmonary vascular resistance [100±25 dyn-s-cm−5 vs 90±23 dyn-s-cm−5]. With supine exercise, pulmonary blood flow [10.1±1.6 l/min vs. 13.2±2.0 l/min,p〈0.01], mean pulmonary artery pressure [25±6 mmHg vs 30±6 mmHg,p〈0.02], and systolic pulmonary artery pressure [36±6 mmHg vs 44±8 mmHg,p〈0.01] were lower when the patients were hypothyroid. The diastolic pulmonary artery pressure and the pulmonary capillary pressure were similar in both thyroid states. Again, thyroid deficiency had no effect on pulmonary vascular resistance [81±23 dyn-s-cm−5 vs 76±24 dyn-s-cm−5]. The lower systolic pressures in the pulmonary artery seen in hypothyroidism are probably due to the decreased systolic volume load of the pulmonary circulation. The data do not suggest that thyroid hormones play a role in the regulation of pulmonary vascular resistance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01719778
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  • 6
    Electronic Resource
    Electronic Resource
    Radionuclide ventriculography and hemodynamic evaluation by right heart catheterization with exercise for assessing the functional significance of coronary artery stenoses (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 571-575 
    Details
    ISSN: 1432-1440
    Keywords: Myocardial ischemia ; Coronary artery disease ; Radionuclide ventriculography ; Right heart catheterization with exercise
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A series of 13 patients with significant coronary stenoses but without prior myocardial infarction were simultaneously studied by right heart catheterization and radionuclide ventriculography to determine the extent to which abnormal responses in left ventricular ejection fraction and wall motion to maximum exercise are paralleled by abnormal left ventricular filling pressures. The correlations of the filling pressure as evaluated by the diastolic pulmonary artery pressure with both the exercise ejection fraction and the rest-to-exercise change in ejection fraction were high (r=−0.89,P〈0.01 andr=−0.76,P〈0.01, respectively). In addition, the filling-pressure response to stress separated the patients into distinct radionuclide categories. All the 7 patients with grossly abnormal filling pressures (P≥30 mmHg) developed regional wall motion abnormalities with exercise as evaluated by visual interpretation or quantitative phase analysis. These patients also had a decrease in ejection fraction from rest to exercise ranging from −9% to −32% together with an exercise ejection fraction below 50%. Conversely, these abnormalities were never found in patients with filling pressures below this threshold level. The data suggest that radionuclide ventriculography and measurement of left ventricular filling pressure with exercise yield corresponding results when assessing the functional significance of coronary stenoses in normotensive patients without prior myocardial infarction and normal global left ventricular function at rest.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01727625
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  • 7
    Electronic Resource
    Electronic Resource
    Single-compartment model analysis of thyrotropin-releasing hormone kinetics in hyper- and hypothyroid patients (1990)
    Springer
    Journal of molecular medicine 68 (1990), S. 1013-1019 
    Details
    ISSN: 1432-1440
    Keywords: Thyrotropin-releasing hormone ; RIA-TRH ; Pharmacokinetics ; Hypothyroidism ; Hyperthyroidism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The pharmacokinetics of thyrotropin-releasing hormone (TRH) were assessed following an i.v. injection in blood of ten hyperthyroid, ten hypothyroid, and six normal subjects. A single-compartment model was employed. After methanol extraction, TRH concentrations were analyzed using a specific radioimmunoassay technique combined with fast protein liquid chromatography (FPLC). As for the basal levels of TRH, no differences were observed in either study group. Peak concentrations were always present two min after the injection of TRH. In the euthyroid subjects, TRH blood levels had a half-life (t 1/2) of 6.5±0.41 min, mean±SD, whilet 1/2 was 7.2±0.62 min in the hyperthyroid andt 1/2 was 12±1.67 min (p〈0.001) in the hypothyroid patients. The metabolic clearance rate (MCR) (82.2±15.3 liters/m2/day vs. 89.8±17.2) and the volume of distribution (Vd) (7.1±4.2 liters vs. 7.3±3.4) were approximately the same in the normal subjects and in the hyperthyroid group. MCR (66.2±15.3 Iiters/m2/day) and Vd (6.2±3.3 liters) were found to be lower in the hypothyroid patients. In FPLC, when TRH was added to plasma, it eluted in one peak. Blood samples taken 5 min after TRH i.v. injection had an elution profile of 9.94 ml. These data indicate that 1) TRH has a very short half-life, 2) hypothyroidism can prolong thet 1/2 of exogenous TRH, and 3) when TRH should be used in clinical studies, the function of the thyroid gland has to be taken into consideration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01646547
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  • 8
    Electronic Resource
    Electronic Resource
    Total hip arthroplasty using an uncemented femoral component with taper design: outcome at 10-year follow-up (2000)
    Springer
    Archives of orthopaedic and trauma surgery 120 (2000), S. 407-412 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this study was to assess the clinical and radiological outcome of the cementless-system (CLS) femoral component designed by Spotorno with a taper design. Ninety-four patients (107 hips) were operated on from January 1987 to December 1988. The female/male ratio was 2/1, the mean age was 51 years (range 20–77 years). Clinical follow-up was obtained in 89 hips (83%). Five patients (7 hips, 6.5%) could not be traced. Nine patients (11 hips, 10%) had died before the minimum time of follow-up required for this study (10 years). All these hips still had their stem in place at the time of the last intermediate inquiry. The mean follow-up was 10.3 ± 0.3 years. No stem required revision. According to the Harris score, 84% of hips were rated good or excellent, 14% fair, and 2% poor. The average Harris hip score was 88 at the time of the last follow-up. Fifteen patients (17%) reported occasional thigh pain. All patients reported complete relief of pain within the first 6 months after the operation. Radiologically, 95% of stems showed stable fixation by bony ingrowth, 5% by fibrous ingrowth. Seven (9%) uncemented acetabular components showed progressive migration. Three of those cups had been replaced in the meantime. Fifty-one (65%) of the CLS stems induced either no change in femoral bone density or only patchy loss of bone density localized to zone 1 or 7 according to Gruen, while 27 (35%) of the hips showed some reduction of bone density in the proximal diaphysis of the femur (zone 2 or 6). Severe progressive osteolysis of the femoral cortex underneath the lesser trochanter was found in 4 hips (5%) with coexistent loosening of the cup. In all of these hips, the Mecron cup had been used. At a mean follow-up of 10 years, the results of the CLS femoral component are comparable with those of modern techniques of cementing in primary total hip arthroplasty and with the long-term outcomes of other uncemented stems with tapered design. The long-term fixation of the cup remains an unsolved problem.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00013771
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