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  • 1
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims : Eosinophilic heart syndromes are rare in Western countries and include endocarditis parietalis fibroplastica (EPF) and hypersensitivity myocarditis (HM). There are striking differences in natural history and morphological findings. Since diagnosis can be difficult when analysing small myocardial biopsies lacking the characteristic histological features, we studied a set of immunohistochemical markers in order to characterize the activation status of the infiltrating eosinophils to distinguish between these two entities.Methods and results : This study is based on the investigation of seven explanted hearts and one left ventricular specimen collected during implantation of a left ventricular assist device from a total of seven patients with HM. Also investigated were three right and three left ventricular specimens from five patients with EPF. We used antibodies (Ab) against EG1, and EG2, CD44, and CD69 which have been described as markers to distinguish between resting and activated eosinophils. The EG1 to EG2 ratio of eosinophils and the immunoreactivity against CD44 showed no differences between the two entities. However, eosinophils in the EPF were completely negative for CD69, whereas eosinophils reacted positively within the HM group.Conclusion : The immunohistochemical investigation of eosinophilic heart diseases using antibodies against CD69 can be a useful tool to distinguish between hypersensitivity myocarditis and endocarditis parietalis fibroplastica.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Communication Disorders 22 (1989), S. 125-135 
    ISSN: 0021-9924
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 110 (1997), S. 79-81 
    ISSN: 1437-1596
    Keywords: Key words Gunshot fatalities ; Clothing ; Suicide ; Homicide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Notes: Abstract According to an old rule still in use, gunshot suicides will rarely shoot through the clothing but will pull it aside to bare the skin. Thus, a bullet defect in the clothing would be an indicator for homicide or an accident. A total of 138 clearly defined gunshot suicides were analysed with regard to this topic. The thorax, which is commonly covered by textile, was the target for 27 suicides (19.5%). Of these 27 persons, 25 had fired through the clothing and 2 had placed the muzzle directly on the exposed skin, which represents a relative frequency of only 7%. Special features such as thick clothing or an affected state of mind did not appear to influence this behaviour. Consequently, the perforation of textile does not suggest homicide or an accident - it is not applicable as a criterion for distinguishing different modes of death. Only in the rare cases when a gunshot victim is found with intact clothing covering the entrance wound can this finding be interpreted as an indication for suicide.
    Type of Medium: Electronic Resource
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