ISSN:
1573-8221
Keywords:
N 1 -furanidylpyrimidines
;
metabolism
;
nonspecific oxidases of microsomes
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract N1-(31-Butyrolactono)-5-fluorouracil, N1-(21-furanidyl)-5-trifluoromethyluracil, and N1-(21-furanidyl)-5-fluorouracil are broken down in the rat in vivo with the liberation of free 5-fluorouracil. Rupture of the C−N bond in the molecule of N1-(21-furanidyl)-5-fluorouracil takes place in the liver microsomes. This process is stimulated in the presence of NADPH and is inhibited by SKF-525A. All three furani-dylpyrimidines studied induced differential spectra of type I in the suspension of liver microsomes, evidence of interaction of these substances with cytochrome P-450.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00799410
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