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The pharmacokinetics of 5-fluorouracil-2-C14 (1974)

Gilev, A. P. ; Meirena, D. V. ; Khagi, Kh. B. ; [et al.]

Springer

Bulletin of experimental biology and medicine 78 (1974), S. 1379-1381

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ISSN: 1573-8221

Keywords: fluorouracil ; pharmacokinetics ; radiometry

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract The dynamics of the concentration of radioactivity in the blood serum, organs, and urine was investigated after intravenous injection of 5-fluorouracil-2-C14 into rats. The preparation is rapidly absorbed from the blood into the tissues in which it accumulates rapidly in high concentrations and it is excreted quickly from the body. The half-elimination period of 5-fluorouracil in the blood is 15 min. It is excreted chiefly by extrarenal routes.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00808710

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