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  • 1
    Electronic Resource
    Electronic Resource
    Altered Expression Of Vascular Natriuretic Peptide Receptors In Experimental Hypertensive Rats (2002)
    Melbourne, Australia : Blackwell Science Asia Pty. Ltd.
    Clinical and experimental pharmacology and physiology 29 (2002), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The aim of the present study was to determine whether the regulation of vascular natriuretic peptide receptors (NPR) is related to the local renin–angiotensin system (RAS).2. Male Sprague-Dawley rats were made two-kidney, one-clip (2K1C) and deoxycorticosterone acetate (DOCA)-salt hypertensive to activate and inhibit the RAS, respectively. Another model of hypertension was induced by treatment with an inhibitor of nitric oxide synthesis, namely NG-nitro-L-arginine methyl ester (L-NAME).3. The mRNA expression of NPR-A, NPR-C, angiotensin- converting enzyme (ACE) and angiotensin AT1 receptors was determined in the thoracic aorta by semiquantitative reverse transcription–polymerase chain reaction. The particulate guanylyl cyclase activity stimulated by atrial natriuretic peptide (ANP) was also determined in the membrane fraction of the thoracic aorta.4. The plasma concentrations of ANP were increased significantly in the three models of hypertension. Plasma renin activity was increased in 2K1C hypertension, decreased in DOCA-salt hypertension and not significantly altered in L-NAME hypertension.5. The mRNA expression of NPR-A and NPR-C was decreased, whereas that of ACE and AT1 receptors was increased in 2K1C and L-NAME hypertension. The mRNA expression of NPR-A and NPR-C was increased, whereas that of ACE and AT1 receptors was decreased in DOCA-salt hypertension.6. The particulate guanylyl cyclase activity was decreased in 2K1C and L-NAME hypertension and increased in DOCA-salt hypertension.7. The vascular expression of NPR may be reciprocally regulated by local RAS activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1440-1681.2002.03647.x
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  • 2
    Electronic Resource
    Electronic Resource
    Dendroaspis Natriuretic Peptide Administered Intracerebroventricularly Increases Renal Water Excretion (2002)
    Melbourne, Australia : Blackwell Science Asia Pty. Ltd.
    Clinical and experimental pharmacology and physiology 29 (2002), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effects of intracerebroventricular (i.c.v.) infusion of Dendroaspis natriuretic peptide (DNP) on renal function were examined in anaesthetized rats. The results were compared with those obtained following intravenous (i.v.) infusion of the same dose of DNP.2. Urine volume was increased four- to six-fold over basal values by i.c.v. infusion of DNP (6 pmol/min). Urine osmolality was decreased, whereas sodium excretion was not significantly altered. Intravenous infusion of the same dose of DNP had little effect on urinary water excretion. Neither arterial pressure nor heart rate was changed significantly by either i.v. or i.c.v. infusion of DNP. Glomerular filtration rate, measured by creatinine clearance, remained unaltered.3. The diuretic response to i.c.v. DNP was markedly attenuated in rats that were deprived of their water supply for 3 days before the experiment.4. These results suggest that DNP can act within the central nervous system to increase renal water excretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1440-1681.2002.03631.x
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  • 3
    Electronic Resource
    Electronic Resource
    Indomethacin decreases particulate guanylyl cyclase activity in rat kidney (2004)
    Oxford, UK : Blackwell Science Pty
    Clinical and experimental pharmacology and physiology 31 (2004), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Effects of non-steroidal anti-inflammatory drugs on the local atrial natriuretic peptide (ANP) and nitric oxide (NO) systems in the kidney were investigated.2. Male Sprague-Dawley rats were treated with indomethacin (5 mg/kg, every 12 h, i.p.) for 2 days. The expression of ANP and natriuretic peptide receptor-A (NPR-A) mRNA was determined in the kidney, as was that of endothelial NO synthase (NOS) proteins. Particulate and soluble guanylyl cyclase activities were determined separately.3. Following treatment with indomethacin, urinary sodium excretion decreased significantly. Although the renal expression of ANP was not changed significantly, that of NPR-A decreased significantly. The expression of NOS increased significantly. Particulate guanylyl cyclase activity was decreased, whereas the activity of soluble guanylyl cyclase was increased. The catalytic activity of Na+/K+-ATPase was increased, with no significant changes in its expression. The expression of the type 3 Na/H exchanger and Na–K−2CL cotransporters increased significantly.4. The indomethacin-induced decrease in urinary sodium excretion may be attributed, at least in part, to decreased activity of the local ANP/cGMP system. The increased activity of the NO/cGMP system may be a compensatory response to the diminished activity of the prostaglandin system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.2004.03978.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Caffeine Decreases The Expression of Na+/K+-Atpase and the Type 3 Na+/H+ Exchanger In Rat Kidney (2002)
    Melbourne, Australia : Blackwell Science Pty
    Clinical and experimental pharmacology and physiology 29 (2002), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The aim of the present study was to explore the mechanisms underlying the renal effects of caffeine.2. Male Sprague-Dawley rats were treated with caffeine, consisting of a single oral bolus (0.2%, 20 mL/kg) followed by supplementation in drinking water (0.2%) for 1 day. Rats treated the same but given water without caffeine served as controls.3. The expression of α1- and β1-subunits of Na+/K+-ATPase, the type 3 Na+/H+ exchanger (NHE3) and aquaporin-1 was determined in the kidney by western blot analysis.4. To explore possible involvement of local humoral mediators, the tissue expression of nitric oxide synthase (NOS) proteins was determined by western blot analysis and the expression of atrial natriuretic peptide (ANP) mRNA was determined by semiquantitative reverse transcription–polymerase chain reaction.5. Following treatment with caffeine, the expression of α1- and β1-subunits of Na+/K+-ATPase, as well as that of NHE3, was decreased. Accordingly, the catalytic activity of Na+/K+-ATPase was decreased. In contrast, the expression of aquaporin-1 was not altered significantly.6. The expression of the endothelial isoform of NOS was increased, along with tissue nitrite/nitrate levels. The expression of ANP mRNA was increased.7. It is suggested that caffeine decreases Na+/K+-ATPase and NHE3 activities and increases nitric oxide and ANP activities in the kidney.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1440-1681.2002.03697.x
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    Paper (German National Licenses)
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