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  • 1
    Electronic Resource
    Electronic Resource
    Effects of various hypoglycaemic sulphonylureas on the cardiotoxicity of glycosides (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 367-370 
    Details
    ISSN: 1432-1041
    Keywords: cardiotoxicity ; glycosides ; sulphonylureas ; digitalis intoxication ; arrhythmias ; diabetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In diabetic patients it has been shown that tolbutamide and carbutamide enhanced and glibenclamide did not influence the incidence of digitalis intoxication, or that of multifocal ectopic beats or coupling due to premature ectopic ventricular beats during digitalis therapy. In rabbits glibenclamide decreased and tolbutamide and carbutamide increased strophanthidin toxicity in a dose dependent manner. It was concluded that glibenclamide should be preferred to tolbutamide or carbutamide in digitalistreated diabetics, when satisfactorily metabolic control is not achieved with a dietary regime alone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544351
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Effect of acute hypoxia on cardiac function in alloxan-diabetic dogs (1986)
    Springer
    Basic research in cardiology 81 (1986), S. 92-100 
    Details
    ISSN: 1435-1803
    Keywords: alloxan-diabetic dog ; carbon monoxide intoxication ; ventricular diastolic stiffness ; myocardial oedema ; catecholaminaemia ; cardiac performance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The aim of the present study was to examine the left ventricular and haemodynamic parameters during acute hypoxia induced by carbon monoxide intoxication and/or after norepinephrinc administration in metabolically healthy and alloxan-diabetic dogs. In metabolically healthy animals after carbon monoxide intoxication followed by norepinephrine administration myocardial oedema occurred with a concomitant elevation of diastolic stiffness in the left ventricular wall, resulting in impaired cardiac performance. In the alloxan-diabetic animals no myocardial oedema developed and therefore no further increase of the originally elevated left ventricular diastolic stiffness could be observed. Close correlations were demonstrable between the enhanced water content and diastolic stiffness of the left ventricular wall in metabolically healthy animals as well as between the myocardial contractile force and cardiac output index in both control and diabetic dogs. In contrast to the controls, following norepinephrine administration per se decrease of cardiac performance could be observed in the alloxan-diabetic animals. Based on these results, it can be concluded that an increase of left ventricular diastolic stiffness impairs the cardiac performance in acute hypoxia following norepinephrine administration both in control and in diabetic animals, even if different reasons are responsible for it.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01907431
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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