ISSN:
1432-1041
Keywords:
cardiotoxicity
;
glycosides
;
sulphonylureas
;
digitalis intoxication
;
arrhythmias
;
diabetics
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary In diabetic patients it has been shown that tolbutamide and carbutamide enhanced and glibenclamide did not influence the incidence of digitalis intoxication, or that of multifocal ectopic beats or coupling due to premature ectopic ventricular beats during digitalis therapy. In rabbits glibenclamide decreased and tolbutamide and carbutamide increased strophanthidin toxicity in a dose dependent manner. It was concluded that glibenclamide should be preferred to tolbutamide or carbutamide in digitalistreated diabetics, when satisfactorily metabolic control is not achieved with a dietary regime alone.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00544351
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