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  • 1
    Electronic Resource
    Electronic Resource
    Serum total IgE levels in a representative sample of a Greek population (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 48 (1993), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The distribution of IgE in a large randomly stratified Greek population sample was determined in 1187 subjects (793 men and 394 women) aged between 20 and 60 years. Skin prick testing was performed and serum total IgE expressed in iu/ml was measured by Phadebas PRIST: the data are presented as the geometric mean. Subjects were classified as atopic (257 men, 118 women) and nonatopic (536 men, 276 women) according to the results of skin testing with various aeroallergens. At any age, atopic males (120.5 vs 38 iu/ml) and females (99.8 vs 29.3 iu/ml) had higher mean IgE levels, as compared to nonatopic subjects (P〈0.0001). In our adult nonatopic sample, IgE levels did not differ with age (P〉0.05). At any age, nonatopic males had higher (38 iu/ml) mean IgE levels than nonatopic females (29.3 iu/ml) (P〈0.05). The comparison of normal IgE values (nonatopic subjects) from this study with those reported by other investigators revealed that Greek adult males and females had higher IgE levels than populations from other nations. Our results represent the first report on reference values regarding serum total IgE in Greek adults.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1993.tb00703.x
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  • 2
    Electronic Resource
    Electronic Resource
    Erratum to “Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis” (1999)
    [s.l.] : Nature America Inc.
    Nature medicine 5 (1999), S. 1087-1087 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Nature Med. 5, 828– 831 (1999). On page 829, the legend for Fig 1 was incorrect. The corrected figure and legend are shown here. We regret this ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/12532
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of NGF antibodies on mast cell distribution, histamine and substance P levels in the knee joint of TNF-arthritic transgenic mice (1995)
    Springer
    Rheumatology international 14 (1995), S. 249-252 
    Details
    ISSN: 1437-160X
    Keywords: Transgenic mouse ; Nerve growth factor NGF antibodies ; Tumour necrosis factor ; Mast cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have previously shown an increase in nerve growth factor (NGF) levels and in mast cell (MC) distribution in the synovium of patients affected by rheumatoid arthritis. We now report that purified NGF antibodies injected into arthritic transgenic mice carrying the human tumour necrosis factor-α (TNF-α) gene caused reduction in the number of MCs, as well as a decrease in histamine and substance P levels within the synovium. These observations suggest that NGF antibody might be useful in studying the role of these pro-inflammtory markers in joint arthritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00262091
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  • 4
    Electronic Resource
    Electronic Resource
    Wirkung von Acetylsalicylsäure und einem Pyrido-pyrimidin-Derivat auf die Abstoßung allotransplantierter Nieren im Tierexperiment (1975)
    Springer
    Research in experimental medicine 165 (1975), S. 67-73 
    Details
    ISSN: 1433-8580
    Keywords: Renal transplantation ; Graft rejection ; Platelet thrombi ; Antiaggregating drugs ; Nierentransplantation ; Transplantatabstoßung ; Thrombocytenthromben ; Thrombocytenaggregationshemmende Pharmaka
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Thrombocytenaggregationshemmende Pharmaka — Acetylsalicylsäure und 2-Piperazinyl-4-thiomorpholino-pyrido(3,2-d)-pyrimidin-Sulfattrihydrat—werden in ihrer Wirkung auf Abstoßungsreaktionen bei allotransplantierten Nieren an Hunden untersucht. Klinisch findet sich keine Wirksamkeit der Medikamente, dagegen zeigen interessanterweise die histologischen Befunde bei der Acetylsalicylsäuregruppe eine verminderte Abstoßungsreaktion.
    Notes: Summary The effects of anti-thrombotic drugs—Acetyl-salicylic-acid and 2-Piperazinyl-4-thiomorpholino-pyrido(3,2-d)-pyrimidin-sulfat-trihydrat—on rejection reactions of renal allografts in dogs have been studied. From the clinical point of view no effectiveness of the two drugs can be found, whereas the histological findings do clearly show diminished rejection reactions in the Acetylsalicylic-acid group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01856451
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  • 5
    Electronic Resource
    Electronic Resource
    Design and synthesis of small semi-mimetic peptides with immunomodulatory activity based on Myelin Basic Protein (MBP) (1998)
    Springer
    Amino acids 14 (1998), S. 333-341 
    Details
    ISSN: 1438-2199
    Keywords: Amino acids ; Experimental allergic encephalomyelitis (EAE) ; Myelin basic protein (MBP) ; Semi-mimetic peptides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Experimental allergic encephalomyelitis (EAE) is induced in susceptible animals by immunodominant determinants of myelin basic protein (MBP). Analogs of these disease-associated peptides have been identified with disease progression upon coimmunization. Usage of peptides, with disease-specific immunomodulatory capacity in vivo is limited, however, due to their sensitivity to proteolytic enzymes. Alternative approaches include the development of mimetic molecules which maintain the biological function of an original peptide, yet are stable and able to elicit their response in pharmacological quantities. A novel technique was employed to design a series of semi-mimetic peptides, based on the guinea pig MBP72–85 peptide used to induce EAE in Lewis rats. We used isonipecotic (iNip) and aminocaproic (Acp) acids as templates. Acp-MBP72–85 peptide derived analogues were effective in inducing EAE compared to iNip-peptide analogues which were ineffective at 350μg. These findings suggest that the design and synthesis of semi-mimetic peptide molecules with immunomodulatory potential is possible and that eventually these molecules may form the basis for the development of novel and more effective disease-specific therapeutic agents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01318852
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    Paper (German National Licenses)
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