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  • 1
    Electronic Resource
    Electronic Resource
    NGF effects on hot plate behaviors in mice
    Amsterdam : Elsevier
    Pharmacology, Biochemistry and Behavior 49 (1994), S. 701-705 
    Details
    ISSN: 0091-3057
    Keywords: Behavior ; Hot plate ; Hyperalgesia ; Mouse ; Nerve growth factor ; Pain
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0091-3057(94)90090-6
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  • 2
    Electronic Resource
    Electronic Resource
    The pro-fibrogenic effect of nerve growth factor on conjunctival fibroblasts is mediated by transforming growth factor-β (2005)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 35 (2005), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Nerve growth factor (NGF) and nerve growth factor receptor (NGFR) expressions have been found to be increased in sub-conjunctival scarring.Objective The aim of this study was to investigate the in vitro effects of NGF on some pro-fibrogenic properties of human conjunctival fibroblasts.Methods Expression of NGF, trkANGFR and p75NTR on human fibroblasts grown from conjunctival biopsies and incubated for 2 or 6 days with NGF were evaluated by immunofluorescence, RT-PCR, flow cytometry and ELISA. The fibrogenic effect of NGF on conjunctival fibroblasts was investigated by evaluating their migration (wound model), proliferation ([3H]-thymidine incorporation), collagen production (3H]-proline incorporation), expression of alpha-smooth muscle actin (α-SMA) (cell surface ELISA) and contraction of 3D collagen gels.Results NGF induced the expression of p75NTR in the fibroblasts that constitutively expressed only trkANGF and increased the migration of wounded fibroblasts, but not their proliferation and collagen production. NGF induced the conversion of fibroblasts into myofibroblasts expressing α-SMA, and enhanced their contraction of a collagen matrix. Interestingly, chronic NGF treatment induced transforming growth factor-β1 (TGF-β1) production by fibroblasts, and following specific TGF-β neutralization, all the NGF-induced effects were completely abrogated.Conclusion Our findings indicate that NGF, via TGF-β induction, is likely to be involved in the healing or fibrotic processes occurring in conjunctiva during some pathological conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.2005.02241.x
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  • 3
    Electronic Resource
    Electronic Resource
    Comparative studies on testosterone and l-thyroxine effects on the synthesis of nerve growth factor in mouse submaxillary salivary glands
    Amsterdam : Elsevier
    Experimental Cell Research 125 (1980), S. 15-22 
    Details
    ISSN: 0014-4827
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0014-4827(80)90183-4
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  • 4
    Electronic Resource
    Electronic Resource
    The nerve growth factor - Established findings and controversial aspects
    Amsterdam : Elsevier
    Experimental Cell Research 154 (1984), S. 1-9 
    Details
    ISSN: 0014-4827
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0014-4827(84)90663-3
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  • 5
    Electronic Resource
    Electronic Resource
    The submaxillary salivary glands of the African rodent Praomys (mastomys) natalensis as the richest available source of the nerve growth factor
    Amsterdam : Elsevier
    Experimental Cell Research 133 (1981), S. 475-480 
    Details
    ISSN: 0014-4827
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0014-4827(81)90345-1
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of Exercise on Ovarian Morphology and Expression of Nerve Growth Factor and α1- and β2-Adrenergic Receptors in Rats with Steroid-Induced Polycystic Ovaries (2005)
    Oxford, UK : Blackwell Science Ltd
    Journal of neuroendocrinology 17 (2005), S. 0 
    Details
    ISSN: 1365-2826
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Oestadiol valerate (EV)-induced polycystic ovaries (PCO) in rats cause anovulation and cystic ovarian morphology. Denervation of ovarian sympathetic nerves restores ovulatory disruption. In the present study, we determined whether 5 weeks of voluntary exercise influence ovarian morphology and the expression of sympathetic markers in the EV-induced PCO rat model. The effect of exercise on (i) ovarian morphology; (ii) mRNA and protein expression of nerve growth factor (NGF); and (iii) mRNA and number of ovarian-expressing cells for the NGF receptor (p75 neurotrophin receptor) and the α1a-, α1b-, α1d- and β2-adrenergic receptors (ARs) in rats with EV-induced PCO was evaluated. PCO was induced by a single i.m. injection of EV, and controls were injected with oil alone in adult cycling rats. The rats were divided into four groups: (i) control (oil); (ii) exercise group (oil + exercise); (iii) a PCO group (EV); and (iv) a PCO exercise group (EV + exercise). The exercise and PCO exercise groups ran voluntarily for 5 weeks in computer-monitored wheels placed in the cages where they were housed. The results obtained indicated that ovarian morphology was almost normalised in the PCO exercise group; NGF mRNA and protein concentrations were normalised in the PCO exercise group; high numbers of NGF receptor expressing cells in PCO ovaries were lowered by exercise; and the number of immunopositive cells of the different AR subtypes were all reduced after exercise in the PCO group, except for the α1b- and β2-AR whereas the mRNA levels were unaffected, indicating transcriptional regulation. In conclusion, our data indicate a beneficial effect of regular exercise, as a modulator of ovarian sympathetic innervation, in the prevention and treatment of human PCOS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2826.2005.01378.x
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  • 7
    Electronic Resource
    Electronic Resource
    Nerve growth factor and asthma (2002)
    Oxford, UK : Blackwell Science, Ltd
    Allergy 57 (2002), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: An increasing body of evidence shows that nerve growth factor (NGF) exerts biological activity not only on the central and peripheral nervous system, but also on the immune system thereby influencing allergic diseases and asthma.(1) NGF circulating levels are increased in patients with allergic diseases and asthma, and are related to the severity of the inflammatory process and disease. In vernal keratoconjunctivitis, NGF plasma levels correlate with the number of mast cells infiltrating the conjunctiva, and NGF mRNA is increased in nasal mucosal scrapings of patients with allergic rhinitis who have high levels of NGF in serum and nasal fluids; NGF is further increased in nasal fluids after specific allergen challenge.(2) NGF is produced and released by several modulatory and effector cells of allergic inflammation and asthma, for example T-helper 2 lymphocytes, mast cells and eosinophils.(3) NGF receptors are expressed on the conjunctival epithelium of patients with allergic conjunctivitis and the number of NGF-receptor positive cells is increased in the conjunctiva of these patients. Indeed, local administration of NGF induces fibroblast activation and healing processes of human corneal ulcers, which suggests that NGF plays a role in tissue remodelling processes occurring in asthma.(4) NGF increases airway hyperreactivity to histamine in an animal model of asthma, while anti-NGF treatment reduces airway hyperreactivity induced by ovalbumin topical challenge in the sensitized mouse.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.57.s72.3.x
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  • 8
    Electronic Resource
    Electronic Resource
    The expanding role of nerve growth factor: from neurotrophic activity to immunologic diseases (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 52 (1997), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Numerous studies published in the last 10–15 years have shown that nerve growth factor (NGF), a polypeptide originally discovered in connection with its neurotrophic activity, also acts on cells of the immune system. NGF has been found in various immune organs including the spleen, lymph nodes, and thymus, and cells such as mast cells, eosinophils, and B and T cells. The circulating levels of NGF increase in inflammatory responses, in various autoimmune diseases, in parasitic infections, and in allergic diseases. Stress-related events both in animal models and in man also result in an increase of NGF, suggesting that this molecule is involved in neuroendocrine functions. The rapid release of NGF is part of an alerting signal in response to either psychologically stressful or anxiogenic conditions in response to homeostatic alteration. Thus, the inflammation and stress-induced increase in NGF might alone or in association with other biologic mediators induce the activation of immune cells during immunologic insults. A clearer understanding of the role of NGF in these events may be useful to identify the mechanisms implicated in certain neuroimmune and immune dysfunctions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1997.tb01247.x
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  • 9
    Electronic Resource
    Electronic Resource
    Role of nerve growth factor in nerve cells/skin cells physio-pathology (2004)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Experimental dermatology 13 (2004), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Studies carried out in our laboratory showed that NGF has a primary role in wound healing, induces healing in the skin of farm animals and promotes healing of human pressure ulcers. More recently, it has been demonstrated that NGF has a role in eye physiology and promotes healing of corneal ulcers in humans. In the present study, we evaluated the efficacy of topical NGF treatment in a dog model of eye chronic disease to promote epithelial healing, reduction of corneal scarring, increase sensory innervation and goblet cells density. English Bulldogs who had undergone the surgical removal of the lachrymal gland developed chronic keratoconjunctivitis sicca. One eye of each dog was treated twice daily with 100 ml of NGF ointment for 1 month, while the fellow eye was used as control. Eyes were evaluated at baseline and after 1 month of NGF. NGF treatment significantly recovered epithelial keratopathy, reduced corneal haze, improved corneal sensitivity and strongly increased the tear production as well as the conjunctival goblet cell density. This study shows that topical application of NGF improves ocular surface signs in dogs with dry eye. Overall, our findings suggest a crucial role of NGF in nerve cells/skin cells physiopathology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0906-6705.2004.0212ca.x
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  • 10
    Electronic Resource
    Electronic Resource
    Somatic and behavioural postnatal effects of fetal injections of nerve growth factor antibodies in the rat (1981)
    [s.l.] : Nature Publishing Group
    Nature 291 (1981), S. 413-415 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] 2.5 NGF was purified by the method of Bocchini and Angeletti7. After two successive carboxymethyl cellulose chromatographies, NGF was run in SDS-polyacrylamide gel electrophoresis and the corresponding band cut out, eluted from the gel matrix, mixed with complete Freund's adjuvant and injected into ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/291413a0
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