ISSN:
1420-9071
Keywords:
Vasopressin antagonists
;
V1-antagonists
;
V2-antagonists
;
neurohypophysial hormones
;
arginine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Substitution of arginine for glutamine in the 4-position of a vasopressin V1 antagonist has been reported to turn it into an agonist. We resynthesized this 4-arginine analog and synthesized additional cyclic and linear vasopressin antagonists containing a 4-arginine. The presence of a 4-arginine in the resynthesized and new analogs had relatively minor effects on their antivasopressin V1 and V2 antagonistic potencies.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02041261
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