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  • 1
    Electronic Resource
    Electronic Resource
    Consensus use of desmopressin and antifibrinolytics in three university clinics (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 53 (1998), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.1998.tb15160.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Garlic study vindicated by official investigation (2000)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 404 (2000), S. 542-542 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Sir Your News story “German garlic study under scrutiny” reports allegations of data manipulation and incorrect data analysis raised in a German newspaper about a study we carried out using a garlic preparation called Kwai. They were made after the results of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35007247
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of garlic coated tablets in peripheral arterial occlusive disease (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 383-386 
    Details
    ISSN: 1432-1440
    Keywords: Peripheral arterial occlusive disease ; Garlic powder ; Kwai® ; Sapec®
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary For the first time, a weak clinical efficacy of a 12-week therapy with garlic powder (daily dose, 800 mg) is demonstrated in patients with peripheral arterial occlusive disease stage II. The increase in walking distance in the verum group by 46 m (from 161.0 ± 65.1 to 207.1 ± 85.0 m) was significantly higher (P〈0.05) than in the placebo group (by 31 m, from 172.0 ± 60.9 to 203.1 ± 72.8). Both groups received physical therapy twice a week. The diastolic blood pressure, spontaneous thrombocyte aggregation, plasma viscosity, and cholesterol concentration also decreased significantly. Body weight was maintained. It is quite interesting that the garlic-specific increase in walking distance did not appear to occur until the 5th week of treatment, connected with a simultaneous decrease in spontaneous thrombocyte aggregation. Therefore, garlic may be an appropriate agent especially for the long-term treatment of an incipient intermittent claudication.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00186628
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of garlic on platelet aggregation in patients with increased risk of juvenile ischaemic attack (1993)
    Springer
    European journal of clinical pharmacology 45 (1993), S. 333-336 
    Details
    ISSN: 1432-1041
    Keywords: Garlic ; Platelet aggregation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A platelet-inhibiting effect is described for garlic. In this double-blind, placebo-controlled study on 60 voluntary subjects with cerebrovascular risk factors and constantly increased platelet aggregation it was demonstrated that the daily ingestion of 800 mg of powdered garlic (in the form of coated tablets) over 4 weeks led to a significant inhibition of the pathologically increased ratio of circulating platelet aggregates and of spontaneous platelet aggregation. The ratio of circulating platelet aggregates decreased by 10.3%, from 1.17±0.08 to 1.05±0.11 (P〈0.01), and spontaneous platelet aggregation by 56.3%, from 40.7±23.3 to 17.8±23.2 degrees (P〈0.01) during the garlic phase. There were no significant changes in the placebo group. The parallel group comparison (garlic versus placebo) revealed a significantly different ratio of circulating platelet aggregates after 4 weeks of treatment (P〈0.05). After the 4-week wash-out phase the values increased again to 1.19±0.32 and 34.9±28.7°, reaching the initial values (run-in phase prior to the ingestion of garlic). Since garlic is well tolerated it would be worth testing it in a controlled clinical trial for usefulness in preventing disease manifestations associated with platelet aggregation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265950
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Increased rate of factor V Leiden mutation in patients with cerebral venous thrombosis (1998)
    Springer
    Journal of neurology 245 (1998), S. 149-152 
    Details
    ISSN: 1432-1459
    Keywords: Key words Activated protein C ; resistance ; Thrombophilia ; Coagulation system ; Stroke
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated the association between cerebral venous thrombosis and hereditary resistance to activated protein C (APC) in 12 consecutive German patients with non-fatal cerebral venous thrombosis and in 187 controls without a history of thrombotic disorder. Three patients (25%) had a mutation in the factor V Leiden gene against only one subject in the control group. This difference was significant (P〈0.05), with an odds ratio of 11.7 (1.5–87 ; 95% confidence interval). Two patients carrying the mutation had additional common risk factors for thrombosis, and 2 had a positive family history of thromboembolism. We conclude that inherited APC resistance by a mutation in factor V Leiden is an important risk factor in non-fatal cerebral venous thrombosis. We recommend testing for APC resistance and, if abnormal for factor V Leiden mutation in patients with cerebral venous thrombosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050195
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Diagnostik und Therapie der hämorrhagischen Diathese in der perioperativen Situation (1999)
    Springer
    Gefässchirurgie 4 (1999), S. 5-12 
    Details
    ISSN: 1434-3932
    Keywords: Schlüsselwörter Blutungsneigung ; Hämorrhagische Diathese ; Erworbene und angeborene Thrombopathien ; Plasmatische Gerinnungstörungen ; DDAVP ; Key words Bleeding tendency ; Hemorrhagic diathesis ; Acquired and congenital qualitative platelet disorders ; Blood coagulation disorders ; Deamino-d-arginine vasopressin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract In surgical procedures associated with high blood loss, such as vascular and cardiac operations, differential diagnosis and therapy of perioperative hemorrhage are of special importance. Preoperative screening for patients at high risk of bleeding and in particular for those with qualitative platelet disorders [drug-induced platelet disorders (in particular ASS), von Willebrand's disease and other congenital platelet disorders] is effective in minimizing blood loss. Bleeding in acute medical emergencies or during emergency operations may require treatment without specific investigations being performed in advance. Therefore, simple schemes are essential for the rapid management of acute hemostatic problems. The aim of this paper was to address the diagnostic and therapy of hemorrhagic diathesis focusing mainly on diagnosis and therapy of hemorrhagic diathesis due to blood platelet disorders and blood coagulation disorders and preoperative identification of patients at increased risk of bleeding.
    Notes: Zusammenfassung Die Differentialdiagnostik und Therapie von perioperativen Blutungen besitzt in der Gefäß- und Kardiochirurgie bei Eingriffen mit hohen Blutverlusten einen besonderen Stellenwert. So ist es sinnvoll, Patienten mit einem erhöhten Blutungsrisiko bereits präoperativ zu erfassen und adäquat vorzubereiten. Insbesondere die präoperative Erfassung von Thrombopathien [medikamenteninduzierte Thrombopathien (insbesondere durch ASS), von-Willebrand-Jürgens-Syndrom, andere angeborene Thrombopathien] ist bei der Minimierung von Blutverlusten effektiv. Nicht elektive Situationen (Blutung bei Notoperationen, Akutpatienten) müssen oft ohne gezielte hämostaseologische Diagnostik rational therapiert werden. Einfache Schemata sind für ein schnelles Handeln unabdingbar. In dieser Arbeit soll versucht werden, Hinweise zu Diagnostik und Therapie der hämorrhagischen Diathese mit den Schwerpunkten: Diagnostik und Therapie der thrombozytär bedingten hämorrhagischen Diathese und Diagnostik und Therapie der plasmatisch bedingten hämorrhagischen Diathese aus hämostaseologisch-transfusionsmedizinischer Sicht zu vermitteln. Ein für den Routinebetrieb auf chirurgischen Stationen anwendbares Schema zur präoperativen Erfassung von Patienten mit erhöhtem Blutungsrisiko sowie erste Erfahrungen damit werden vorgestellt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00010539
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    Paper (German National Licenses)
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