ISSN:
1573-3017
Keywords:
Mutagens
;
Ames test
;
cytochrome P-450
;
detoxification enzymes
;
metabolic activation
;
aquatic ecosystems
Source:
Springer Online Journal Archives 1860-2000
Topics:
Energy, Environment Protection, Nuclear Power Engineering
Notes:
Abstract Extracts from tissues of a wide range of aquatic organisms (plants, plankton, decapods, molluscs, fish, Baikal seals, and fish-eating birds and their eggs) from Lake Baikal and from the Selenga River estuary and tissue extracts of birds breeding on Hornoya Island (northern Norway) were assayed for mutagenicity using the Ames Salmonella/microsome test. The activities of cytochrome P-450 and the enzymes of phase II of detoxification were also studied in the liver of fish and birds. Evidence was found for the accumulation of mutagens in the food chain. The relationship of bioaccumulation to the levels of enzyme activities possessing both detoxification and activation functions is discussed in the cases of fish and birds. The accumulation of mutagens was found to depend on the activity and the level of induction of the enzymes providing the detoxification and metabolic activation in the livers of fish and birds.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008962601914
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