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  • 1
    Electronic Resource
    Electronic Resource
    The value of needle biopsy in the diagnosis of musculoskeletal tumors (1996)
    Springer
    International journal of clinical oncology 1 (1996), S. 35-38 
    Details
    ISSN: 1437-7772
    Keywords: musculoskeletal tumors ; needle biopsy ; diagnosis ; accuracy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background Percutaneous needle biopsy has many advantages over open biopsy in the treatment of neoplasms. However, the accuracy of the needle biopsy in the diagnosis of musculoskeletal tumors has not been established. It is essential to evaluate the accuracy and limitations of the procedure in musculoskeletal tumors. Methods The diagnoses from 66 needle biopsies (bone, 37; soft tissue, 29) performed on 64 consecutive patients using a jamshidi needle (bone tumors) or a Tru-cut needle (soft tissue tumors) were compared with the final diagnoses made by open biopsy and/or a definitive operation. Results Fifty-eight specimens (87.9%) were judged to be adequate for histological examination. It was technically difficult to obtain undamaged cores from very hard bony lesions or sclerotic cyst walls. A pathologist with experience in musculoskeletal tumors was able to differentiate malignant tumors from benign lesions in 98.3% of the cases (bone, 100%; soft tissue, 96.4%) and arrive at a specific diagnosis in 91.4% (bone, 100%; soft tissue, 82.1%) when adequate cores were obtained. It was troublesome to distinguish a well-differentiated liposarcoma from a benign lipoma, or inflammatory lesions from benign tumorous conditions. The overall accuracy for needle biopsy was 80.3% (bone, 81.1%; soft tissue, 79.3%). There was no morbidity related to the procedure. Conclusion The results indicate that meedle biopsy is a safe and accurate technique for diagnosing musculoskeletal tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02347266
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  • 2
    Electronic Resource
    Electronic Resource
    Evaluation of soft tissue sarcomas response to preoperative treatment: Assessment by angiography, thallium scintigraphy, and dynamic MRI (1996)
    Springer
    International journal of clinical oncology 1 (1996), S. 93-99 
    Details
    ISSN: 1437-7772
    Keywords: soft tissue sarcoma ; preoperative treatment ; histologic effect ; angiography ; thallium scintigraphy ; dynamic MRI
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background Assessment of the response of soft tissue sarcomas to preoperative treatment is of significant clinical importance. However, there are few reports concerning the accuracy of each imaging technique in assessing the response of soft tissue sarcomas to preoperative treatment. Methods The responses of 15 soft tissue sarcomas to preoperative treatment by digital subtraction angiography, thallium scintigraphy, and dynamic magnetic resonance imaging (MRI) were compared with histologic evaluation of the resected specimens. Tumors with at least 90% histologic necrosis were considered to be effectively treated. Results The accuracy of each assessment technique was 58.3% for digital subtraction angiography, 80% for thallium scintigraphy, and 77.8% for dynamic MRI. Both the differences in slope before and after treatment and the posttreatment slope values of dynamic MRI correlated with the histologic responses. Conclusion Thallium scintigraphy and dynamic MRI showed sufficient value in the assessment of soft tissue sarcomas responses to preoperative treatment. Dynamic MRI had major advantages in its quantitative and spatial resolutions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02348274
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of dose intensity of methotrexate, doxorubicin, and ifosfamide on the prognosis of patients with osteosarcoma (1999)
    Springer
    International journal of clinical oncology 4 (1999), S. 36-40 
    Details
    ISSN: 1437-7772
    Keywords: Key words Osteosarcoma ; Chemotherapy ; Dose inten-sity ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. The prognosis of patients with osteosarcoma has improved due to the introduction of systemic chemotherapy. The current study tried to identify the effect of each anti-tumor drug on the prognosis of patients with osteosarcoma. Methods. The records of 29 patients with osteosarcoma who received systemic chemotherapy were retrospectively analyzed. All tumors were classified as stage IIB (Enneking's surgical stage) and were located around the knee joint or more distal areas. The histologic response to preoperative chemotherapy was determined in 20 patients: 9 patients had grade 1, 4 grade 2, 5 grade 3, and 2 grade 4. The mean follow-up period was 102 months. Results. The 5-year overall survival and relapse-free survival (RFS) in the 29 patients was 47.7% and 41.4%, respectively. The 5-year RFS for the 7 good responders (grade 3 and 4) was 85.7%, and that for the 13 poor responders (grade 1 and 2) was 23.1% (P = 0.008). The mean preoperative dose intensity (DI) of methotrexate (MTX) for good responders was significantly higher than that for poor responders (P = 0.028). In 23 patients who received MTX and doxorubicin (ADR) but not ifosfamide (IFOS), the DI of MTX significantly influenced the RFS (P = 0.0128). In the 13 poor responders, 6 of whom received IFOS, the DI of IFOS and ADR significantly influenced RFS (P = 0.0112, 0.0395). Conclusion. The preoperative DI of MTX was related to the histologic response rate. The DI of MTX was significartly associated with the patients' RFS. In poor responders, the DI of IFOS and ADR influenced the patients' RFS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101470050021
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  • 4
    Electronic Resource
    Electronic Resource
    Giant schwannoma of the back (2000)
    Springer
    Archives of orthopaedic and trauma surgery 120 (2000), S. 467-469 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We treated a patient with giant schwannoma of the back. The tumor measured 35 × 25 × 12 cm and weighted 1840 g. Histological diagnosis was benign schwannoma. To our knowledge, there is no previous report of such a large schwannoma of the back.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004029900081
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  • 5
    Electronic Resource
    Electronic Resource
    Preoperative hyperthermochemoradiotherapy for soft tissue sarcoma (1996)
    Springer
    Journal of orthopaedic science 1 (1996), S. 246-251 
    Details
    ISSN: 1436-2023
    Keywords: hyperthermia ; radiation therapy ; chemotherapy ; soft tissue sarcoma ; histologic effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated the efficacy of preoperative hyperthermia combined with radiation therapy and systemic chemotherapy (hyperthermochemoradiotherapy; HCRT) as a multimodality limb-sparing approach for soft tissue sarcomas. From January 1991 to December 1994, HCRT was performed in 13 patients with soft tissue sarcomas at our institute. Hyperthermia, with an intratumoral temperature of ≥42.0°C, was given for 1 h for a total of eight to ten times. Radiation therapy (30–40 Gy) was given at 200 cGy per fraction. Two cycles of chemotherapy were given before surgery. It took 4–5 weeks to accomplish the HCRT, and surgery was performed 3 weeks later. Partial response (PR) was achieved in 3 patients and no change (NC) was shown in 10. The mean reduction of tumor volume was 20.2%. Pathological examination of the resected specimen revealed 10%–100% tumor necrosis (mean 76.4%). There was no correlation between histologic response and reduction of tumor volume. Limb-sparing surgery was feasible in 12 patients (92.3%) and the final limb salvage rate was 84.6%. No local recurrence was observed during a mean follow-up time of 25 months. Four patients developed distant metastases and 2 patients died of the disease. The results of this study indicate that HCRT is an effective treatment for limb-threatening soft tissue sarcomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02348783
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  • 6
    Electronic Resource
    Electronic Resource
    Vancomycin-Impregnated polymethylmethacrylate beads for methicillin-resistant Staphylococcus aureus (MRSA) infection: Report of two cases (1998)
    Springer
    Journal of orthopaedic science 3 (1998), S. 163-168 
    Details
    ISSN: 1436-2023
    Keywords: Key words: vancomycin ; polymethylmethacrylate (PMMA) ; beads ; methicillin-resistant Staphylococcus aureus (MRSA) ; infection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Two patients with methicillin-resistant Staphylococcus aureus (MRSA) infection were treated with vancomycin (VCM)-impregnated polymethylmethacrylate (PMMA) beads. One patient, who had a history of polycystic kidney and diabetes mellitus, who was receiving hemodialysis due because of non-functional kidney, underwent resection of an intermediate grade chondrosarcoma in the pelvis. MRSA infection developed and curettage of the lesion was performed, but MRSA infection recurred. During the second revision surgery, VCM-impregnated PMMA beads were implanted. MRSA infection has not recurred for 16 months since the implantation of the VCM beads. The second patient had a history of total hip arthroplasty (THA) performed because of coxarthrosis. After the initial surgery, MRSA infection developed, recurring after the second revision surgery for THA. After curettage following removal of the prosthesis, VCM beads were implanted with a spacer composed of VCM-PMMA and a Luque rod. Infection did not recur and THA revision was performed 3 months after the VCM beads implantation. Fifteen months after the last revision surgery, infection has not recurred.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007760050037
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  • 7
    Electronic Resource
    Electronic Resource
    Value of thallium-201 scintigraphy in bone and soft tissue tumors (1998)
    Springer
    Journal of orthopaedic science 3 (1998), S. 297-303 
    Details
    ISSN: 1436-2023
    Keywords: Key words:201Tl-scintigraphy ; bone and soft tissue tumor ; preoperative chemotherapy ; histologic effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: The potential role of thallium-201 (201Tl) scintigraphy in the imaging of various musculoskeletal tumors was investigated in 80 patients. Uptake of 201Tl was observed in 17 (100%) malignant bone tumors, 6 (100%) giant cell tumors, and 2 of 8 (25%) benign bone tumors. Nineteen of 30 malignant soft tissue tumors (63%) were positive for 201Tl scintigraphy, while 2 of 14 benign soft tissue tumors (14%) yielded positive results. None of 6 liposarcomas were visualized by 201Tl scintigraphy. There was no 201Tl uptake in the tissues of 5 non-tumorous conditions. Ten patients with osteosarcoma were evaluated by 201Tl scintigraphy both pre- and post-chemotherapy. There was a significant correlation between changes in tumor-to-normal count ratio and percent necrosis of the resected tumor. The mean decrease in tumor-to-normal count ratio was 71% for patients with ≥90% tumor necrosis and 26% for those with 〈90% tumor necrosis. Serial 201Tl scintigraphy, with quantitative analysis of alterations in 201Tl uptake, may provide a quantitative and objective measure of the effect of preoperative chemotherapy in patients with malignant bone tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007760050056
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