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  • 1
    Electronic Resource
    Electronic Resource
    Absence of interaction between tenoxicam and warfarin (1992)
    Springer
    European journal of clinical pharmacology 42 (1992), S. 227-229 
    Details
    ISSN: 1432-1041
    Keywords: Tenoxicam ; Warfarin ; drug interaction ; pharmacokinetics ; anticoagulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The influence of tenoxicam on plasma warfarin concentrations and on its anticoagulant effect has been studied in healthy volunteers. Tenoxicam did not alter the plasma warfarin concentration versus time profile. Treatment with it for 14 days had no effect on the average dose of warfarin required to maintain the prothrombin time within a specified range. The coumarin dose index, an indicator of warfarin sensitivity, remained unchanged during tenoxicam administration. The results demonstrate the lack of a clinically relevant effect of tenoxicam on warfarin-induced anticoagulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00278491
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  • 2
    Electronic Resource
    Electronic Resource
    Coincidence of acquired factor-X deficiency and disseminated intravascular coagulation in patients with acute nonlymphoblastic leukemia (1991)
    Springer
    Annals of hematology 62 (1991), S. 174-179 
    Details
    ISSN: 1432-0584
    Keywords: Factor-X deficiency ; Coagulation factors ; Acute leukemia ; Disseminated intravascular coagulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Systematic clotting studies were performed in 157 patients with de novo acute nonlymphoblastic leukemia (ANLL) prior to treatment. Sixteen patients had disseminated intravascular coagulation (DIC). Three of the patients with DIC (two with M3, one with M5 leukemia) had a marked isolated factor-X deficiency (factor X∶C 21%, 33%, and 41%, respectively). Another four patients had a mild isolated factor-X deficiency (factor X∶C 55%–68%). In these seven patients the remaining liver-synthesized clotting factors (factors II, VII, IX, V) as well as serum albumin and cholinesterase were within the normal range. Liver disease or vitamin-K deficiency could therefore be excluded. In none of the 141 patients without DIC was a marked isolated factor X deficiency observed; two patients had moderately reduced factor X∶C levels but normal liver-synthesized proteins. Induction treatment led to the control of DIC with an almost parallel increase of fibrinogen and factor X up to normal in all patients with factor-X deficiency who achieved complete remission. In one patient, recurrence of leukemia was associated with reoccurrence of DIC and marked factor-X deficiency. We conclude that there is a coincidence of isolated factor-X deficiency and DIC in some patients with ANLL. In some patients, this factor-X deficiency may be severe enough to contribute to the bleeding tendency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01703144
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  • 3
    Electronic Resource
    Electronic Resource
    Hepatic and splenic abscesses — a common complication of intensive chemotherapy of acute myeloid leukemia (AML) (1991)
    Springer
    Annals of hematology 63 (1991), S. 33-38 
    Details
    ISSN: 1432-0584
    Keywords: Hepatosplenic abscesses ; AML ; Diagnosis ; Sonography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to determine the frequency of hepatosplenic abscesses in AML patients during chemotherapy and to evaluate the clinical and laboratory characteristics of this complication we performed a prospective study over a 28-month period. Fifty-five consecutive patients with de novo AML or relapse who received intensive chemotherapy underwent regular ultrasound examinations. In 16 patients (29.1%) hepatic and/or splenic abscesses were detected sonographically. Histopathological evidence for abscess formation was obtained in five of these 16 patients. In three patients granulation tissue and in one patient necrotizing granulomas were found. Causative micro-organisms were proven in only three patients:Candida hyphae were demonstrated in one patient, gram-positive cocci in another. Bacteria and fungi were seen in the tissue specimen of the third patient. Patients with hepatosplenic abscesses had significantly prolonged fever after neutrophil recovery but did not differ from patients without abscesses in any other laboratory or clinical features. Due to the absence of specific alerting clinical and laboratory signs and symptoms of hepatosplenic abscesses, routine ultrasound examination is required for detection of this complication. The presence of hepatic and/or splenic abscesses does not necessarily worsen the prognosis, but it may influence the decision on further chemotherapy and antimicrobial treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01714958
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  • 4
    Electronic Resource
    Electronic Resource
    Cerebral sinus thrombosis in a patient with hereditary protein S deficiency: Case report and review of the literature (1992)
    Springer
    Annals of hematology 64 (1992), S. 105-109 
    Details
    ISSN: 1432-0584
    Keywords: Cerebral sinus thrombosis ; Protein S deficiency ; Thrombophilia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Hereditary protein S deficiency is an established risk factor for venous thrombosis. The common sites of thrombosis are the deep leg and pelvic veins. We report on a 38-year-old female patient with hereditary protein S deficiency and a previous history of deep leg vein thrombosis, who developed thrombosis of the cerebral straight and superior sagittal sinus while taking oral contraceptives. The diagnosis was established by computerized tomography and carotid angiography. Lysis of the thrombus occurred during heparin treatment. The hereditary nature of protein S deficiency was documented by family studies, since nine additional family members deficient in protein S were identified. Nineteen published cases of cerebral vein thrombosis and a deficiency of either antithrombin III, protein C, or protein S were reviewed. Compared with patients without a deficiency state, the clinical features of cerebral vein thrombosis were similar except for an earlier onset and a positive medical history of venous thromboembolic events in a considerable number of patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01715355
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  • 5
    Electronic Resource
    Electronic Resource
    High efficacy of the German multicenter ALL (GMALL) protocol for treatment of adult acute lymphoblastic leukemia (ALL) — a single-institution study (1994)
    Springer
    Annals of hematology 69 (1994), S. 181-188 
    Details
    ISSN: 1432-0584
    Keywords: Acute lymphoblastic leukemia Treatment ; Prognostic factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sixty-one consecutive patients with acute lymphoblastic leukemia (ALL) (B-ALL excluded) were treated with the protocol described by Hoelzer et al. [15]. The complete remission (CR) rate was 85% (52/61 patients). Three patients died during induction therapy; six patients were refractory to treatment. The median duration of continuous complete remission (CCR), disease-free survival (DFS), and overall survival was 41.5, 41.4, and 40.8 months, respectively. At 5 years the probability of CCR was 49%, of DFS 43.5%, and of overall survival 41.6%. In the univariate analysis older age (〉35 years,p=0.01), bcr-abl positivity (p=0.007), and time to CR (〉4 weeks,p=0.05) were significantly unfavorable prognostic factors. In the multivariate analysis only age (p=0.006) and time to CR (p = 0.02) remained significant. Thus, our data confirm the high efficacy of this treatment regimen with regard to CR rate and remission duration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02215951
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  • 6
    Electronic Resource
    Electronic Resource
    Granulocyte colony-stimulating factor (G-CSF) as an adjunct to induction chemotherapy of adult acute lymphoblastic leukemia (ALL) (1993)
    Springer
    Annals of hematology 66 (1993), S. 283-289 
    Details
    ISSN: 1432-0584
    Keywords: Acute lymphoblastic leukemia ; Treatment ; Granulocyte colony stimulating factor ; Febrile neutropenia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Our purpose was to evaluate the ability of re-combinant human granulocyte colony-stimulating factor (r-metHuG-CSF) as an adjunct to induction chemo-therapy of acute lymphoblastic leukemia (ALL) to ameliorate chemotherapy-induced neutropenia and thus allow patients to receive full doses of chemotherapy on time. Sixteen consecutive patients with adult ALL (13 de novo, three relapsed) were treated with induction chemo-therapy according to the BMFT protocol and received in addition r-metHuG-CSF (200μg/m2/day). Patients who were treated with the same induction chemotherapy but without G-CSF between 1982 and 1990 served as controls. Fifteen of the 16 patients achieved complete hematological remission. One patient died because of fungal septicemia. Compared with historical controls, G-CSF-treated patients had a significantly faster neutrophil recovery in phase I, resulting in neutrophil counts 〉 1000/μl at day 17 vs day 26 (in median) in controls. In phase II, the onset of severe leukocytopenia (〈 1500/μl) was significantly (p = 0.01) delayed and the degree of leukocytopenia less pronounced (mean nadir 3300/μl) in G-CSF-treated patients compared with controls (1880/μl). The number of days of febrile neutropenia was not different in phase I. In phase II it was lower in study patients (0 vs 1.1 days), but the difference did not reach statistical significance (p = 0.09). Full doses of chemo-therapy could be given on time to 11/13 (85%) G-CSF pa-tients but to only 7/30 (23%) controls. These data indicate that (a) G-CSF can be given along with chemotherapy in induction treatment of ALL without compromising efficacy; (b) the duration of neutropenia in phase I is markedly shortened and the degree of leukocytopenia in phase II ameliorated; (c) these beneficial effects allow patients to receive full doses of chemotherapy on time.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01695970
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  • 7
    Electronic Resource
    Electronic Resource
    Transient lupus anticoagulant associated with hypoprothrombinemia and Factor XII deficiency following adenovirus infection (1993)
    Springer
    Annals of hematology 67 (1993), S. 95-99 
    Details
    ISSN: 1432-0584
    Keywords: Transient lupus anticoagulant ; Adenovirus ; Factor II and XII deficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A potent lupus anticoagulant (LA) was detected in four children, 1 week after the clinical onset of an adenovirus infection. The adenovirus infection was documented by direct virus detection in the stool of one patient and serologically in the others. None of the children had elevated titers of IgM- and only one of IgG-anticardiolipin antibodies (ACA). All patients had a marked reduction of prothrombin activity as well as antigen. Prothrombin-antibody complexes were demonstrated in the patients' plasma or mixtures of patient and normal plasma. Factor XII activity was moderately reduced in three of the patients. All coagulation abnormalities returned to normal within 4–12 weeks. Localized bleeding was observed in two cases, but there was no generalized bleeding tendency or evidence of thrombosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01788133
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  • 8
    Electronic Resource
    Electronic Resource
    Duration of second complete remission in patients with acute myeloid leukemia treated with chemotherapy: a retrospective single-center study (1996)
    Springer
    Annals of hematology 72 (1996), S. 216-222 
    Details
    ISSN: 1432-0584
    Keywords: Key words Acute myeloid leukemia ; Salvage chemotherapy ; Long-term remission
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A total of 168 patients with de novo AML were retreated with chemotherapy at relapse following first CR; 66 patients (39%) achieved a second complete remission (CR). The probability of achieving a second CR was highly dependent on the duration of the first remission. Patients who received no or conventional postremission chemotherapy after second CR had a median remission duration of 7.5 months, and the probability of remaining in remission at 3 years was 24%. Patients with a first CR of more than 12 months had a median second remission duration of 18 months. The probability of a second CCR was 35% at 3 years and 24% at 5 years, whereas none of the patients with a first CR of less than 12 months was in remission at 3 years. Only a poor correlation (p=0.31) was found when the durations of the first and second CR were compared in patients with a second relapse. Patients with long-lasting remissions and long-term survivors after second CR are characterized by a first CR duration of 〉12 months and favorable or normal cytogenetics. The type of salvage treatment seems to be less important for achievment of long-term remission, but it is probably important to administer consolidation chemotherapy after second CR. Other so-far ill-defined factors may be responsible for the supression of the leukemic clone in patients with long-lasting remissions following chemotherapy for relapse after second CR.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050163
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  • 9
    Electronic Resource
    Electronic Resource
    Low-molecular-weight heparin-induced skin necrosis (1998)
    Springer
    Annals of hematology 77 (1998), S. 127-130 
    Details
    ISSN: 1432-0584
    Keywords: Key words Low-molecular-weight heparin ; Unfractionated heparin ; Skin necrosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We report a case of low-molecular-weight heparin (LMWH)-induced skin necrosis in a patient with chronic lymphatic leukemia. The patient had heparin-PF4 antibodies and the heparin-induced platelet activation (HIPA) test was positive, but platelet counts remained normal. Analysis of seven cases of LMWH-induced skin necrosis revealed that this complication occurred mostly in patients previously exposed to heparin, and that severe problems such as thrombocytopenia or thromboembolic complications were rare. This is in contrast to skin necrosis induced by unfractionated heparin (UFH), where a substantially higher number of patients suffered from thrombocytopenia and thromboembolism. In addition, most patients with UFH-induced skin necrosis were not pretreated with heparin. Therefore, it is possible that LMWH is less immunogenic than UFH and requires repeated exposure for induction of skin necrosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050427
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  • 10
    Electronic Resource
    Electronic Resource
    Plasma concentrations of free and sulfoconjugated dopamine, epinephrine, and norepinephrine in healthy infants and children (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 672-675 
    Details
    ISSN: 1432-1440
    Keywords: Plasma catecholamines ; Dopamine ; Norepinephrine ; Epinephrine ; Sulfoconjugation ; Infants ; Children
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Plasma concentrations of free and sulfoconjugated catecholamines were measured in healthy infants and children under resting conditions. Free norepinephrine and epinephrine levels were up to three times higher in healthy children under 2 years than in adults, even under true resting conditions. In contrast, free dopamine concentrations of all age groups fell within the normal range for adults. The levels of sulfoconjugation were in the adult range.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01718028
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