Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Effects of metamizol on nociceptive responses to stimulation of the ureter and on ureter motility in anaesthetised rats (1996)
    Springer
    Inflammation research 45 (1996), S. 150-154 
    Details
    ISSN: 1420-908X
    Keywords: Analgesia ; Pain ; Renal colic ; Dipyrone ; Cyclooxygenase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In this study, we have examined the effects of metamizol (dipyrone), a non-opioid analgesic which is effective in relieving renal colic pain, on nociceptive responses evoked by stimulation of the ureter, on pyeloureteral motility and on intraureter pressure after ureter obstruction in anaesthetised rats. Metamizol (5–50 mg/kg i.v.) dose-dependently inhibited reflex pressor responses evoked by distensions of the ureter to pressures of 30, 55 and 75 mmHg for 30 s (ID50=8±1 mg/kg). Metamizol also dose-dependently reduced intraureter pressure during total ureter occlusion (25 mg/kg produced a reduction of 25% in 10 min). However, metamizol at doses up to 50 mg/kg had no effect on pyleoureteric motility (contraction amplitude, rate or intraureter pressure) under normal pressure conditions. We conclude that metamizol has a direct antinociceptive action on pain of ureteric origin, and spasmolytic effects after ureter obstruction (but not under normal conditions) which may also contribute to pain relief.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02265170
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Analgesic activity of the novel COX-2 preferring NSAID, meloxicam in mono-arthritic rats: Central and peripheral components (1997)
    Springer
    Inflammation research 46 (1997), S. 203-210 
    Details
    ISSN: 1420-908X
    Keywords: Key words: Analgesia — Pain — Arthritis — Cyclooxygenase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: To study the characteristics and site of the analgesic action of meloxicam.¶Subjects: Adult female Wistar rats.¶Treatment: Monoarthritis was induced (for behavioural studies) by injection of complete Freund's adjuvant into the ankle. Meloxicam was given for 5 days (0.1–4 mg/kg/day i.p.). Inflammation of the knee or paw (for electrophysiology) was induced with carrageenan. Meloxicam was given i.v. (4–64 mg/kg).¶Methods: Rats were tested daily for joint hyperalgesia, and hindlimb posture (behaviour). At post-mortem, joint stiffness, oedema and gastric lesions were assessed. In anaesthetised rats, nociceptive reflex responses to stimulation of the paw were compared (electrophysiology). Statistics were performed using one-way analysis of variance.¶Results: Meloxicam reduced swelling and stiffness of the inflamed joint, joint hyperalgesia (ID50 = 0.4 ± 0.4 mg/kg/day) and spontaneous pain-related behaviour. It also inhibited peripherally mediated reflex responses to stimulation of inflamed tissue (ID50 = 7.6 ± 0.8 mg/kg i.v.) without affecting centrally mediated reflexes.¶Conclusions: Systemic meloxicam produces analgesia largely via peripheral mechanisms. The rapidity of its actions indicates a direct effect on sensitised nociceptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050174
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Antinociceptive activity of metamizol in rats with experimental ureteric calculosis: Central and peripheral components (1998)
    Springer
    Inflammation research 47 (1998), S. 389-395 
    Details
    ISSN: 1420-908X
    Keywords: Key words: Pain — Analgesia — Ureter — Dipyrone — Cyclooxygenase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: To study the antinociceptive effects of metamizol in a rat model of ureteric calculosis.¶Subjects: Adult female Wistar rats (n = 40).¶Treatment: Metamizol was given i.p. 50–100 mg/kg, 3 times daily for 4 days for behavioural testing, and 25–100 mg/kg i.v. whilst recording peristalsis or dorsal horn neurons.¶Methods: An artificial stone was induced in one ureter. In 3 separate groups of stone-implanted rats, behaviour was recorded continuously on video tape, ureteric peristalsis or the electrical activity of single nociceptive dorsal horn neurons with ureteric input was recorded under anaesthesia. Data were compared with analysis of variance.¶Results: Metamizol inhibited the behavioural visceral crises, the abnormal ureteric peristalsis and the activity of nociceptive dorsal horn neurons.¶Conclusions: Metamizol has central antinociceptive effects on the pain produced by a ureteric stone, and an additional spasmolytic effect on the hyperperistalsis produced by the stone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050349
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...