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  • 1
    Electronic Resource
    Electronic Resource
    Alphacalcidol in Prevention of Glucocorticoid-Induced Osteoporosis (1999)
    Springer
    Calcified tissue international 65 (1999), S. 328-331 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Osteoporosis — Corticosteroids — Alphacalcidol — Vitamin D — Fracture prevention.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. One of the major drawbacks of glucocorticoids long-term therapy is the occurrence of a severe osteoporosis characterized by fractures occurring at different sites, mainly at the level of trabecular bone. One of the major determinants of glucocorticoid-induced osteoporosis is a decrease in the intestinal absorption of calcium (Ca) leading to a secondary hyperparathyroidism. D-hormones have been shown to significantly improve Ca absorption in the gut and subsequently to decrease parathyroid hormone circulating levels, hence normalizing bone turnover. In a recent study evaluating 145 patients suffering from diseases requiring long-term treatment with high doses of corticosteroids, we have demonstrated a significant benefit of alphacalcidol (1 μg/day) over placebo in terms of changes in bone mineral density of the lumbar spine. These results are in accordance with studies showing better prevention of bone loss and vertebral fractures in cardiac transplant patients treated with alphacalcidol than those treated with etidronate. There is now a convergent body of evidence to suggest that alphacalcidol is a reasonable, safe, and effective option for the prevention of glucocorticoid-induced osteoporosis, provided that serum Ca is monitored on a regular basis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002239900706
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  • 2
    Electronic Resource
    Electronic Resource
    Thromboxane and prostacyclin release in adult respiratory distress syndrome (1987)
    Springer
    Intensive care medicine 13 (1987), S. 167-174 
    Details
    ISSN: 1432-1238
    Keywords: Adult respiratory distress syndrome ; Thromboxane B2 ; 6-keto-PGF1α ; Sepsis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Plasma thromboxane B2 (TXB2) and 6-ketoprostaglandin F1α (6-keto-PGF1α) were measured in 84 patients at risk of developing adult respiratory distress syndrome (ARDS) (44 patients following multiple trauma, 29 patients following abdominal surgery and 11 patients with acute pancreatitis). Forty-nine of these 84 patients developed an ARDS. High (〉140 pg/ml plasma) TXB2 values were found in 52/84 patients. The median values of TXB2 were: 360 pg/ml in multiple injured, 250 pg/ml in abdominal surgery and 410 pg/ml in acute pancreatitis patients. The median TXB2 value was 575 pg/ml in patients developing ARDS and 140 pg/ml in those without this complication: this difference was statistically significant (p〈0.05). The median values of 6-keto-PGF1α were 55pg/ml in multiple injured, 25 pg/ml in abdominal surgery and 120 pg/ml in acute pancreatitis patients. The median 6-keto-PGF1α value was 122 pg/ml in ARDS patients and 25 pg/ml in non-ARDS patients (statistically significant: p〈0.05). High TXB2 and 6-keto-PGF1α values were particularly related to sepsis in abdominal surgery patients (p〈0.05) and in multiple injured patients (p〈0.01). No relation could be established between abnormal TXB2 or 6-keto-PGF1α values and death. High TXB2 values often persisted for several days and were observed particularly at the time ARDS diagnostic criteria were fulfilled. An imbalance between TXB2 and 6-keto-PGF1α was observed: 6-keto-PGF1α values were always lower than TXB2 values and did not persist for more than 24 h except in four cases. Our data demonstrate a significant production of prostanoids in ARDS patients particularly in sepsis and indicate a disturbance in balance of the prostacyclin/thromboxane axis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00254700
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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