Electronic Resource
Springer
European journal of clinical microbiology & infectious diseases
2 (1983), S. 340-344
ISSN:
1435-4373
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Eight volunteers each received lg of probenecid followed immediately by 1.5 g sultamicillin, both given by the oral route. Plasma concentrations of ampicillin and sulbactam were measured using a differential bioassay method. An ampicillin mean peak plasma concentration of 23.1 mg/l was found typically 1.5 h after dosing; the mean peak plasma concentration of sulbactam (10.0 mg/l) occurred at the same time. The mean plasma half-life of ampicillin was 1.45 h and that of sulbactam 1.3 h. The mean urinary recovery of ampicillin was 65 % and that of sulbactam 62 %. Five of the volunteers reported minor changes in bowel habits.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02019464
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