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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 93 (1971), S. 4312-4314 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of medicinal chemistry 16 (1973), S. 1245-1251 
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    CNS drug reviews 8 (2002), S. 0 
    ISSN: 1527-3458
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Significant physiologic changes occur during menopause. Evidence exists to suggest that estrogen may be neuroprotective under specific conditions. However, there are limitations in the neuroprotection afforded by standard hormone therapy. Accordingly, alternative agents with selected estrogenic effects may hold even greater promise rather than conventional hormone replacement therapy for the prevention and treatment of CNS injury. Recently, a variety of selective estrogen receptor modulators (SERMs) have been developed to retain the favorable and minimize the adverse side effects of estrogens. This review focuses on the CNS and known neuroprotective effects of two specific SERMs, raloxifene and arzoxifene. Recent studies hint that raloxifene and arzoxifene are neuroprotective and may preserve some elements of cognitive function. However, the mechanism of action is not well described and it is unclear if the beneficial effects of SERMs rely on activation of estrogen receptors.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Archives of environmental contamination and toxicology 37 (1999), S. 496-502 
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract. The acute and chronic toxicity of fluoranthene was determined for a diverse group of freshwater and saltwater species under both standard laboratory fluorescent light and ultraviolet (UV) light test conditions. Acute tests with 21 species demonstrated that fluoranthene was not lethal within its water solubility limit to most species tested under fluorescent light, but was lethal well below this limit to nearly all of the species tested under UV light. In general, the acute sensitivity of freshwater and saltwater species from the same class was similar, although UV light exposure changed the relative sensitivity of some species. Crustaceans were the most sensitive to fluoranthene, but in the presence of UV light, an oligochaete and a fish were the most sensitive. Overall, UV light increased acute fluoranthene toxicity approximately one to three orders of magnitude. In chronic tests, sublethal concentrations of fluoranthene were toxic under both fluorescent and UV light, but as in most acute tests, UV light increased chronic toxicity approximately an order of magnitude. Comparison of data from tests conducted in the laboratory and outdoors demonstrated that acute toxicity increased with increased UV light intensity.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical microbiology & infectious diseases 2 (1983), S. 340-344 
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eight volunteers each received lg of probenecid followed immediately by 1.5 g sultamicillin, both given by the oral route. Plasma concentrations of ampicillin and sulbactam were measured using a differential bioassay method. An ampicillin mean peak plasma concentration of 23.1 mg/l was found typically 1.5 h after dosing; the mean peak plasma concentration of sulbactam (10.0 mg/l) occurred at the same time. The mean plasma half-life of ampicillin was 1.45 h and that of sulbactam 1.3 h. The mean urinary recovery of ampicillin was 65 % and that of sulbactam 62 %. Five of the volunteers reported minor changes in bowel habits.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of applied electrochemistry 12 (1982), S. 205-211 
    ISSN: 1572-8838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Notes: Abstract A mathematical analogue based on an array of transmission lines has been used to predict the performance of chemically modified three-dimensional electrodes under typical conditions. Even for reactions with low exchange currents, considerable non-uniformity of activation is predicted in the direction of current flow so that the electrode cannot be scaled-up indefinitely in this direction without penalty. At the same time the conversion per pass of the electrode is so low that it can be considered to be a constant concentration system. An approximate economic forecast based on the results of the model suggests production costs of the order of $500 to $5000 kg−1 for a product of molecular weight 200, depending on the thickness of the electrode and the maximum permissible overvoltage. Installed capital costs are estimated to total about $ 100000 for a capacity of 20 to 170 kg−1 y−1) also depending on the maximum permissible overvoltage.
    Type of Medium: Electronic Resource
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