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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 90 (1983), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Uteroplacental blood flow index was determined in 30 women with intrauterine growth retardation (IUGR group) and in 26 women without fetal growth retardation (control group) during the last trimester of pregnancy. After 1 mCi (37 MBq) of indium-113m chloride had been injected intravenously the radiation was registered by a computer-linked scintillation camera positioned above the placenta during 10 s-intervals for 240 s. From the isotope accumulation curve a Uteroplacental blood flow index could be calculated for each patient. The median blood flow index in the IUGR group was less than half of that in the control group. In the IUGR group the index was as low in the six women who gave birth to infants with congenital malformations as in the other 24 women in whom fetal growth retardation was due to maternal factors.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 89 (1982), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. The effect of a new antihypertensive drug, labetalol, on uteroplacental blood flow was determined in eight pre-eclamptic women. After injection of 0.5 mCi of 113mIn the radioactivity in the placenta was recorded by a gamma camera linked to a computer and the placental blood-flow index was calculated from the ratio between the maximum radioactivity of the isotope-accumulation curve and the rise time of the curve. Labetalol, a combined α- and β-adrenoceptor antagonist was given intravenously and after 30 min a second uteroplacental blood-flow index was calculated. There was a significant mean decrease of blood pressure from 147/98 to 128/83 mmHg, but no change in uteroplacental blood-flow index, so that uteroplacental vascular resistance tended to decrease.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of medicine & science in sports 2 (1992), S. 0 
    ISSN: 1600-0838
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Sports Science
    Notes: The natural course of 46 stress fractures of the tibia were studied in relation to sports activity, diagnosis and treatment in 28 recreational athletes and 13 elite athletes. Two major types of stress fractures were observed. Thirty athletes sustained a posteriomedial fracture of the tibia and claimed a sudden onset of exertional pain. The initial symptoms occurred during running or orienteering (n= 19), soccer (n= 4), workout or dancing (n= 3), triathlon, basketball, badminton and tennis (one each) and were similarity distributed between left and right leg. Scintigraphs showed Zwas type I/II lesions, while X-rays were negative in most cases. The patients were treated only with restriction in sports activities. The fractures healed within 8–24 weeks with excellent or good results. The remaining 11 athletes had anterior margin stress fractures with a slow onset of exertional pain and a long delay in diagnosis. These injuries occurred in 4 long-distance runners, 2 handball players, 2 dancers, 1 volleyball player, 1 triathloner and 1 decathloner. They were located in the nondominant left leg (in three cases bilateral). The fractures showed Zwas I or II lesions on scintigrams, but differed from the posteriomedial injuries on the typical V-shape appearence on X-ray. The patients had conservative treatment, including immobility and restriction in sports activities. Four of the patients were operated when not symptom-free after 12–34 months. All elite athletes (n= 5) in this group had to interrupt then-elite carreer. At follow up 24–60 months after the initial symptoms, only 1 patient was symptom-free. Thus, posteriomedial tibial stress fractures show a sudden onset and benign natural course, while anterior stress fractures should be treated with caution. The use of bone scintigraphy should be emphasized early when an athlete presents with exertional lower leg pain.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 40 (1978), S. 223-232 
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study was carried out in order to obtain data on the relation between tumour structures seen in computer tomograms and the corresponding histopathology and cytology. Nine consecutive patients were studied, and stereotactic biopsies were obtained from sites determined on contrast enhanced computer tomograms. Biopsies were obtained from tumour areas with high and low contrast uptake and from the low attenuating areas surrounding the tumours. The results indicated a close correlation between the microscopical morphology of gliomas and the pattern of the computer tomogram. Biopsy samples from low-uptake central areas contained tumour tissue, necrotic tissue, and in one case a cyst. Biopsies from high-uptake areas typically contained tumour tissue, whereas biopsies from low-uptake surrounding areas contained oedematous non-tumour tissue. For tumour diagnosis biopsies should be obtained from both low and high attenuating tumour areas.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 17 (1980), S. 437-442 
    ISSN: 1432-1041
    Keywords: indomethacin ; rheumatoid arthritis ; double-blind cross-over study ; placebo ; clinical effect ; technetium uptake ; plasma concentration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Indomethacin 0, 15, 25 and 35 mg t. i. d. was given in randomized order for two weeks to eight outpatients with rheumatoid arthritis in a double-blind study. At the end of each treatment period the clinical response was evaluated by subjective and objective methods and the plasma indomethacin concentration was measured by GLC-mass fragmentography. Compared with non-treatment periods, indomethacin had a statistically significant therapeutic effect as judged by global assessment, duration of morning stiffness, use of escape analgesia, articular index and pain score, but there was no relation between the clinical effect and the size of the dose or the plasma concentration of the drug. Technetium uptake over the affected joints did not change during indomethacin therapy, which might reflect a lack of effect on the local activity of the disease. Lower doses than those currently prescribed are probably sufficient to alleviate symptoms in this disease.
    Type of Medium: Electronic Resource
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