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  • 1
    Electronic Resource
    Electronic Resource
    Blood pressure and renal function seven years after pregnancy complicated by hypertension (1995)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 102 (1995), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To assess the occurrence of chronic hypertension and renal disorder after gestations complicated by pregnancy induced hypertension or pre-eclampsia and to define background factors and laboratory analyses at follow up examination which discriminate between women who remain normotensive and those who develop hypertension.Setting Swedish university hospital.Subjects Women with pregnancy induced hypertension (PIH) (n= 49), pre-eclampsia (n= 45) or a normotensive pregnancy (n= 44) during 1986.Design Subjects were reviewed in 1993 with regard to chronic hypertension and renal disorder. Plasma concentrations of creatinine, urea, uric acid, calcium and albumin were measured, and urine was examined for the presence of microalbuminuria and erythrocyte excretion rate. Those with and without hypertension at follow up were compared with regard to the renal function tests and possible features in the history which might predict chronic hypertension.Results Women with a history of pregnancy induced hypertension or pre-eclampsia had an increased risk, relative to controls, for hypertension at follow up (37% and 20%vs 2%; P 〈 0.001), microalbuminuria (14% and 20%vs 2%; P 〈 0.05) and demonstrated increased plasma levels of albumin corrected calcium (2.41 [SE 0.021 and 2.40 [0.01] vs 2.32 [0.01] mmol/l; P 〈 0.001). The only factors significantly associated with hypertension at follow up were the presence of microalbuminuria (P= 0.0008) and having had a delivery prior to the index pregnancy (P= 0.0017).Conclusions The risk for chronic hypertension seven years after a pregnancy complicated with pregnancy induced hypertension or pre-eclampsia is considerably increased. The presence of hypertension at follow up is closely related to residual renal disorder.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1995.tb10874.x
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  • 2
    Electronic Resource
    Electronic Resource
    Prediction of size of infants at birth by measurement of symphysis fundus height (1986)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 93 (1986), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Symphysis fundus heights (SF) were measured approximately 15 times during pregnancy in a consecutive series of 2941 women with regular menstrual cycles and known last menstrual period. A reference SF chart from 17 to 40 weeks of pregnancy was derived from measurements in 1350 of these women who were healthy, and heights and pre-pregnancy weights within the 10th and 90th centiles and were delivered vaginally of healthy infants with a birthweight/length ratio within ±2SD. The reference chart was used to predict fetal growth deviations in the unselected series of pregnancies. The effectiveness of SF measures to detect fetuses with an infant birthweight/length ratio below −2SD or a birthweight below the 10th centile was low; the sensitivity was only 16·7 and 26·6% and the predictive value of positive screening result was 1·8 and 18·0%, respectively. Corresponding values for fetuses with an infant birthweight/length ratio above +2 SD or a birthweight above the 90th centile were 31·8 and 37·5% and 3·3 and 24·5%, respectively. Symphysis fundus (SF) measurement has thus been found to be of limited value as a screening method to detect abnormal size at birth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1986.tb07894.x
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  • 3
    Electronic Resource
    Electronic Resource
    Uteroplacental blood flow index in intrauterine growth retardation of fetal or maternal origin (1983)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 90 (1983), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Uteroplacental blood flow index was determined in 30 women with intrauterine growth retardation (IUGR group) and in 26 women without fetal growth retardation (control group) during the last trimester of pregnancy. After 1 mCi (37 MBq) of indium-113m chloride had been injected intravenously the radiation was registered by a computer-linked scintillation camera positioned above the placenta during 10 s-intervals for 240 s. From the isotope accumulation curve a Uteroplacental blood flow index could be calculated for each patient. The median blood flow index in the IUGR group was less than half of that in the control group. In the IUGR group the index was as low in the six women who gave birth to infants with congenital malformations as in the other 24 women in whom fetal growth retardation was due to maternal factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1983.tb06739.x
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  • 4
    Electronic Resource
    Electronic Resource
    Fetal plasma catecholamine concentrations and fetal heart-rate variability during first stage of labour (1983)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 90 (1983), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Fetal heart-rate (FHR) variability was studied in 50 term fetuses during the first stage of labour. The variability was computed as an arbitrary index during a 20-min period preceding a fetal scalp blood sample which was used for the measurement of pH, adrenaline and noradrenaline. None of the fetuses was found to have a scalp blood pH〈7.2. The short-term variability index was significantly correlated with the noradrenaline concentration in fetal blood, but the adrenaline levels which were generally very low showed no correlation with the variability values. There was no correlation between variability index and cervical dilatation or blood pH. We have shown previously high plasma catecholamine concentrations in the asphyxiated fetus with a decreased pH. In this study where fetal pH was normal a correlation between FHR variability and fetal scalp plasma noradrenaline levels was found. Thus an increased FHR variability might be an early sign of fetal distress when fetal pH is still normal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1983.tb06738.x
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  • 5
    Electronic Resource
    Electronic Resource
    TOTAL AND FREE CORTISOL IN AMNIOTIC FLUID DURING LATE PREGNANCY (1978)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 85 (1978), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Total cortisol levels were measured in 81 samples of amniotic fluid obtained from 72 patients in the third trimester of pregnancy; 19 of them had pre-eclampsia and the remainder had no pre-eclampsia, hypertension or renal disease. In accordance with previous studies, there was a rise in the concentration of amniotic fluid cortisol with advancing gestation; the rise was steepest after 40 weeks, the amniotic fluid cortisol levels invariably being above 700 nmoI/I between 41 and 43 weeks of pregnancy. Amniotic fluid cortisol may thus be of value in diagnosing postmaturity. A relatively low correlation was found between total cortisol levels and lecithin/sphingomyelin ratios in amniotic fluid unless results were ranked for gestational age. Total cortisol concentrations in amniotic fluid obtained from patients with pre-eclampsia were significantly higher than in controls. The concentration of free cortisol in amniotic fluid changed much less than total cortisol. Thus total cortisol should be measured in studies of the fetal capacity to synthesize corticosteroids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1978.tb14912.x
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  • 6
    Electronic Resource
    Electronic Resource
    Acute effect of an antihypertensive drug, labetalol, on uteroplacental blood flow (1982)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 89 (1982), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. The effect of a new antihypertensive drug, labetalol, on uteroplacental blood flow was determined in eight pre-eclamptic women. After injection of 0.5 mCi of 113mIn the radioactivity in the placenta was recorded by a gamma camera linked to a computer and the placental blood-flow index was calculated from the ratio between the maximum radioactivity of the isotope-accumulation curve and the rise time of the curve. Labetalol, a combined α- and β-adrenoceptor antagonist was given intravenously and after 30 min a second uteroplacental blood-flow index was calculated. There was a significant mean decrease of blood pressure from 147/98 to 128/83 mmHg, but no change in uteroplacental blood-flow index, so that uteroplacental vascular resistance tended to decrease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1982.tb04719.x
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  • 7
    Electronic Resource
    Electronic Resource
    METABOLIC AND CIRCULATORY EFFECTS OF ORAL SALBUTAMOL IN THE THIRD TRIMESTER OF PREGNANCY IN DIABETIC AND NON-DIABETIC WOMEN (1981)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 88 (1981), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Metabolic and cardiovascular effects of 4 mg oral salbutamol were studied in ten non-diabetic, ten chemical diabetic and five juvenile diabetic women in late pregnancy. None of the women had been treated with beta-sympathomimetic drugs earlier in their pregnancy. Heart rate and blood pressure were recorded and blood samples for measurement of plasma cyclic AMP, insulin, C-peptide, glucose, lactate, glycerol, non-esterified fatty acids (NEFA) and 3-hydroxybutyrate (3-HB) were collected every 30 minutes for 120 minutes after salbutamol. All women underwent the same procedure at random without salbutamol. There were significant cardiovascular effects of salbutamol in all the groups but no differences in these effects between the groups. Salbutamol caused significant increases of glycogenolysis and lipolysis in all the groups, significantly larger in the juvenile diabetic than the non-diabetic and chemical diabetic women. This observation could be explained by the inability of the juvenile diabetics to secrete insulin, shown by their non-measurable plasma C-peptide levels. The metabolic responses following salbutamol in the chemical diabetics were intermediate between the non-diabetic and juvenile diabetic groups. The results show that diabetes does not alter the sensitivity of beta-receptors involved in cardiovascular regulation, while the metabolic responses to oral salbutamol are enhanced, especially in juvenile diabetics. We suggest that during treatment with beta-sympathomimetic drugs, blood glucose should be monitored in all patients showing criteria of potential diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1981.tb00996.x
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  • 8
    Electronic Resource
    Electronic Resource
    Arachidonic acid in amniotic fluid after extra-amniotic instillation of rivanol for midtrimester abortion
    Amsterdam : Elsevier
    Prostaglandins 16 (1978), S. 989-994 
    Details
    ISSN: 0090-6980
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0090-6980(78)90116-8
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  • 9
    Electronic Resource
    Electronic Resource
    Actions of salbutamol in late pregnancy: Plasma cyclic AMP, insulin and C-peptide, carbohydrate and lipid metabolites in diabetic and non-diabetic women (1978)
    Springer
    Diabetologia 14 (1978), S. 235-242 
    Details
    ISSN: 1432-0428
    Keywords: Cyclic AMP ; insulin β2-adrenergic agonists ; diabetes ; pregnancy and metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Salbutamol was administered intravenously in doses increasing from 3.75 to 22.5 μg/min to 5 non-diabetic and 7 diabetic women in the last trimester of pregnancy. In diabetic as well as nondiabetic women the diastolic blood pressure fell progressively with increasing doses, and the systolic BP and heart rate increased at doses above 7.5 μg/min. The effect on fetal heart rate was less pronounced than the effect on maternal heart rate. Cyclic AMP levels in plasma were similar in non-diabetic and diabetic women before salbutamol. Twenty min following 3.75 μg/min a significant increase was seen in both groups. The peak increase (3–5 fold) was higher in the diabetic than in the non-diabetic women. Plasma insulin and C-peptide levels rose in a dose-dependent manner in the non-diabetic and four of the diabetic women. However, in three of the diabetic women the insulin level was unaffected by salbutamol and C-peptide was almost undetectable. Plasma concentrations of glucose, glycerol, NEFA and 3-HB were higher in the diabetics than in the non-diabetics before salbutamol and the elevations induced by salbutamol were also significantly larger in the diabetic women. The present data show that salbutamol in doses employed clinically may cause pronounced metabolic effects, especially in diabetic women, and it is suggested that when intravenous infusion of salbutamol is given to pregnant diabetic women not only cardiovascular but also some metabolic variable such as glucose should be carefully monitored.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01219422
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  • 10
    Electronic Resource
    Electronic Resource
    Further simplification of a supernatant flow system for tissue culture (1961)
    Springer
    Cellular and molecular life sciences 17 (1961), S. 94-95 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung In der Arbeit wird eine Einrichtung für kontinuierliche Flüssigkeitszufuhr beschrieben, wie sie für Gewebskulturen wertvoll sein kann. Durch eine feinporöse Membran kann die Menge der Flüssigkeit reguliert werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02171448
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