ISSN:
1432-2013
Keywords:
Clearance of PAH
;
Na+ reabsorption
;
Protein/DNA ratio
;
RNA/DNA ratio
;
Time response
;
Triiodothyronine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Experiments were carried out to compare temporal changes in the paraaminohippuric acid clearance (C PAH), renal sodium reabsorption ( $$R_{Na^ + } $$ ), ribonucleic acid (RNA), and deoxyribonucleic acid (DNA) content in hypothyroid rats after a single injection of triiodothyronine (T3) (50 μg/100 g body wt).C PAH and $$R_{Na^ + } $$ showed no changes at 24 and 48 h. At 72 h, however, significant increases of 41% and 42% (per g kidney wet wt) were observed inC PAH and $$R_{Na^ + } $$ , respectively. The cortex in T3-treated hypothyroid rats showed a significant increase in the protein/DNA and RNA/DNA ratios at 24 h and progressive increases to a level of 24%, and 37%, respectively, at 48 h. No changes in DNA content were observed at either time-points. The results show that the increases in RNA/DNA and protein/DNA ratios upon T3 treatment preceded the increases inC PAH and $$R_{Na^ + } $$ , suggesting a direct effect of T3 on renal cortical growth, rather than a secondary response to a primary increase in renal functions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00590205
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