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  • 1
    ISSN: 1432-2013
    Keywords: Triiodothyronine ; NaK-ATPase ; Submandibular gland ; Parotid gland ; Sublingual gland
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The present studies concern the effect of triiodothyronine (T3) on rat salivary (Na++K+)-adenosine triphosphatase (NaK-ATPase). The results indicate that T3 selectively increased submandibular and parotid NaK-ATPase units with a single, large dose of T3, different dosage of T3, three successive doses of T3 given on alternate days, and “physiological” doses of T3 with daily injection for 2 weeks. Sublingual NaK-ATPase was insensitive to T3 in the above experiments. The effect of T3 on submandibular and parotid NaK-ATPase is selective since Mg-ATPase and 5′-nucleotidase showed no significant differences under different thyroid status. The lack of response of NaK-ATPase to reverse T3, further substantiates the specificity of T3 on salivary NaK-ATPase.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2013
    Keywords: Corticosterone ; Dexamethasone ; Triiodothyronine ; Thyroidadrenalectomy ; Adrenalectomy ; NaK-ATPase activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The present study concerns the effect of glucocorticoids and triiodothyronine (T3) on rat salivary (Na++K+)-adenosine triphosphatase (NaK-ATPase). The results indicate that corticosterone increases submandibular gland NaK-ATPase activity with a single dose of hormone and with two daily doses on three successive days. Multiple injections of dexamethasone also increases submandibular and sublingual gland NaK-ATPase activity. The effect of glucocorticoids on salivary NaK-ATPase is selective since Mg-ATPase shows no significant differences under different steroidal states. We subsequently investigate the possibility of interaction between the effects of corticosterone and triiodothyronine on submandibular gland NaK-ATPase activity. Our studies indicate that each of these hormones increases NaK-ATPase activity in the absence of the other.
    Type of Medium: Electronic Resource
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