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  • 1
    Electronic Resource
    Electronic Resource
    GENOMIC IMPRINTING IN MAMMALS (1997)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Genetics 31 (1997), S. 493-525 
    Details
    ISSN: 0066-4197
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Notes: Abstract A handful of autosomal genes in the mammalian genome are inherited in a silent state from one of the two parents, and in a fully active form from the other, thereby rendering the organism functionally hemizygous for imprinted genes. To date 19 imprinted genes have been identified; 5 are expressed from the maternal chromosome while the rest are expressed from the paternal chromosome. Allele-specific methylation of CpG residues, established in one of the germlines and maintained throughout embryogenesis, has been clearly implicated in the maintenance of imprinting in somatic cells. Although the function of imprinting remains a subject of some debate, the process is thought to have an important role in regulating the rate of fetal growth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.genet.31.1.493
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Parental imprinting of the mouse H19 gene (1991)
    [s.l.] : Nature Publishing Group
    Nature 351 (1991), S. 153-155 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] To determine whether a gene is imprinted, one must be able to distinguish expression from the maternal and paternal alleles. We used an RNase protection assay that is very sensitive to base substitutions and discontinuities in RNA sequences6. Hybrid Fl mice generated from an interspecies cross ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/351153a0
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  • 3
    Electronic Resource
    Electronic Resource
    A paternal–specific methylation imprint marks the alleles of the mouse H19 gene (1995)
    [s.l.] : Nature Publishing Group
    Nature genetics 9 (1995), S. 407-413 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Imprinting, the differential expression of the two alleles of a gene based on their parental origin, requires that the alleles be distinguished or marked. A candidate for the differentiating mark is DNA methylation. The maternally expressed H19 gene is hypermethylated on the inactive paternal ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng0495-407
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  • 4
    Electronic Resource
    Electronic Resource
    Strategies for dissecting epigenetic mechanisms in the mouse (2005)
    [s.l.] : Nature Publishing Group
    Nature genetics 37 (2005), S. 1194-1200 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Epigenetics generally refers to heritable changes in gene expression that are independent of nucleotide sequence. With complete genome sequences in hand, understanding the epigenetic control of genomes is the next step towards comprehending how the same DNA sequence gives rise to different cells, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1664
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  • 5
    Electronic Resource
    Electronic Resource
    Physical linkage of two mammalian imprinted genes, H19 and insulin–like growth factor 2 (1992)
    [s.l.] : Nature Publishing Group
    Nature genetics 2 (1992), S. 61-65 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Parental imprinting is a phenomenon in mammals whereby the maternal and paternal alleles of a gene are differentially expressed. Three murine genes have been shown to display this type of allele–specific expression. Two of them, insulin–like growth factor–2 (Igf–2) and H19, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng0992-61
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  • 6
    Electronic Resource
    Electronic Resource
    Maintaining imprinting (2000)
    [s.l.] : Nature America Inc.
    Nature genetics 25 (2000), S. 4-5 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The mechanism of genomic imprinting, which affects a subset of genes in the mammalian genome and results in parent-of-origin–specific gene-expression patterns, is poorly understood. The dissection of certain human genetic diseases caused by disruption of imprinted gene ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/75575
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  • 7
    Electronic Resource
    Electronic Resource
    The search for imprinted genes (1994)
    [s.l.] : Nature Publishing Group
    Nature genetics 6 (1994), S. 220-221 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Parental imprinting, or the differential expression of the maternal and paternal alleles of a gene, has received a great deal of attention in the past few years. The phenomenon, which renders mammals functionally hemizygous for an unknown number of genes, seems to be evolutionarily unsound. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng0394-220
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  • 8
    Electronic Resource
    Electronic Resource
    Antagonism between DNA hypermethylation and enhancer-blocking activity at the H19 DMD is uncovered by CpG mutations (2004)
    [s.l.] : Nature Publishing Group
    Nature genetics 36 (2004), S. 883-888 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Imprinted expression at the H19-Igf2 locus depends on a differentially methylated domain (DMD) that acts both as a maternal-specific, methylation-sensitive insulator and as a paternal-specific site of hypermethylation. Four repeats in the DMD bind CCCTC-binding factor (CTCF) on the maternal allele ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1399
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of corticosterone and triiodothyronine on (Na++K+)-adenosine triphosphatase activity in rat submandibular gland (1983)
    Springer
    Pflügers Archiv 399 (1983), S. 255-258 
    Details
    ISSN: 1432-2013
    Keywords: Corticosterone ; Dexamethasone ; Triiodothyronine ; Thyroidadrenalectomy ; Adrenalectomy ; NaK-ATPase activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The present study concerns the effect of glucocorticoids and triiodothyronine (T3) on rat salivary (Na++K+)-adenosine triphosphatase (NaK-ATPase). The results indicate that corticosterone increases submandibular gland NaK-ATPase activity with a single dose of hormone and with two daily doses on three successive days. Multiple injections of dexamethasone also increases submandibular and sublingual gland NaK-ATPase activity. The effect of glucocorticoids on salivary NaK-ATPase is selective since Mg-ATPase shows no significant differences under different steroidal states. We subsequently investigate the possibility of interaction between the effects of corticosterone and triiodothyronine on submandibular gland NaK-ATPase activity. Our studies indicate that each of these hormones increases NaK-ATPase activity in the absence of the other.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00652748
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  • 10
    Electronic Resource
    Electronic Resource
    Clustered α-amanitin resistance mutations in mouse (1995)
    Springer
    Molecular genetics and genomics 246 (1995), S. 778-782 
    Details
    ISSN: 1617-4623
    Keywords: RNA polymerase II ; α-Amanitin Mutation ; Transcription
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We report the identification of three new α-amanitin resistance mutations in the gene encoding the largest subunit of mouse RNA polymerase II (RPII215). These mutations are clustered in a region of the largest subunit that is important for transcription elongation. This same domain has been identified as the site of α-amanitin resistance mutations in both Drosophila and Caenarhabditis elegans. The sequences encompassing this cluster of mutations are highly conserved among RNA polymerase II genes from a number of species, including those that are naturally more resistant to α-amanitin suggesting that this region of the largest subunit is critical for a conserved catalytic function. The mutations reported here change leucine 745 to phenylalanine, arginine 749 to proline, or isoleucine 779 to phenylalanine. Together with the previously reported asparagine 792 to aspartate substitution these mutations define a potential α-amanitin binding pocket in a region of the mouse subunit that could be involved in translocation of polymerase during elongation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00290727
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