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  • 1
    Electronic Resource
    Electronic Resource
    Electroinduction of interferon-like proteins
    Amsterdam : Elsevier
    Journal of Electroanalytical Chemistry 320 (1991), S. 183-193 
    Details
    ISSN: 0022-0728
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-0728(91)85626-Z
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  • 2
    Electronic Resource
    Electronic Resource
    Electroinduction of interferon-like proteins
    Amsterdam : Elsevier
    Bioelectrochemistry and Bioenergetics 25 (1991), S. 183-193 
    Details
    ISSN: 0302-4598
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0302-4598(91)87002-X
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  • 3
    Electronic Resource
    Electronic Resource
    Polycationic modified polypeptides enhancing poly I:C induced viral resistance (1975)
    Springer
    Cellular and molecular life sciences 31 (1975), S. 1165-1166 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Polycationic modified derivatives of polyglutamic acid are at least as good enhancers of poly I:C induced viral resistance in various cell cultures as are DEAE-dextran or poly-l-lysine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02326771
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  • 4
    Electronic Resource
    Electronic Resource
    Inhibition of local calcergy by topical application of calciphylactic challengers (1968)
    Springer
    Calcified tissue international 2 (1968), S. 67-76 
    Details
    ISSN: 1432-0827
    Keywords: Calcergy ; Calciphylaxis ; Calcium ; Metals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Description / Table of Contents: Résumé Chez le rat, des expériences ont montré que, sauf de rares exceptions, les calcifications produites au site d'injection d'acétate de plomb, de chlorure de cérium, chlorure de calcium ou de permanganate de potassium sont complètement prévenues ou fortement inhibées par l'application locale simultanée de provocateurs calciphylactiques, mais non par des agents non provocateurs. Malgré quelques exceptions (attribuées à des interrelations chimiques spécifiques entre certaines des substances utilisées), cette curieuse corrélation entre l'efficacité calciphylactique provocatrice et le pouvoir anticalcergique est, d'après le test χ2, hautement significative (P〈0,001).
    Abstract: Zusammenfassung Nach subcutaner Injektion von Bleiacetat, Ceriumchlorid, Calciumchlorid oder Kaliumpermanganat tritt an der Injektionsstelle eine starke Verkalkung auf. Bis auf sehr wenige Ausnahmen kann diese durch gleichzeitige lokale Anwendung von calciphylaktischen Provokatoren verhütet oder weitgehend unterdrückt werden. In dieser Beziehung sind nicht provolatorisch wirkende Stoffe inaktiv. Trotz der wenigen Ausnahmen (die wahrscheinlich auf spezifische, chemische Wechselwirkungen zwischen manchen der untersuchten Substanzen beruhen) ist dieser merkwürdige Zusammenhang zwischen calciphylaktisch provozierender und anticalcergischer Aktivität, nach dem χ2-Test berechnet, statistisch hochsignifikant (P〈0,001).
    Notes: Abstract Experiments on rats indicate that, with very few exceptions, the calcification which occurs at subcutaneous sites of treatment with lead acetate, cerium chloride, calcium chloride or potassium permanganate is completely blocked or severely inhibited by simultaneous topical application of calciphylactic challengers but not of non-challengers. Despite the few exceptions (which are thought to depend upon specific chemical interactions between some of the compounds tested) this singular correlation between calciphylactic challenging and anticalcergic potency, is highly significant by the Chi-square-test (P〈0.001).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02279195
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  • 5
    Electronic Resource
    Electronic Resource
    Direct evidence for the anti-inflammatory effect of human interferon-α in CFLP mice (1985)
    Springer
    Archives of virology 85 (1985), S. 151-155 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In CFLP mice, intravenously administered partially purified interferon-α (IFN-α 2×106 µ/mg protein), prepared from human leukocytes, reduced carrageenan-induced paw swelling and produced slight irritation when injected into the footpad. Anti-human IFN-α serum abolished the anti-inflammatory effect but did not influence local phlogogenic activity. Highly purified human IFN-α (1.2×108 µ/mg protein) was also found to be anti-inflammatory after intravenous administration, and devoid of irritative effect at the injection site. These results suggest that human IFN-α possesses a direct inhibitory effect on acute inflammation in mice, and the irritation appearing at the site of its application might be due to some impurities being present in the partially purified preparations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01317015
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  • 6
    Electronic Resource
    Electronic Resource
    On the anti-inflammatory effect of sendai virus inoculation (1981)
    Springer
    Archives of virology 67 (1981), S. 91-95 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sendai virus given intravenously into CFLP mice produced dose-related suppression of the acute inflammation produced by carrageenan and 5-HT. The inhibition correlated with interferon levels in the blood, suggesting that interferon may account for the virus-induced anti-inflammatory effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01314606
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  • 7
    Electronic Resource
    Electronic Resource
    Purification of human leukocyte interferon alpha by Carboxymethyl Controlled Pore Glass bead chromatography (1984)
    Springer
    Archives of virology 81 (1984), S. 303-311 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Human leukocyte-derived alpha interferon [HuIFN-α(Le)] has been purified and/or concentrated on Carboxymethyl derivatized Controlled Pore Glass (CML-CPG240) beads. These glass beads adsorb HuIFN-α(Le) efficiently at acid pH and at physiological ionic strengths. Elution of HuIFN-α(Le) may be accomplished by several methods. Using buffers at relatively high ionic strengths (approximately 0.6 M) and pH values ranging from 2.6 to 6.9 for elution, preparations with specific activities of 105–106 IU/mg were obtained with approximately 90 percent recoveries. Alternatively, using elution buffers at the same high ionic strength and at pH values ranging from 7.0 to 8.0, five-fold or better concentration and complete recovery of crude HuIFN-α(Le) were achieved. The resulting preparations were suitable for direct application to an antibody affinity chromatography column.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01310000
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  • 8
    Electronic Resource
    Electronic Resource
    Potentiation of poly I: C induced viral resistance by polycationic modified polypeptides (1976)
    Springer
    Archives of virology 51 (1976), S. 227-234 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The potentiation of polyI:C induced viral resistance by various side group modified polycationic polyglutamic acid derivatives was investigated. It was established that the efficacy of the various polycationic substances depends primarily on their macromolecular properties. Viscosity and the degree of cationic substitution have been found to be of paramount importance. The maximal potentiating efficacy, expressed as the minimum protective dose of polyI:C necessary for complete protection of cells in the presence of the polycations, was exerted by compounds of highest viscosity and degree of substitution. The potentiating efficacy of the polycationic derivatives tested could only be observed in a relatively narrow range of concentration, depending on their viscosity and degree of substitution. In view of the extremely low minimal protective dose of polyI:C (10−5 µg/ml) in the presence of our most effective compound it is assumed that the action of a few molecules of polyI:C may be sufficient to render a cell resistant against viral infection. Within the limits of the described experiments, the efficacy of polycationic derivatives did not seem to be influenced by the modification (e.g. quaternarization) of the cationic group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01318026
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  • 9
    Electronic Resource
    Electronic Resource
    Protection by steroids against acute HgCl2 poisoning (1970)
    Springer
    International urology and nephrology 2 (1970), S. 287-301 
    Details
    ISSN: 1573-2584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Experiments on rats indicate that the fatal renal damage normally produced by acute HgCl2 intoxication is more effectively prevented by thioacetyl containing steroids (e.g., spironolactone, spiroxasone or emdabol) than by inorganic sodium thioacetate. Steroids possesing sulfur in forms other than thioacetyl, as well as steroids devoid of sulfur, did not protect against acute HgCl2 intoxication under our experimental conditions. Among a large series of organic and inorganic sulfur compounds, only dimercaprol (BAL) and Na-thioacetate exhibited any noteworthy antimercurial effect in acute tests. However, dimercaprol possesses considerable inherent toxicity whereas sodium thioacetate, though well tolerated in itself, frequently causes sudden death when given in combination with mercury. In view of these findings the thioacetylated steroids appear to represent a promising class of mercury antidotes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02081855
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