ISSN:
1432-072X
Keywords:
Fungal chitin synthetase
;
Inhibitors of chitin synthetase
;
Nikkomycin Z
;
Nikkomycin X
;
Polyoxin A
;
K i values
;
MIC values
;
Mucor rouxii
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract The effect of the nucleoside-peptide antibiotics nikkomycin Z, nikkomycin X, and polyoxin A was tested on chitosomal chitin synthetase from yeast cells of the dimorphic fungus Mucor rouxii. The K i was 0.6 μM for polyoxin A and 0.5 μM for nikkomycin X; nikkomycin Z was slightly less inhibitory (K i=3.5μM). Whereas the minimum inhibitory concentrations of the nikkomycins for growth and germination were quite low (about 1μM, or lower), polyoxin A displayed no antifungal activity against yeast cells and sporangiospores of the test organism, even when present in high concentrations. These results are discussed with respect to structure/activity relationships.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00459518
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