ISSN:
1432-1238
Keywords:
Head injury
;
Free radical
;
Lipoperoxidation
;
Cerebral metabolism
;
Arterio-venous oxygen difference
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Ten severely head injured patients (GCS≤8), aged 17–62 years, were studied in order to investigate the role of lipoperoxidation in secondary brain damage. No patients had intracranial mass lesions, shock, hypoxemia, fever or sepsis. Blood samples were taken from the jugular bulb and from the right atrium, and thiobarbituric acid reacting substances (TBARS) were measured in plasma by spectrophotometry. Arterio-jugular venous oxygen differences (AVDO2) were obtained in seven patients, in order to estimate cerebral blood flow. Jugular TBARS (TBARSj) were always elevated (from To, to 2 h after injury) and correlated in a linear fashion with TBARS of right atrium (TBARSv):r=0.74,p〈0.001. TBARSj and AVDO2 are closely correlated, in accordance with an exponential function (R=0.45,p〈0.001) which describes how any cerebral perfusion derangement determines high levels of TBARSj, confirming lipoperoxidation as a key factor in the final common pathway of secondary posttraumatic brain damage.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01711223
Permalink